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Dorsal agenesis of the pancreas is a rare congenital disorder. We report a case of a 65-year-old man with mild abdominal pain and insulin-dependent diabetes mellitus. Computed tomography (CT) of the abdomen showed a short pancreas with no pancreatic tissue ventral to the splenic vein. Magnetic resonance cholangiopancreatography (MRCP) visualized the absence of a dorsal duct system and confirmed th

Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g., cancer and inflammatory diseases. Aim: To investigate new mechanisms for the regulation of pathological IL-6 production. Methods: PBMCs (peripheral blood mononuclear cells) stimulated by cancer serum factors or specific peptides produce interleukin-6 (IL-6). Immunoregulatory albumin neo-structures and peptides wer

Background: Coronavirus disease 2019 (COVID-19) pandemic constituted the largest global health crisis in recent generations. It may also have disrupted the pattern of antimicrobial use (AMU) and subsequently affected the development of antimicrobial resistance (AMR) – a grave human health concern. This study aimed to give an overview of existing AMR surveillance systems and evaluate the impact of

Introduction: Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cancer immunity. The ambiguous morphological definition of TLS makes it challenging to ascertain their clinical impact on patient survival and response to immunotherapy. Objectives: This study aimed to characterize TLS in hematoxylin-eosin tissue sections from lung can

Two cast Mg–Al–Ba–Ca alloys, DieMag633 and DieMag844, are the focus of this study. Their microstructureMicrostructure consists of a eutectic Ca-rich structure, the lamellar Al2Ca, and of a hard, compact and brittle interdendritic Ba-rich phase, the Mg21Al3Ba2 phase. Both phases have a much higher hardness than the α-Mg matrix and strongly influence the crack propagationCrack propagation under quas

The concept of the rule of law has been a central issue in China for the past two decades, gaining even greater prominence under Xi Jinping’s leadership. This article examines the development of the rule of law in China, drawing on insights from local Chinese scholarship as a vital source for understanding the situation. By analyzing the most cited research articles in the China National Knowledge

Currently, water insecurity is the most common way through which the majority of the global population is experiencing climate change. Projections show that climate change-induced water disasters- floods and droughts chiefly- are expected to increase in the next decades. These circumstances are and will be creating major challenges for peoples’ health and well-being. In this chapter, we present th

"The Value of Knowledge - Towards a Virtue Epistemological Position" The classical question, first posed in Plato's Meno, concerning the value of knowledge constitutes the starting point of this essay. Value analysis has long been neglected in epistemologist's accounts until its re-emergence with the tradition called ?virtue epistemology?, in particular with scholars following Er

This study examines Turkey’s agricultural sector and how it will be affected by a EU membership. Since Turkey has a great rural population and is relatively dependent on its agriculture, the implementation of the CAP will most probably affect not only the rural community, but also the specialization patterns in agriculture and the trade. The aim of this study is to estimate these changes and draw

In the eighteenth century, the portrait genre, previously restricted to royalty and nobility, became available to users from a broader social spectrum. All over Europe, physicians, scholars, writers, merchants, and proprietors had their portraits painted to mark their standing in society. However, not these grand paintings but their printed versions made the sitters known to the broader public. Bu

Occupational therapists support and enable people to partake in occupations or activities that are important to them; that they need/want/are expected to do. Occupational therapists are increasingly involved in services addressing the impact that social inequalities can have on peoples’ wellbeing. One way in which occupational therapy students in NUI Galway learn relevant skills is through service

The enactment of the revised Payment Services Directive (PSD2) by the European Union, has pushed banks to develop digital open banking platforms to enhance market competition and promote innovation in the banking industry. PSD2 mandates banks to offer APIs to provide access to banking data to external third-party providers (TPPs). This mandate might disrupt the role of banks since external complem

Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat analyses. It has been argued that exclusion of patients with OSA with excessive daytime sleepiness (EDS), who may be most likely to benefit from CPAP treatment, may be a

We recently reported that female patients with hypopituitarism receiving controlled thyroid and steroid hormone substitution, but without GH replacement, had a more than 2-fold increase in cardiovascular mortality compared to the general population. In the present study we investigated the incidence of cardiovascular disease as well as the prevalence of cardiovascular risk factors in 33 females wi

We consider the problem of sharing sensitive files across users while relying on a common, untrusted third-party, e.g., a Cloud Storage Provider (CSP). Although users can rely on a secure peer-to-peer (P2P) channel for file sharing, this introduces potential delay on the data transfer and requires the sender to remain connected while the transfer process occurs. Instead, users can upload informati

This paper analyzes the problem and requirements of securely distributing software updates over the Internet,to devices in an Industrial Control System (ICS) and more generally in Internet of Things (IoT) infrastructurescontrolling a physical system, such as power grids and water supply systems. We present a novel approachthat allows to securely distribute software updates of different types, e.g.