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BACKGROUND Linomide, Figure 1, produces robust and consistent in vivo growth inhibition of prostate cancer models via its anti-angiogenic activity and inhibition of autoimmune encephalomyelitis models of multiple sclerosis (MS). MS clinical trials were discontinued because of unacceptable toxicity, due to dose-dependent induction of proinflammation. METHODS Therefore, linomide analogs were initia

Murine gammadelta T cells participate in innate immune response against infection of the intracellular bacterium Listeria monocytogenes. In the present report, we analyzed the mechanism of the gammadelta T cell-mediated response against L. monocytogenes infection. gammadelta T cell-enriched spleen cells of L. monocytogenes-infected mice produced IFN-gamma in vitro in response to L. monocytogenes-i

Flt3 has emerged as a potential regulator of hematopoietic stem cells (HSC). Sixty percent of cells in the mouse marrow Lin(-)Sca1(+)c-kit(+) HSC pool expressed flt3. Although single cell cloning showed comparable high proliferative, myeloid, B, and T cell potentials of Lin(-)Sca1(+)c-kit(+)flt3(+) and Lin(-)Sca1(+)c-kit(+)flt3(-) cells, only Lin(-)Sca1(+)c-kit(+)flt3(-) cells supported sustained

Allergic rhinitis is a common disease characterized by the symptoms of pruritus, sneezing, hypersecretion and nasal blockage. Increased mucosal barrier permeability has been suggested to be an indicator for the severity of allergic rhinitis. This study investigates the passage of radiolabelled albumin from the nasal mucosal circulation into the lumen in guinea pigs intraperitoneally sensitized and

We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human alpha -synuclein in the substantia nigra of adult marmosets. The alpha -synuclein protein was expressed in 90-95% of all nigral dopamine neurons and distributed by anterograde transport throughout their axonal and dendritic projections. The transduced neurons developed severe neuronal pathology, inc

Selected reaction monitoring (SRM) is a mass spectrometry method with documented ability to quantify proteins accurately and reproducibly using labeled reference peptides. However, the use of labeled reference peptides becomes impractical if large numbers of peptides are targeted and when high flexibility is desired when selecting peptides. We have developed a label-free quantitative SRM workflow

The aim of this article is to contribute to literature with new findings from biogenetics that are becoming increasingly important. In particular, we will discuss the new analytic frameworks that may open as a result of the incorporation of epigenetics in evolutionary economic thinking. This new approach is illustrated by studying the evolution of big Internet industry groups such as Apple, Google

På 1970-talet stämde en grupp samer den svenska staten då de ansåg sig ha bättre rätt till ett geografiskt område kallat Skattefjällen. Samer är av svenska staten erkända som ett ursprungsfolk, och som en minoritetsgrupp. Skattefjällsmålet togs upp av Högsta domstolen 1981 och resulterade i ett prejudikat som sedan dess haft stort inflytande på de flesta mål som berört samers rättigheter. Syftet In the 1970s a group of Sami people sued the Swedish State claiming a better right to a geographic area referred to as the Taxed Mountain (Skattefjällen). The Sami people are recognised as an indigenous people, and a minority group, by the Swedish State. The Taxed Mountain Case (Skattefjällsmålet), that reached the Supreme Court (Högsta domstolen) in the year of 1981, resulted in a precedent that

Solens påverkan på klimatet är ett hett ämne i dagens klimatdebatt och utgör en av de största osäkerheterna i vår kunskap om klimatsystemet. Det finns flera sätt som förändringar i solaktivitet skulle kunna påverka klimatet på. En av de föreslagna länkarna mellan solaktivitet och klimat är att den galaktiska kosmiska strålningen (GCR) påverkar bildningen av låga moln. På grund av att låga moln harThe solar influence on climate is a hot topic in today’s climate debate and constitutes one of the largest uncertainties in our knowledge about the climate system. There are several ways in which solar activity changes could affect climate. One of the suggested links between solar activity and climate is an influence from galactic cosmic rays (GCR) on the formation of low clouds. Because of the ne

Syftet med denna studie är att undersöka fyra nutida pianopedagogers syn på hur Frédéric Chopins pianometodik har utvecklats från kompositörens tid fram till nutid. Litteraturen som används för denna studie fokuserar på Chopins tankar om undervisning, Chopin-spel under olika tider, samt traditionsöverföring. Studien baseras på personliga intervjuer och en kvalitativ metod. Data samlas in genom intTitle: "Clever, but not Chopinesque" - A study of four contemporary piano pedagogues’views on Frédéric Chopin’s piano method through the years The purpose of this study is to investigate four contemporary piano pedagogues’ views on how Frédéric Chopin’s pedagogical piano method has developed from the time of the composer to the present day. The literature used for this study focused on C

This essay is going to bring up the terms of adaptation, mainly from book to film and the genre of vampire movies. With the book Låt den rätte komma in and the movie with the same name, I have made an analyzes based on founding out why Tomas Alfredson, the director of the movie cut out some important details from the book while making the movies script together with John Ajvide Lindquist, the auth

The purpose of the study is to investigate the growing trend in consumers to go back to basic lifestyle and to reveal how different events, meanings, experiences and ideas have a role to play in this change in consumers’ attitude. The paper aims to understand this new rising trend and consumer interest and provide a theoretical explanation of the phenomenon. The study focuses on barefoot / minimal

Denna utredning granskar hur proportionalitetsprincipen används i ett förarbete som föreslår straffskärpningar. Syftet är att problematisera huruvida proportionalitetsprincipen kan tillförsäkra enhetliga bedömningar av förhållandet mellan brott och straff på ett sätt som tillgodoser intresset av rättvisa bestraffningar och en begränsning av statens bestraffande makt. Utredningen granskar därför prThis thesis examines how the principle of proportionality is used in a law proposal that suggests increased penalties. It aims to problematize if the principle of proportionality can ensure stable assessments of the relationship between crime and punishment in a way that satisfies the interest of fair punishment and that limits the punitive power of the state. It is therefore interested in examini

I studien undersöks utmaningar och förbättringsförslag relaterade till arbetsmiljö, säkerhet och kommunikation inom byggindustrin för utländska arbetstagare, med extra fokus på länderna Polen och Litauen. Fri rörlighet för arbetstagare inom EU, som fastställs av artikel 45 i EUF-fördraget, möjliggör lika tillgång till både arbetsmöjligheter och behandling oavsett nationalitet. Syftet med studien The study examines challenges and improvement suggestions related to the work environment, safety, and communication within the construction industry for foreign workers, with a particular focus on Poland and Lithuania. The free movement of workers within the EU, as established by Article 45 of the treaty on the functioning of the European Union, ensures equal access to both employment opportuniti

The city of Milan stands today as a prominent model of sustainable urban development. Yet, beneath its allure lies a paradox: the quest for 'green' and 'smart' development has exacerbated privatization and fueled debates on green gentrification, social equity, and urban accessibility. This research explores the emerging impacts of large-scale green urbanization intervention in the

Chemokine receptor CX3CR1(+) dendritic cells (DCs) have been suggested to sample intestinal antigens by extending transepithelial dendrites into the gut lumen. Other studies identified CD103(+) DCs in the mucosa, which, through their ability to synthesize retinoic acid (RA), appear to be capable of generating typical signatures of intestinal adaptive immune responses. We report that CD103 and CX3C

New basis sets of the atomic natural orbital (ANO) type have been developed for the lanthanide atoms La-Lu. The ANOs have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive ions, and the atom in an electric field. Scalar relativistic effects are included through the use of a Douglas-Kroll-Hess Hamiltonian. Multiconfigurational wave funct