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VINTERGATAN-GM : How do mergers affect the satellite populations of MW-like galaxies?

We investigate the impact of a galaxy’s merger history on its system of satellites using the new VINTERGATAN-GM suite of zoom-in hydrodynamical simulations of Milky Way-mass systems. The suite simulates five realizations of the same halo with targeted ‘genetic modifications’ of a z ≈ 2 merger, but resulting in the same halo mass at z = 0. We find that differences in the satellite stellar mass func

Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity

CONTEXT: Cardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual cardiometabolic diseases; however, their associations with CM and related biological markers are unknown.METHODS: This prospective study involved 172 315 (for caffeine analysis) and 1

Licence to Regulate: Article 114 TFEU as Choice of Legal Basis in the Digital Single Market

This chapter discusses Article 114 TFEU as the choice of legal basis in the Digital Single Market. It argues that the EU’s competence in the internal market has developed into a default option for harmonising measures in digitalisation, exacerbated by the Union’s new regulatory approach. With particular reference to the area of competition law and the recently introduced Digital Markets Act, Artic

Particle rotations and energy dissipation during mechanical compression of granular materials

We present new in-situ measurements of particle rotations and energy dissipation during compression of 3D packings of stiff, frictional particles. Two confined, uniaxial compression tests with different degrees of lateral confinement are discussed. X-ray computed tomography and 3D X-ray diffraction were combined to provide inter-particle forces, slip and roll distances, twist angles, and energy di

The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis

Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve

The hegemony of integrated water resources management as a global water discourse

The early form of Integrated Water Resources Management (IWRM) emerged in the USA in the 1900s in order to manage interactions between water, land, eco- and social systems. By the end of the last century, IWRM has become a globally prominent policy concept. We concern ourselves with three questions, namely, a) “why did IWRM become a globally popular concept”?; b) “how did IWRM become a globally po

Interpretation of serological complement biomarkers in disease

Complement system aberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complementrelated differe

Surface Engineering of Quantum Dots for Remarkably High Detectivity Photodetectors.

Ternary alloyed CdSexTe1–x colloidal QDs trap-passivated by iodide-based ligands (TBAI) are developed as building blocks for UV–NIR photodetectors. Both the few surface traps and high loading of QDs are obtained by in situ ligand exchange with TBAI. The device is sensitive to a broad wavelength range covering the UV–NIR region (300–850 nm), showing an excellent photoresponsivity of 53 mA/W, a fast

Age-resolved chemistry of red giants in the solar neighbourhood

In the age of high-resolution spectroscopic stellar surveys of the Milky Way, the number of stars with detailed abundances of multiple elements is rapidly increasing. These elemental abundances are directly influenced by the evolutionary history of the Galaxy, but this can be difficult to interpret without an absolute timeline of the abundance enrichment. We present age-abundance trends for [M/H],

DICHOTOMY RESULTS FOR EVENTUALLY ALWAYS HITTING TIME STATISTICS AND ALMOST SURE GROWTH OF EXTREMES

Suppose (f,X, μ) is a measure preserving dynamical system and φ: X → R a measurable function. Consider the maximum process Mn := max{X1, ,Xn}, where Xi = φ ○ fi-1 is a time series of observations on the system. Suppose that (un) is a non-decreasing sequence of real numbers, such that μ(X1 > un) → 0. For certain dynamical systems, we obtain a zero- one measure dichotomy for μ(Mn ≤ un i.o.) dependin

Economic Organizations and the Transformation Towards Degrowth

Degrowth seeks to achieve a sustainable society in the future. It implies overcoming capitalist norms and structures. Economic organizations have found little attention in degrowth scholarship. The existing literature focuses on degrowth compatibility without the wider structural and societal consideration that degrowth implies. Further, it is riddled with incoherences, such as a supposed compatib

A new mass and radius determination of the ultra-short period planet K2-106b and the fluffy planet K2-106c

Ultra-short period planets (USPs) have orbital periods of less than 1 d. Since their masses and radii can be determined to a higher precision than long-period planets, they are the preferred targets to determine the density of planets which constrains their composition. The K2-106 system is particularly interesting because it contains two planets of nearly identical masses. One is a high-density U

Sweden, Russia, and the 1617 Peace of Stolbovo

In 1617, after seven years of war between Sweden and Russia and talks facilitated by English and Dutch diplomats, the peace treaty of Stolbovo was signed. This important but little-studied document was to form the basis for relationships between Sweden and Russia for the next one hundred years, before it was replaced by the Peace of Nystad in 1721, and it had a huge influence on the lives of the p

Tragedy of the facilitated commons: A multiple case study of failure in systematic horizontal logistics collaboration

Horizontal logistics collaboration can increase environmental sustainability and reduce shipping costs. Given these benefits—and the fact that few shippers actually opt to collaborate—public sector agencies and industry associations have attempted to sponsor and support the facilitation of horizontal logistics collaboration projects over the past 20 years. The literature, however, has yet to revea

Dietary-based developmental plasticity affects juvenile survival in an aquatic detritivore

Developmental plasticity is ubiquitous in natural populations, but the underlying causes and fitness consequences are poorly understood. For consumers, nutritional variation of juvenile diets is probably associated with plasticity in developmental rates, but little is known about how diet quality can affect phenotypic trajectories in ways that might influence survival to maturity and lifetime repr

Validation of the 4-item PRECISE-DAPT score : A SWEDEHEART study

BACKGROUND: The Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE-DAPT) score has been shown to predict out-of-hospital major bleeding after myocardial infarction treated with percutaneous coronary intervention and dual antiplatelet therapy (DAPT). However, large validation studies have been scarce and the discriminative a

Supernova explosions in active galactic nuclear discs

Active galactic nuclei (AGNs) are prominent environments for stellar capture, growth, and formation. These environments may catalyse stellar mergers and explosive transients, such as thermonuclear and core-collapse supernovae (SNe). SN explosions in AGN discs generate strong shocks, leading to unique observable signatures. We develop an analytical model that follows the evolution of the shock prop

'Mom might have a job (or be socializing too much!)' : 'The right to love', children's sexuality and parenthood

Having been unavailable for many years, the Swedish film Rätten att älska (‘The right to love’) was restored by the Swedish Film Institute in 2013 and made accessible for research. In many ways a typical example of the sex education film genre of its time, the film is simultaneously unusual because it deals with children’s sexuality. This article explores and discusses the representation of childr