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BACKGROUND: Folate is involved in DNA synthesis and methylation and may thereby influence carcinogenesis. OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C<--T (rs1801133) and 1298A<--C (rs1801131)]. We also explored whether P-folate was associated with risk of postmenopausal bre

B-cell development into antibody producing cells is a complex process that relies on the tightly controlled production of hundreds of genes and proteins. A B-cell is activated through the B-cell receptor (BCR) and this activation is modified by different co-stimulatory or inhibitory co-receptors. The concerted action of signals from BCR and from co-receptors decides the fate of the B-cells. The ma

Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both

Treatment and management of chronic wounds is a large burden on the health sector and causes substantial suffering for the patients. We believe that 13 lactic acid bacteria (LAB) symbionts isolated from the honey crop of the honeybee are important players in the antimicrobial action of honey, by producing antimicrobial substances and can be used in combination with heather honey as an effective tr

Broadening conventional sociological concerns, this paper establishes a social psychological account of queer theory, and an associated understanding of subject formation, in order to examine the relationship between the continuously emerging self and the dressed body by taking its departure in the concept and phenomenon of cross-dressing. Focusing the interrelationship between bodily gestures and

Adequate cleavage of von Willebrand factor (VWF) prevents formation of thrombi. ADAMTS13 is the main VWF-cleaving protease and its deficiency results in development of thrombotic microangiopathy. Besides ADAMTS13 other proteases may also possess VWF-cleaving activity, but their physiological importance in preventing thrombus formation is unknown. This study investigated if, and which, proteases co

Bed joint reinforcement consisting of unprotected carbon steel was widely used to bridge windows and other openings in post-war brick buildings in the Scandinavian countries. Today, cracking caused by reinforcement corrosion constitute an increasing technical and economic problem, since removal of the corroding reinforcement can be both labour intensive and costly. Retrofitting measures are usuall

Purpose: Substance use disorders and problematic substance use are common problems in adolescence and young adulthood. Brief personalized feedback has been suggested for treatment of alcohol and drug problems and poor mental health. This repeated measurement randomized controlled trial examines the effect of an interactive voice response (IVR) system for assessing stress, depression, anxiety and s

Cellulose, one of the most abundant renewable resources, is insoluble in most common solvents but dissolves in aqueous alkali under a narrow range of conditions. To elucidate the solubilization mechanism, we performed electrophoretic NMR on cellobiose, a subunit of cellulose, showing that cellobiose acts as an acid with two dissociation steps at pH 12 and 13.5. Chemical shift differences between c

Popular Abstract in Swedish Olika toleransmekanismer kontrollerar immunsystemets aktivitetThe immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. This thesis work is based on investigations of different tolerance mechanisms induced in CD4+ T lymphocy

The social dimensions of the great transformation from an agrarian to an industrial society are still poorly understood. Today there are challenging opportunities to study such processes in Asia, and to do this against a comparative background of similar transformations elsewhere, for example in Europe, and in the light of theories of social mobility, industrialisation and agrarian change. This st

The Swedish concept of folkbildning (the ‘bildung’ of the people) and its introduction in the mid-1900th century was connected to the advent of Folkhögskolan (the popular adult education) with explicit as well as implicit references to the Danish philosopher Gruntvig’s ideals of education. The broad popular movement which the adult education ideals was incorporated into during the beginning of the