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Immunoglobulin kappa promoters were collected from mice and man. It was shown that they had homology within but not between subgroups, and the promoters were also conserved between species. The octamer element was found in all promoters, but other sequence elements were conserved within the distinct subgroups. E-boxes were found in most promoters and were usually of the E2A type. A mouse kappa pro
Popular Abstract in Swedish Det finns ett stort behov av molekyler eller reagenser för korrekt och snabb diagnos och/eller behandling av sjukdom. På laboratorier används särskilda verktyg för att ta fram sådana reagenser. Verktygen utgörs ibland av levande organismer, som t ex bakterier och virus, och kallas bioteknologiska verktyg. Ett av dessa verktyg baseras på användandet av en speciell typ avPhage display technology is a biotechnological tool that can be used to obtain molecules/reagents able to discriminate between target molecules. Reagents with such features can be used in diverse settings like biological chemistry, diagnostics and in therapeutic applications. Phage display technology is based on the use of recombinant DNA technology, bacteria and a special kind of bacterial virus,
Sweden’s reception of Thomas Kuhn’s ‘The Structure’ did not differ significantly from other countries. In general terms, its enormous impact was based on three factors. A) ‘The Structure’ justified sociological investigations of the contents of science. Thus it opened up a new area of research, called the Sociology of Scientific Knowledge, Social Studies of Science, Post-Kuhnian Sociology of Scien
Dendritic cells (DC) are a heterogeneous lineage of bone-marrow-derived leukocytes that serve as the link between innate and adaptive immunity. They are professional antigen-presenting cells that play an important protective and regulatory role in both health and disease. This thesis is based upon six original papers that deal with the function and transcription of human DCs, with focus on their r
Directions are given for demonstrating various topics from the other book chapters: The wave-nature of light, singlet oxygen, chromatic adaptation of cyanobacteria, the properties of the human visual system, photoconversion of rhodopsin, photosynthesis of previtamin D, spectral properties of chlorophyll, photoconversion of protochlorophyllide, separation of chloroplast pigments, photoadaptation of
We report the first high spectral resolution study of 17 M giants kinematically confirmed to lie within a few parsecs of the Galactic center, using R ~ 24,000 spectroscopy from Keck/NIRSPEC and a new line list for the infrared K band. We consider their luminosities and kinematics, which classify these stars as members of the older stellar population and the central cluster. We find a median metall
Crisis preparedness planning work can be characterized as complex and challenging being performed in large public organizations requiring communication and cooperation with many people. This paper reports on a bottom-up study investigating the pre-requisites for efficient crisis preparedness work, as well as motivational factors for implementing crisis preparedness decisions, which might be studie
To a higher degree, older adults will live to old age in their own homes with the assistance of home care services. One effect of this is an increased number of people working in the home environment. This paper presents the results from a research project that studied the physical environment in Swedish home care. Innovations to support the home care situation were developed, with the aim of cont
The majority of research in second language acquisition has traditionally focused on classroom-based, instructed learning. However, with the spread of new technologies and the concomitant globalisation of popular culture, informal second language practices (ISLPs; e.g. watching films and television, using social media, or playing video games in another language) are increasingly becoming part of t
Structural Health Monitoring (SHM) systems are designed for assisting owners and operators with information and forecasts concerning the fitness for purpose of structures and building systems. The benefit associated with the implementation of SHM may in some cases be intuitively anticipated or proven by past experiences but in general there appears to be no rational or systematic approach for asse
Conventional road accident risk is measured by the undesirable events/exposure ratio. Common exposure indicators are activity-based, so event-based exposure is needed to achieve event-based safety assessment. Furthermore, road safety simulation is a growing research field. The influence of some software parameters is still unknown. Besides, the use of simulation for exposure assessment is incipien
Sizeable number of stellar-mass black holes (BHs) in globular clusters (GCs) can strongly influence the dynamical evolution and observational properties of their host cluster. Using results from a large set of numerical simulations, we identify the key ingredients needed to sustain a sizeable population of BHs in GCs up to a Hubble time. We find that while BH natal kick prescriptions are essential
