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There is a clinical need for improved wound treatments that prevent both infection and excessive inflammation. TCP-25, a thrombin-derived peptide, is antibacterial and scavenges pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide, thereby preventing CD14 interaction and Toll-like receptor dimerization, leading to reduced downstream immune activation. Here, we describe the de
The idea that noncrop habitat enhances pest control and represents a win–win opportunity to conserve biodiversity and bolster yields has emerged as an agroecological paradigm. However, while noncrop habitat in landscapes surrounding farms sometimes benefits pest predators, natural enemy responses remain heterogeneous across studies and effects on pests are inconclusive. The observed heterogeneity
Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. A strategy to achieve this is to use phage display antibody libraries and selection on
The atrioventricular (AV) node plays a central role during atrial fibrillation (AF). We have recently proposed a statistical AV node model defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the dual AV nodal pathways, the refractory periods of the pathways, and the prolongation of refractory periods. All model parameters a
We propose a technique to generate non-projective word orders in an efficient statistical linearization system. Our approach predicts liftings of edges in an unordered syntactic tree by means of a classifier, and uses a projective algorithm for tree linearization. We obtain statistically significant improvements on six typologically different languages: English, German, Dutch, Danish, Hungarian, a
In the concluding chapter, the editors take stock of the state of integration seventy years after the EU’s inception. In the early 2020s, the EU faces once again the fateful question of whether integration should proceed in a federal direction, or whether varied flexible solutions to concrete problems should guide its development instead. The stock-taking is seen against the acute challenges that
Food loss and waste are major issues in the food industry, and they affect all stages of the food supply chain (FSC). Food loss and waste are linked to environmental deterioration, economic loss, and an increase in hunger. Therefore, the food industry requires sustainable consumption and production (SCP) to reduce losses and waste. The circular economy (CE) concept has become a popular strategy fo
Sammanfattning Det är enbart arbetstagare som omfattas av det arbetsrättsliga skyddet i lagstiftningen. Därmed utgör arbetstagarbegreppet en viktig del av arbetsrätten. Definitionen av begreppet får en allt större betydelse då sättet att organisera arbetet förändras kontinuerligt i och med att nya anställningsformer tillkommer. Uppsatsen undersöker hur EU och Sverige definierar och tillämpar arbAbstract The Labour law protection only covers those who are considered employees. Thus, the concept of employee is a significant part of the Labour law. The definition is becoming increasingly important as the way of organizing the work is continuously changing as new forms of employment are added. The essay examines how the EU and Sweden define and apply the concept of employee and what similar
Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decrea
Sexual selection hypotheses stipulate that the major histocompatibility complex genes (MHC) constitute a key molecular underpinning for mate choice in vertebrates. The last four decades saw growing empirical literature on the role of MHC diversity and dissimilarity in mate choice for a wide range of vertebrate animals, but with mixed support for its significance in natural populations. Using forma
List of scholarships and grants Page 1 of 76 List of scholarships and grants – offered by foundations connected with Lund University Finance Endowment administration Emma Haverlind, administrator 2025-02-12 Postal address Box 117, 221 00 Visiting address Sandgatan 5 Telephone +46 222 71 44, +46 46 222 00 00 E-mail stipendier@eken.lu.se Website www.lunduniversity.lu.se, www.staff.lu.se Page 2 of 76
https://www.staff.lu.se/sites/staff.lu.se/files/2025-02/List%20of%20scholarships%20and%20grant%20250212.pdf - 2026-05-23
Objective: To describe the electrophysiological characteristics and pathophysiological significance of electrographic status epilepticus (ESE) after cardiac arrest and specifically compare patients with unequivocal ESE to patients with rhythmic or periodic borderline patterns defined as possible ESE. Methods: Retrospective cohort study of consecutive patients treated with targeted temperature mana
Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodies against CGRP and its binding site at the receptor are clinically effective in p
Background: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown. Results: Using the flow cytometry technique for detection of P. falciparum specific (Pf+) B-cells, this study for the first time measured the development of Pf+ B cell (CD19+) phenotypes in Ugandan babies from birth
