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Popular Abstract in Swedish Genetisk påverkan i ledgångsreumatism Ett väl fungerande immunsystem är en förutsättning för kroppens kamp mot diverse sjukdomar orsakade av t ex virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Ibland fungerar inte denna diskriminering som den ska och In this thesis the role of major histocompatibility complex (Mhc) class II molecules in development of autoimmune disease such as rheumatoid arthritis (RA), was studied. By combining an experimental model for RA, collagen type II induced arthritis (CIA), with molecular biology methods the importance of polymorphism in Mhc class II genes for disease development was investigated. The Mhc region con

Phototoxicity occurs when a substance is toxic only under the action of light, and can, depending on the mechanism of toxic action, be divided into type I and type II phototoxicity. Other types are sometimes recongnized, and sometimes toxicity occurs through more than one mechanism. Plants often use phototoxins for their defense. They may be harmful to man, but also exploited for medical treatment

In this talk we show some potential applications of a pair of conventional double positive (DPS) and single negative (SNG) metamaterial blocks for specific patch antennas. We propose two designs. One is a 900- and 1800-MHz dual-band rectangular patch antenna filled with a pair of juxtaposed DPS and mu-negative (MNG) metamaterial blocks. With proper constitutive parameters and filling ratio of the

The paper presents a feedback scheduling mechanism in the context of co-design of the scheduler and the control tasks. We are particularly interested in controllers where the execution time may change abruptly between different modes, such as in hybrid controllers. The proposed solution attempts to keep the CPU utilization at a high level, avoid overload, and distribute the computing resources eve

Spontaneous data from Swedish are presented which suggest that ‘creaky voice’ associated with the filler EH ‘UH’ is related to the realization of the speaker attitude ‘uncertainty’ in the sense of ‘indecisiveness’ as regards the optimal way to linguistically code referents and predicates. It is suggested that creaky fillers express a certain degree of speaker indecisiveness as regards the most rel

The reassignment technique is used to increase the localization for signals that have closely located time-frequency components. For Gaussian components the reassignment based on an optimal (matched) window spectrogram will result in a single point where all mass is located. For non-optimal windows, the reassignment procedure can be optimally rescaled to fulfill the single point mass location. Non

The humoral immune response to a T cell dependent protein antigen will over time generate antibodies with an increased affinity to the antigen. This is due to a process known as affinity maturation and proceeds in a, for this purpose, well designed micro-milieu within secondary lymphoid organs known as germinal centres. The increase in affinity of an antibody in, e.g. mouse and man is due mainly t

AIMS: The sural nerve is the commonest peripheral nerve biopsied to help in the diagnosis of peripheral neuropathy of unknown cause. However, associated complications limit its use. The aim was, as an alternative, to asses biopsy of the terminal branch of the posterior interosseous nerve (PIN) in the forearm. METHODS: PIN pathology was morphometrically quantified in 10 male patients with Type 2 di

Artikeln diskuterar en väsentligen nordamerikansk tanketradition som explicit eller implicit framställer den centrala antika filosofiska frågan – ”hur bör jag leva?” – som sin frågehorisont, och som gör det såväl teoretiskt, empiriskt som normativt. Det handlar om sociologer och andra samhällsvetare, men också om litteraturvetare och kulturkritiker, essäister och skönlitterära författare. ArtikelnThe article describes and analyses an essentially American intellectual tradition which explicitly or implicitly poses the central question of Hellenistic and Roman philosophy – ”how should I live?” – as its main theme and concern, and which discusses the matter theoretically, empirically, and normatively. The tradition includes sociologists and other social scientists, but also cultural theorists

High-grade gliomas are one of the most aggressive human tumors with <1% of patients surviving 5 years after surgery. Immunotherapy could offer a possibility to eradicate remnant tumor cells after conventional therapy. Experimental immunotherapy can induce partial cure of established intracerebral tumors in several rodent models. One reason for the limited therapeutic effects could be immunosuppres

Landfilling is the most commonly used method for solid waste disposal in Jordan. It is an important source of pollution, which can be displayed through analysis of data for climatic conditions, hydrology and geology of the country. The migration of gas and leachate from the landfill body into the surrounding environment present a serious environmental concern, which include groundwater pollution,

The identification of serum biomarkers for the diagnosis of inflammatory bowel diseases able to reduce the need for invasive tests represents a major goal in their therapy and follow-up. We report here a methodological approach for the evaluation of specific changes in the serum peptides abundance in healthy (H) and Crohn's disease (CD) subjects, based on a label-free LC ESI/Q-TOF differential mas

A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of ageing. As stem cells regulate tissue homeostasis, depletion of stem cell reserves and/or diminished stem cell function have been postulated to contribute to ageing. It has further been suggested that accumulated DNA damage could be a principal mechanism underlying age-dependent stem cell decline. We

This paper studied associations between ocular symptoms, rhinitis, throat and dermal symptoms, headache and fatigue in students by ethnicity and in relation to exposure to chemical microbial markers and fungal DNA in vacuumed dust in schools in Malaysia. A total of 462 students from 8 randomly selected secondary schools in Johor Bahru, Malaysia, participated (96% response rate). Dust was vacuumed