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Studies on Prostanoid Production in the Umbilicoplacental Circulation

Popular Abstract in Swedish Prostaglandiner och tromboxaner är hormonliknande ämnen som består av cykliska fleromättade fettsyror. Karakteristiskt för alla prostaglandiner är att de har en mycket kort halveringstid, de verkar lokalt, kan ej lagras i vävnader och att produktionen hämmas av aspirin (acetylsalicylsyra). Prostacyklin och tromboxan är två prostaglandiner med i stort sett motsatta effekThe fetoplacental circulation is a low pressure system with a high vascular prostacyclin to thromboxane (Pc/Tx)synthesis ratio. In intrauterin growth restriction (IUGR) and diabetes the prostanoid balance may be altered. AIMS: To investigate relationships between umbilicoplacental vascular prostanoid synthesis (by incubation of vessel samples), circulatory changes (by Doppler velocimetry of umbili

Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors

Galectin-3 is extensively involved in metabolic and disease processes, such as cancer metastasis, thus giving impetus for the design of specific inhibitors targeting this -galactose-binding protein. Thiodigalactoside (TDG) presents a scaffold for construction of galectin inhibitors, and its inhibition of galectin-1 has already demonstrated beneficial effects as an adjuvant with vaccine immunothera

High-mobility group box protein 1 and its signalling receptors in human preterm and term cervix

The objective of this study was to identify possible changes in mRNA and protein expression of high-mobility group box protein 1 (HMGB1) and its suggested receptors - receptor for advanced glycation end-products (RAGE) and Toll-like receptor 2 (TLR2) and TLR4 - in human cervix during pregnancy, term and preterm labor. Cervical biopsies were taken from 58 women: 20 at preterm labor, 24 at term labo

Beyond the Usual Suspects: Critically Informed Research.

A number of researchers have attempted to define and encapsulate the essence of ‘critical research’. It has been suggested to encompass interpretation of social phenomena, and seeks for understandings that could support efforts to bring about beneficial change. It has been further suggested that such work is characterised by: concern with substantive social issues (e.g. power, values); foundation

Grundämnessammansättning i olika partikelstorleksfraktioner av den atmosfäriska aerosolen

Beskrivning ges av analysteknik (protoninducerad röntgenstrålning), provtagningsteknik (kaskadimpaktor av Battelle-typ) och provberedningsteknik. Utfört arbete i form av provbehandlingsförbättringar, konstruktion och förbättring av provtagare, bestämning av lämpliga analysparametrar samt uppbyggnad av ett dataprogramsystem presenteras. Sammanställning av resultat i form av beräknade medelvärden i

Domsrätt och lagval vid elektronisk handel

Popular Abstract in Swedish Vilket lands domstolar är behöriga att lösa tvister som kan uppkomma till följd av elektroniska avtal där parterna hör hemma i olika länder? Vilket lands lag skall domstolen använda? Även om en svensk domstol är behörig är det inte säkert att den skall använda svensk lag. Dessa frågor sorterar inom ett ämnesområde som heter interationell privat- och processrätt. I avhanThis study addresses some of the private international law perspectives on electronic commerce, namely the matters of jurisdiction and choice of law. Electronic commerce is based on the formation of contracts, and when there are contracts, questions regarding legal issues arise. A distinctive trait of electronic business is that its activities are not bound by geographic borders in a traditional s

The SystemJ approach to system-level design

In this paper, we propose a new system-level design language, called SystemJ. It extends Java with synchronous reactive features present in Esterel and asynchronous constructs suitable for modelling globally asynchronous locally synchronous systems. The strength of SystemJ comes from its ability to offer the data processing and encapsulation elegance of Java, Esterel-like reactivity and synchrony,

The use of routine ultrasound in pregnancy : with special reference to normal and abnormal foetal growth, information and informed choice and the womens' experiences of the prenatal diagnostic aspects

The development of real-time ultrasound in the 1970's made indelible inpact on antenatal care. Assessing foetal growth and detecting deviations from normal in both growth and foetal anatomy became fesible. Expectant parents could also 'see' their foetus. Normal foetal growth parameters at term were consituted and selected parameters from the second trimester were evaluated in the detection of chro

Inbreeding affects gene expression differently in two self-incompatible Arabidopsis lyrata populations with similar levels of inbreeding depression.

Knowledge of which genes and pathways are affected by inbreeding may help understanding the genetic basis of inbreeding depression, the potential for purging (selection against deleterious recessive alleles) and the transition from outcrossing to selfing. Arabidopsis lyrata is a predominantly self-incompatible perennial plant, closely related to the selfing model species A. thaliana. To examine ho

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

BACKGROUND: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization.METHODS: We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze the pathology of invasive breast, ovarian, and contralateral breast cancers.RESULTS: There was strong evidence t

Photodissociation Dynamics of Iodoform in Solution.

The photodissociation dynamics of iodoform (CHI3) in acetonitrile and cyclohexane were investigated by femtosecond pump-probe spectroscopy and nanosecond laser flash photolysis. We have measured transient absorption spectra in the spectral region of 370-730 nm and kinetics at selected wavelengths on a femtosecond-microsecond time scale. We assign the observed photoproduct with absorption maxima at

Reliability test-retest of the Nordic Assisted Mobility Evaluation (NAME 1.0).

This paper describes preliminary results from the test-retest of the NAME 1.0. Four scales were tested: Mobility-related participation frequency; Mobility ease/difficulty; Mobility dependence; Extent of assistance in mobility. The test was conducted in the five Nordic countries. In all 147 mobility device users took part in the study, mean age 60 years (range 19 - 93). Each participant was intervi