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Previous studies have used recombinant adeno-associated viral (rAAV) vectors to deliver glial cell line-derived neurotrophic factor (GDNF) in the substantia nigra to protect the nigral dopamine (DA) neurons from 6-hydroxydopamine-induced damage. However, no regeneration or functional recovery was observed in these experiments. Here, we have used an rAAV-GDNF vector to express GDNF long-term (6 mon

A combined sample preparation and sample presentation device, Integrated Selective Enrichment Target (ISET), consisting of an array with 96 perforated nanovials is described. Each perforated nanovial can be filled with soild-phase extraction media for purification and concentration of biomolecules prior to mass spectrometry. The ISET platform provides an efficient, economic and generic sample trea

Recently, we constructed a focused antibody library tailored to interact with haptens. High functionality of this library was demonstrated, as specific binders could be retrieved to a range of different haptens. In the current study we have developed a mutagenesis and selection strategy in order to further fine-tune the hapten binding properties of these antibody fragments. Testosterone was chosen

Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well a

Understanding of Forster resonance energy transfer (FRET) in thin films composed of quantum dots (QDs) is of fundamental and technological significance in optimal design of QD based optoelectronic devices. The separation between QDs in the densely packed films is usually smaller than the size of QDs, so that the simple point dipole approximation, widely used in the conventional approach, can no lo

The aim of this sociology of law-orientated article is to analyse and describe legislative and regulatory processes concerning the task given to schools focusing on environment and sustainable development. We are describing the policy-making processes in this field from 1990 to 2011. The study involves key interviews and content analysis of national policy documents as well as legal sources, in or

This chapter does not deal with any practical aspects of light measurement, only with theoretical concepts. The following concepts are explained: energy fluence, energy fluence rate, photon fluence, photon fluence rate, radiance and mol, as well as the following superfluous or obsolete terms and synonyms: actinic flux, space irradiance, scalar irradiance, spherical irradiance, vectorial irradiance

We are good at discussing law statements of different epistemic status, and to describe logical relationships between different law statements. But contemporary discussion often suffers from a difficulty to formulate questions concerning laws of different ontological status. This paper presents a framework for distinguishing between properties and fake properties that seems to provide better tools

This paper describes trade-offs involved in designing a dual-band CMOS frontend for wireless local-area network (WLAN). Three 0.18μm CMOS frontends have been investigated, a single-band frontend at the 2.4 GHz ISM band, a single-band frontend at the 5 GHz U-NII band and a dual-band frontend. The study shows that employing a dual-band frontend yields satisfactory results, although some compromises