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BackgroundLittle data exist on real-world treatment patterns in psoriasis, especially from European settings. ObjectiveTo estimate, for topicals, systemics and biologics, the time to non-persistency, switching, augmentation and insufficient treatment result (only for biologics), as well as to estimate the time to restart, in patients treated with each treatment class in Sweden based on registry da

Orthostatic hypotension (OH) is a common cardiovascular disorder, with or without signs of underlying neurodegenerative disease. OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/diastolic blood pressure decrease of at least 20/10 mm Hg upon standing. Its prevalence is age dependent, ranging from 5% in patients <50 years of age to 30% in those >70 years of

Santiago was one of the first cities outside the OECD to implement a tradable permit program to control air pollution. This article looks closely at the program's performance over the past 10 years, stressing its similarities and discrepancies with trading programs implemented in developed countries and analyzing how it has reacted to regulatory adjustments and market shocks. Studying Santiago's e

The development of high-performance technology platforms for generating detailed protein expression profiles, or protein atlases, is essential. Recently, we presented a novel platform that we termed global proteome survey (GPS), where we combined the best features of affinity proteomics and mass spectrometry, to probe any proteome in a species independent manner while still using a limited set of

Internal erosion is a cause of embankment dam failure, thus it is important to develop methods for seepage monitoring and internal erosion detection. In order to evaluate the potential of resistivity monitoring to give an early warning of such leakage/erosion, a test was undertaken on a rockfill embankment dam with a central glacial till core at the Rossvatn test facility in Norway. Three defects,

The Muhammad cartoon crisis in 2005 provides an illustrative example of how crises travel across geographical boundaries, in this case, from a national newspaper into a full-fledged public diplomacy crisis at the international level. From a crisis management perspective, a multilevel setting poses a real challenge to actors trying to contain the situation at hand. Likewise, the multilevel nature o

The most critical functions of the various proteomics organisations are the training of young scientists and the dissemination of information to the general scientific community. The education committees of the Human Proteome Organisation (HUPO) and the European Proteomics Association (EuPA) together with their national counterparts are therefore launching the International Proteomics Tutorial Pro

Proteins of the signal crayfish Pacifastacus leniusculus egg and spermatophore were identified using in-gel digestion, mass spectrometry, and Mascot search. Forty-one and one-hundred-fifty proteins were identified in egg and spermatophore, respectively. The proteins were classified into nine categories including cell defence, cell signaling, cytoskeleton, DNA related activity, metabolism and energ

The protective effect of a multi-strain probiotic and synbiotic formulation was evaluated in C57BL/6 mice infected with Clostridium difficile (CD) NAP1/027. Antibiotic treated mice were divided into four groups. Group 1, fed with a synbiotic formulation consisting of Lactobacillus plantarum F44, L. paracasei F8, Bifidobacterium breve 46, B. lactis 8:8, galacto-oligosaccharides (GOS), isomalto-olig

At first sight, international law seems to uphold both state sovereignty and individual sovereignty. The existence and autonomy of a state are secured by the obligation on other states to respect its territorial integrity and the prohibition on intervening in other states’ domestic affairs. At the individual level, internationally guaranteed human rights serve comparable functions: they secure a m

The following text addresses the ecological and cultural significance of the threats affecting the honey-bee, and which are becoming apparent through the unusual and sometimes drastic death rates of bee colonies. General research conducted on this problem largely agrees that the threats to bees are a syndrome that has a multifactorial nature and anthropogenic origin. In face of a plethora of relev

There are many possible definitions of “technology” and I will discuss some of these in this book. However, in this introduction let me use a definition of Svante Lindqvist who defines technology very intuitively as “those activities, directed towards the satisfaction of human wants, which produce change in the material world.” He says also “the distinction between human “wants” and more limited h