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Superantigens are immune-stimulatory toxins produced by Staphylococcus aureus, which are able to interact with host immune receptors to induce a massive release of cytokines, causing toxic shock syndrome and possibly death. In this article, we present the x-ray structure of staphylococcal enterotoxin B (SEB) in complex with its receptors, the TCR and MHC class II, forming a ternary complex. The st

Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has

Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle facto

Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly prioritized. To date, proposed in vitro assays are mainly based on single biomarkers, which so far have not been able to classify and stratify chemicals into subgroups, related to risk or potency

Generative product design systems used in the context of mass customization are required to generate diverse solutions quickly and reliably without necessitating modification or tuning during use. When such systems are employed to allow for the mass customization of product form, they must be able to handle mass production and engineering constraints that can be time-consuming to evaluate and diff

Abstract in UndeterminedSo-called fitting-attitude analyses or buck-passing accounts of value have lately received much attention among philosophers of value. These analyses set out from the idea that values must be understood in terms of attitudinal responses that we have reason to or that it is fitting or that we ought to have regarding the valuable object. This work examines to what extent this

This essay studies the depiction of landscape in Bergman's films in relation to traditional imagery in Swedish films. Bergman's landscapes are here regarded as an implicit criticism of the self-image of the Swedish model welfare state.

Three theoretical atomic structure projects of interest for the astrophysical community and the lightning industry which are partially finished will be presented. Extensive ab initio calculations of properties of astrophysical interest has been done or are under its way for Ga I, Ga II, Ga III, In II and In III. The aim of the project is to also make calculations for In I, Tl I, Tl II and Tl III.

Den under seklet föränderliga attityden till kyrkornas prydande med apokalyptiska bilder under 1700-talet behandlas.