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The Fragility of Religious Freedom

One implication of freedom of religion is that the State must accept a variety of religious beliefs and practices. Yet, not everything can be accepted. One way of dealing with such a conflict is to state that freedom of religion is absolute in so far that it does not infringe upon some other more important value. Another way is to limit what is considered ‘religious.’ Both these ways are insuffici

Variation of breast cancer risk among BRCA1/2 carriers

CONTEXT: The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers. OBJECTIVES: To determine the extent to which risks for BRCA1 and BRCA2 carriers vary with respect to observable and unobservable characteristics. DESIGN, SETTING, AND PARTICIPANTS: Probands

Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.

The SNP rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein. Autoantibodies (Ab) that recognize ZnT8R, ZnT8W or both at the polymorphic site are common in newly diagnosed type 1 diabetes (T1D) patients. The epitope specificity and affinity of ZnT8Ab are poorly understood, but may be of importance for the pred

Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes.

Gene fusions have been described in approximately one-third of soft tissue tumors (STT); of the 142 different fusions that have been reported, more than half are recurrent in the same histologic subtype. These gene fusions constitute pivotal driver mutations, and detailed studies of their cellular effects have provided important knowledge about pathogenetic mechanisms in STT. Furthermore, most fus

Properties of long gamma-ray bursts from massive compact binaries.

We consider the implications of a model for long-duration gamma-ray bursts in which the progenitor is spun up in a close binary by tidal interactions with a massive black-hole companion. We investigate a sample of such binaries produced by a binary population synthesis, and show that the model predicts several common features in the accretion on to the newly formed black hole. In all cases, the ac

Into the isle of self : Nietzschean patterns and contrasts in D.H. Lawrence's The trespasser

This thesis is based on a close reading of Lawrence's novel The Trespasser from a Nietzschean point of view. By adopting this perspective it aims at giving the novel the sense of unity it has so far been alleged to lack. The analysis is preceded by a detailed discussion of the concept of literary influence. Since the purpose of this study is to illuminate what is unique in Lawrence's novel rather

A force allocation strategy for dynamic positioning

A force allocation strategy used in connection with dynamic positioning of ships and semi-submersibels is presented. The strategy dynamically allocates force, and in case of azimuth thrusters - force directions, to a set of thrusters. The strategy handles n thrusters (n greater than or equal to 2) in an arbitrary configuration. The decision making of the strategy is based on minimum power consumpt

On the Efficient Estimation of Blood Velocities

Pulsed wave (PW) Doppler ultrasound systems are commonly used to examine blood flow dynamics and the technique plays a very important role in numerous diagnostic applications. Commonly, narrow-band PW systems estimate the blood velocity using an autocorrelation-based estimator. Herein, we examine a recently proposed hybrid frequency estimator, and via extensive numerical simulations using simulate

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.

HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex that induces apoptosis-like death in tumor cells, but leaves fully differentiated cells unaffected. This review summarizes the information on the in vivo effects of HAMLET in patients and tumor models, on the tumor cell biology, and on the molecular characteristics of the complex. HAMLET limits the progression of hu

LIFE SATISFACTION AND FEELING HINDERED BY HEALTH PROBLEMS AT 60 YEARS AND ABOVE

Popular Abstract in Swedish Idag finns det flera studier där livstillfredsställelse bland äldre har undersökts. Studierna är dels genomförda i varierande kontext och dels innehåller de varierande faktorer som hälsa, funktionell förmåga, självkänsla, sociala kontakter och finansiell situation. Därmed är det inte självklart att det finns gemensamma eller specifika faktorer, vilka är förknippade med The aim of this thesis was to investigate how older people's capacity to perform activities of daily living (ADL), health, social and financial resources, and self-esteem can be related to their life satisfaction. The aim was also to investigate how people feel hindered by health problems in relation to their ADL capacity, health problems, social and financial resources, self-esteem, sense of cohe

A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria

A human milk fraction containing multimeric alpha-lactalbumin (MAL) is able to kill cells via apoptosis. MAL is a protein complex of a folding variant of alpha-lactalbumin and lipids. Previous results have shown that upon treatment of transformed cells, MAL localizes to the mitochondria and cytochrome c is released into the cytosol. This is followed by activation of the caspase cascade. In this st

Preservatives in cosmetics in the Israeli market conform well to the EU legislation

BackgroundPreservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must be present on the product or packaging. ObjectivesTo examine the use of preservatives in common cosmetics on the Israeli

NK cell development and function - Plasticity and redundancy unleashed.

Bone marrow-derived natural killer (NK) cells constitute the major subset of cytotoxic lymphocytes in peripheral blood. They provide innate defense against intracellular infection or malignancy and contribute to immune homeostasis. Large numbers of NK cells are also present in tissues, including the liver and uterus, where they can mediate immunosurveillance but also play important roles in tissue