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Doxapram for the prevention and treatment of apnea in preterm infants

Background: Apnea of prematurity is a common problem in preterm infants that may have significant consequences on their development. Methylxanthines (aminophylline, theophylline, and caffeine) are effective in the treatment of apnea of prematurity. Doxapram is used as a respiratory stimulant in cases refractory to the methylxanthine treatment. Objectives: To evaluate the benefits and harms of doxa

How smart are electricity users with ‘Smart Metering’? A Behavioural Economics experiment

The purpose of this paper is to examine how behavioural biases affect consumers’ response to energy-use information provided through smart meters (SM). We take insights from behavioural economics and carry out two real-life experiments with SMs and electricity users. The experiments were conducted in Copenhagen (Denmark) to identify and assess the potential of two economic behavioural biases, sali

The Law and the Insane: Cases of Literary Censorship Involving the Mentally Insane During the Qianlong Reign

In a study on the problems of censorship and interpretation from 1984, (Censorship and Interpretation; The Conditions of Reading and Writing in Early Modern England), Annabel Patterson states that British authors of the seventeenth century often used the shelter of ambiguity as a protection from the threat of censorship. But as the text had to be understood by the intended readers, Patterson argue

Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis

Background: Juvenile idiopathic arthritis (JIA) is a rheumatic disorder that causes chronic joint inflammation beginning before the age of 16 years. Pharmacological treatment necessary to prevent joint destruction and functional impairment includes non-steroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DM

Biomarkers for the Early Detection of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma has one of the worst survival rates among adult cancers, with only 11% in the United States surviving five years after diagnosis. The majority of patients are diagnosed with late-stage disease, since early-stage pancreatic ductal adenocarcinoma is typically either asymptomatic or presents with non-specific symptoms. Pancreatic ductal adenocarcinoma thus remains a h

Cerebral near-infrared spectroscopy monitoring for prevention of death or neurodevelopmental disability in very preterm infants

RATIONALE: Very preterm infants (i.e. born before 32 weeks of gestation) are at risk of cerebral injury and long-term neurodevelopmental impairment. Cerebral near-infrared spectroscopy (NIRS) enables continuous monitoring of cerebral oxygenation to guide clinical management. Interest in NIRS has grown in recent years, highlighting the need for better evidence to support its clinical efficacy in im

3D DCIP techniques for detection of internal defects in the Älvkarleby test dam

This study explores the effectiveness of combining Electrical Resistivity Tomography (ERT) and Induced Polarization (IP) for identifying internal erosion processes in embankment dams. A small-scale test dam was built in Älvkarleby, Sweden, with deliberately embedded but undisclosed defects to test monitoring capabilities. Daily ERT and IP measurements were collected during 4.5-year years, and anal

The chemical evolution of the Galactic Bulge seen through micro-lensing events

Galactic bulges are central to understanding galaxy formation and evolution. Here we report on recent studies using micro-lensing events to obtain spectra of high resolution and moderately high signal-to-noise ratios of dwarf stars in the Galactic bulge. Normally this is not feasible for the faint turn-off stars in the Galactic bulge, but micro-lensing offers this possibility. Elemental abundance