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Simulating the mid-holocene, last interglacial and mid-pliocene climate with ec-earth3-lr

As global warming is proceeding due to rising greenhouse gas concentrations, the Earth system moves towards climate states that challenge adaptation. Past Earth system states are offering possible modelling systems for the global warming of the coming decades. These include the climate of the mid-Pliocene (∼ 3 Ma), the last interglacial (∼ 129-116 ka) and the mid-Holocene (∼ 6 ka). The simulations

Millimeter-Wave Massive MIMO Testbed with Hybrid Beamforming

Massive multiple-input multiple-out (MIMO) technology is vital in millimeter-wave (mmWave) bands to obtain large array gains. However, there are practical challenges, such as high hardware cost and power consumption in such systems. A promising solution to these problems is to adopt a hybrid beamforming architecture. This architecture has a much lower number of transceiver (TRx) chains than the to

Self-Interactions of Two Monoclonal Antibodies : Small-Angle X-ray Scattering, Light Scattering, and Coarse-Grained Modeling

Using light scattering (LS), small-angle X-ray scattering (SAXS), and coarse-grained Monte Carlo (MC) simulations, we studied the self-interactions of two monoclonal antibodies (mAbs), PPI03 and PPI13. With LS measurements, we obtained the osmotic second virial coefficient, B22, and the molecular weight, Mw, of the two mAbs, while with SAXS measurements, we studied the mAbs' self-interaction behav

Virtual cell model for osmotic pressure calculation of charged biomolecules

The osmotic pressure of dilute electrolyte solutions containing charged macro-ions as well as counterions can be computed directly from the particle distribution via the well-known cell model. Originally derived within the Poisson-Boltzmann mean-field approximation, the cell model considers a single macro-ion centered into a cell, together with counterions needed to neutralize the total cell charg

Developing eHealth in neonatal care to enhance parents' self-management

BackgroundDischarge from a neonatal care unit is often experienced as a vulnerable time for parents. By communicating through digital technology, it may be possible to improve the support for parents and thereby make the transition from hospital to home less stressful.AimTo develop an eHealth device supporting the transition from hospital to home for parents with a preterm‐born child in Sweden usi

Beam manipulation using characteristic mode analysis for switchable beam patch antenna

The operating mechanisms of a planar patch antenna with a parasitic strip is analyzed in this paper. The patch antenna uses a thin parasitic strip to realize beam deflection, which facilitates switchable beam. The beam deflection effect of the parasitic strip can be explained by using characteristic mode analysis (CMA). Specifically, the parasitic strip introduces a new mode that interacts with a

Artificial intelligence enabled radio propagation for communications – Part II: Scenario identification and channel modeling

This two-part paper investigates the application of artificial intelligence (AI) and in particular machine learning (ML) to the study of wireless propagation channels. In Part I, we introduced AI and ML as well as provided a comprehensive survey on ML enabled channel characterization and antenna-channel optimization, and in this part (Part II) we review state-of-the-art literature on scenario iden

Natural history and surgical outcome of Rathke's cleft cysts—A study from the Swedish Pituitary Registry

Objective: Rathke's cleft cysts are benign, embryological remnants in the pituitary gland. The majority of them are small and asymptomatic but a few may become large, and cause mass effects, pituitary hormone deficiencies and visual impairment. Recommendations for the follow-up of Rathke's cleft cysts vary since data on the natural history are sparse. Patients and Design: Data at diagnosis and at

Risk Factors for Fasciotomy After Revascularization for Acute Lower Limb Ischaemia

Background: Acute lower limb ischaemia (ALI) is a life and limb threatening vascular emergency. Acute compartment syndrome (ACS) may develop upon revascularization. The risk of fasciotomy was hypothesized to be decreased in women due to their lower calf muscle mass. The main aim was to evaluate risk factors for fasciotomy after revascularization for ALI. Methods: This is a retrospective observatio

The risk of chronic kidney disease in relation to anthropometric measures of obesity : A Swedish cohort study

Background: It has been shown that individuals with obesity have a higher risk for chronic kidney disease (CKD). However, it is unclear which measure of obesity is most useful for prediction of CKD in the general population. The aim of this large prospective study was to explore the association between several anthropometric measures of obesity, i. e., body mass index (BMI), waist circumference (W

Artificial intelligence enabled radio propagation for communications – Part I: Channel characterization and antenna-channel optimization

To provide higher data rates, as well as better coverage, cost efficiency, security, adaptability, and scalability, the 5G and beyond 5G networks are developed with various artificial intelligence techniques. In this two-part paper, we investigatethe application of artificial intelligence (AI) and in particular machine learning (ML) to the study of wireless propagation channels. It firstly provides a

Coupled Impacts of Atmospheric Circulation and Sea-Ice on Late Pleistocene Terrigenous Sediment Dynamics in the Subarctic Pacific Ocean

Processes controlling environmental change in the subarctic Pacific Ocean on millennial to orbital timescales are not well understood. Here we use a 230-kyr sedimentary record from the northwest Pacific Ocean to assess the response of late Pleistocene sediment dynamics to orbital forcing. Combining a source-to-sink perspective based on sedimentological records with climate model reanalysis, we rev

The effect of multisite phosphorylation on the conformational properties of intrinsically disordered proteins

Intrinsically disordered proteins are involved in many biological processes such as signaling, regulation, and recognition. A common strategy to regulate their function is through phosphorylation, as it can induce changes in conformation, dynamics, and interactions with binding partners. Although phosphorylated intrinsically disordered proteins have received increased attention in recent years, a

Challenges and solutions for antennas in Vehicle-to-Everything services

Autonomous vehicle is being developed for widespread deployment. Its reliability and safety are critically dependent on advanced wireless technologies, e.g., vehicle-to-everything (V2X) communication. The frontend of a V2X system needs an antenna module that enables the vehicle to reliably connect to all other networks. Designing V2X antenna is challenging due to the complex in-vehicle environment

The sarcopenia index measured using the lumbar paraspinal muscle is associated with prognosis in endometrial cancer

Objective: The number of type-II endometrial cancer patients has been increasing and the prognosis is not favorable. We aim to investigate whether sarcopenia index in any of several different muscles could serve as a novel biomarker of prognosis in patients with type-II endometrial cancer. Methods: We retrospectively investigated a total of 194 patients at four hospitals. Ninety patients were trea

FORWARD-BACKWARD SPLITTING WITH DEVIATIONS FOR MONOTONE INCLUSIONS

We propose and study a weakly convergent variant of the forward-backward algorithm for solving structured monotone inclusion problems. Our algorithm features a per-iteration deviation vector, providing additional degrees of freedom. The only requirement on the deviation vector to guarantee convergence is that its norm is bounded by a quantity that can be computed online. This approach offers great

Resilient Cloud Control: Securing, Adapting, and Thriving

This thesis delves into integrating control systems into cloud environments, leading to the emergence of what is commonly referred to as cloud control systems (CCSs). These systems represent a paradigm shift, leveraging the cloud’s expansive storage and computing capabilities to optimize industrial operations. However, while promising in terms of efficiency and scalability, this transition introdu

Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson's disease : a randomised controlled pilot study

BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal (HPA) axis. The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage (TM).DESIGN: Prospective, Control

Informing Static Mapping and Local Scheduling of Stream Programs with Trace Analysis

Due to their natural and inherent way of capturing concurrency, dataflow descriptions of stream programs have seen prevalent usage in fields such as video processing, networks and scientific computing. They are often deployed on manycore, heterogeneous and distributed architectures. Despite robust research on the topic, obstacles still exist in evaluating the performance of stream programs accurat