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Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Methods: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carr
Background: MR-generated acoustic noise may be particularly concerning at 7-Tesla (T) systems. Noise levels can be reduced by altering gradient output using software optimization. However, such alterations might influence image quality or prolong scan times, and these optimizations have not been well characterized. Purpose: To evaluate image quality, sound pressure levels (SPLs), and perceived noi
The global silicon (Si) cycle plays a critical role in regulating the biological pump and the carbon cycle in the oceans. A promising tool to reconstruct past dissolved silicic acid (DSi) concentrations is the silicon isotope signature of radiolaria (δ30Sirad), siliceous zooplankton that dwells at subsurface and intermediate water depths. However, to date, only a few studies on sediment δ30Sirad r
Climate warming has substantially advanced the timing of spring leaf-out of woody species at middle and high latitudes, albeit with large differences. Insights in the spatial variation of this climate warming response may therefore help to constrain future trends in leaf-out and its impact on energy, water and carbon balances at global scales. In this study, we used in situ phenology observations
This study, for the first time, assesses the impact of critical environmental factors on groundwater using Bayesian network (BN) integrated with analytical hierarchy process (AHP) and develops a groundwater vulnerability map. The considered environmental factors are divided into the following categories: physical (rainfall, temperature (Tmax/Tmin), relative humidity (RHmax/RHmin)), water use and d
The effects of insect herbivores on forest functioning are not well understood even though they can have important impacts on ecosystem processes by intercepting foliage before resorption and depositing nutrient-rich materials to the soil. In this thesis, I investigated the impact and drivers of insect folivores on carbon (C), nitrogen (N), phosphorus (P) and silica (Si) cycling in broadleaf fores
In this thesis, we focus on the problem of estimating receiver and sender node positions given some form of distance measurements between them. This kind of localization problem has several applications, e.g., global and indoor positioning, sensor network calibration, molecular conformations, data visualization, graph embedding, and robot kinematics. More concretely, this thesis makes contribution
Lake ice loss has been detected worldwide due to recent climate warming, yet spatially and temporally detailed information on the changes in global ice phenology does not exist. Here, we build a global lake ice phenology database comprising three lake ice phenologies—freeze-up, break-up, and ice duration—for each year across two centuries (1900–2099). The timing of all three phenologies experience
Background:The optimal treatment of displaced femoral neck fractures in patients 55 to 70 years old remains controversial. The aim of the present study was to assess the effect of closed reduction and internal fixation with cannulated screws (IF) compared with total hip arthroplasty (THA) on hip pain and function, with use of data for outcome measures, complications, and reoperations.Methods:This
Säker tillgång på vatten är en samhällsfråga som påverkar allt och alla i Sverige, skriver en rad vattenforskare och andra vattenexperter.
It is reported that the China–Pakistan Economic Corridor has been affected by extreme precipitation events. Since the 20th century, extreme weather events have occurred frequently, and the damage and loss caused by them have increased. In particular, the flood disaster caused by excessive extreme precipitation seriously hindered the development of the human society. Based on CRiteria Importance Th
This chapter provides overview of fundamental definitions, tools and new methods towards improved channel modeling reported in the Co-operation in Science and Technology (COST)-Inclusive Radio Communications (IRACON) Action for future wireless communications and networks. The overview first covers definitions of propagation environments as they determine most relevant propagation mechanisms to con
This paper presents the hardware/software generation backend of a code generation framework. The backend aims at synthesizing complete systems based on RISC-V cores with accelerators from a single-language description. The framework takes the dataflow description of an algorithm as input and generates a combination of hardware (in Chisel) and software (in C) that interacts with the hardware. The h
With the purpose of examining biased updates in variance-reduced stochastic gradient methods, we introduce SVAG, a SAG/SAGA-like method with adjustable bias. SVAG is analyzed in a cocoercive root-finding setting, a setting which yields the same results as in the usual smooth convex optimization setting for the ordinary proximal-gradient method. We show that the same is not true for SVAG when biase
In recent decades, the Barents Sea has warmed more than twice as fast as the rest of the Arctic in winter, but the exact causes behind this amplified warming remain unclear. In this study, we quantify the wintertime Barents Sea warming (BSW, for near-surface air temperature) with an average linear trend of 1.74 °C decade-1 and an interdecadal change around 2003 based on a surface energy budget ana
An approach to resilient planning and control of autonomous vehicles in multi-vehicle traffic scenarios is proposed. The proposed method is based on model predictive control (MPC), where alternative predictions of the surrounding traffic are determined automatically such that they are intentionally adversarial to the ego vehicle. This provides robustness against the inherent uncertainty in traffic
The MeerKAT radio telescope consists of 64 Gregorian-offset antennas located in the Karoo in the Northern Cape in South Africa. The antenna system consists of multiple subsystems working collaboratively to form a cohesive instrument capable of operating in multiple modes for defined science cases. We focus on the channelizing subsystem (F-engine), the correlation subsystem (X-engine), and the beam
