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Background: Familial prostate cancer risk estimates are inflated by clinically insignificant low-risk cancer, diagnosed after prostate-specific antigen testing. We provide age-specific probabilities of non-low- and high-risk prostate cancer. Methods: Fifty-one thousand, eight hundred ninety-seven brothers of 32 807 men with prostate cancer were identified in Prostate Cancer data Base Sweden (PCBaS

Local blood flow was measured with 133Xe clearance technique in eight male distance runners, where one leg was cooled for 20 min by applying two "instant cold packs" on the quadriceps muscle. An initial cooling period after resting was followed by a second cooling period 10 min after running. Skin temperature was maximally reduced after 4.5 min of cooling, both at rest and after running, by 15 deg

The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic facto

Popular Abstract in Swedish Idag har patienter med blodcancer (leukemi) eller genetiskt betingade blodsjukdomar (sickelcellanemi etc.) begränsad tillgång till behandlingar som effektivt och riskfritt botar sjukdomstillståndet. Detta arbete inkluderar forskningsresultat ämnade att bidra till utveckling av konceptuellt nya behandlingsmetoder för olika typer av blodsjukdomar. Ett fungerande blodsysteThere is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. The indefinite expansion capacity of PSCs, combined with the possibility of creating these cells from patient-specific

Osteoarthritis (OA) of the knee can be defined as primary (non-traumatic) or secondary (post-traumatic). Both non-traumatic OA and post-traumatic OA have been described predominantly in the medial compartment of the knee. The objective of this study was to compare the location of structural radiographic changes in non-traumatic OA and post-traumatic OA. A non-traumatic cohort, consisting of 155 pa

Background Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial signal of efficacy in BRCA-deficient ovarian cancers have been reported. We therefore assessed the efficacy, safety, and tolerability of olaparib alone in women with BRCA1 or BRCA2 mutations and advanced breast cancer. M

INTRODUCTION: Children and adolescents are encouraged to maintain a habitually active lifestyle because of the known health benefits associated with regular physical activity, but there are some reports that a high level of activity may be associated with increased fracture risk. This prospective controlled exercise intervention study in pre-pubertal children evaluated if a school-based exercise i

Background No effective standard treatment exists for patients with radioiodine-refractory, advanced differentiated thyroid carcinoma. We aimed to assess efficacy and safety of vandetanib, a tyrosine kinase inhibitor of RET, VEGFR and EGFR signalling, in this setting. Methods In this randomised, double-blind, phase 2 trial, we enrolled adults (aged >= 18 years) with locally advanced or metastatic

Young people today are on the move as never ever, both physical, mentally and literally. They reason is the need to gain the knowledge and experience needed to increase their employability. The world is open as ever before and everyone has today the possibilities to learn everything from everywhere at any time.

Popular Abstract in Swedish Populärvetenskaplig sammanfattning på svenska Abort är ett av de vanligaste kriurgiska ingreppen i Sverige. 1989 var aborttalet för hela landet 21.5 per 1000 kvinnor i åldern 15-24 år. Storstäderna Stockholm, Göteborg och Malmö har i många år haft det högsta aborttalen, vilka var för dessa 1989 28.4, 27.0 respektive 27.8. De aktuella studierna omfattar de 1466 kvinnorIn Sweden between 32-38,000 women annually elect to terminate pregnancy by means of induced abortion, though their reasons are still not well understood. The purpose of these studies, carried out at the Department of Obstetrics and gynecology and of Community Medicine at University Hospital, Malmö, was to elucidate the incidence of induced abortion in an urban population, with special emphasis on

Det har skrivits mycket om Karen Blixen genom åren, både av danska, svenska och engelsktalande författare. Hennes liv och författarskap har fascinerat många, så även mig. I min uppsats kommer jag att ta fasta på några frågeställningar med anknytning till Den afrikanske farm. Ett syfte är att belysa genreproblematiken, och svårigheten att sätta in Den afrikanske farm i något av de vedertagna genre

OBJECTIVES: To evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. Secondary hypotheses were that temporal reductions in mortality would be seen an

Human complex-forming glycoprotein, heterogeneous in charge (protein HC) has previously been isolated from urine and immunochemically shown to be present in low and high molecular weight forms in blood plasma (Tejler, L., and Grubb, A. O. (1976) Biochim. Biophys. Acta 439, 82-94). In the present work, the major low and high molecular weight forms of the protein were isolated from plasma by immunos

BACKGROUND: Recent studies have reported that reduced-dose trimethoprim-sulfamethoxazole (TMP-SMX) may be effective in the treatment of Pneumocystis jirovecii pneumonia (PJP), but data are lacking for patients with hematologic malignancies.METHODS: This retrospective study included all adult hematologic patients with PJP between 2013 and 2017 at 6 Swedish university hospitals. Treatment with 7.5-1

IntroductionData regarding the impact of adenomyosis on the outcomes after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment are conflicting. Standardized diagnostic criteria are prerequisites for studying a potential association between adenomyosis and IVF/ICSI treatment outcomes. This study aims to examine the cumulative live birth rate (CLBR) after the first IVF/

Fat-soluble vitamin D is an essential bioactive compound important for human health. Insufficient vitamin D levels can result not only in bone disease but also in other disorders, such as cancer, metabolic disorders, and diseases related to poor immune function. The current methods commonly used for vitamin D analysis are often applied to determine the levels of the most abundant metabolite in pla

OBJECTIVES: To explore broadened entry criteria of the 2021 European Resuscitation Council/European Society of Intensive Care Medicine (ERC/ ESICM) algorithm for neuroprognostication including patients with ongoing sedation and Glasgow Coma Scale-Motor score (GCS-M) scores 4–5. DESIGN: Retrospective multicenter observational study. SETTING: Four ICUs, Skane, Sweden. PATIENTS: Postcardiac arrest pa