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Three-dimensional neuronal culture systems such as spheroids, organoids, and assembloids constitute a branch of neuronal tissue engineering that has improved our ability to model the human brain in the laboratory. However, the more elaborate the brain model, the more difficult it becomes to study functional properties such as electrical activity at the neuronal level, similar to the challenges of

http://nro.sagepub.com/ The Neuroscientist http://nro.sagepub.com/content/early/2013/07/22/1073858413497265 The online version of this article can be found at:   DOI: 10.1177/1073858413497265 published online 22 July 2013Neuroscientist Malin Åkerblom and Johan Jakobsson MicroRNAs as Neuronal Fate Determinants     Published by: http://www.sagepublications.com can be found at:The NeuroscientistAddit

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/akerblom.pdf - 2026-05-25

BACKGROUND AND PURPOSE: MR imaging has made it easier to distinguish among the different types of intracranial mass lesions. Nevertheless, it is sometimes impossible to base a diagnosis solely on clinical and neuroradiologic findings, and, in these cases, biopsy must be performed. The purpose of this study was to evaluate the hypothesis that proton MR spectroscopy is able to improve preoperative d

According to landscape theory proteins do not fold by localised pathways, but find their native conformation by a progressive organisation of an ensemble of partly folded structures down a folding funnel. Here, we use kinetics and protein engineering to investigate the shape of the free-energy profile for two-state folding, which is the macroscopic view of the funnel process for small and rapidly

To enter new markets is not easy. The most obvious challenge, at least judging from the majority of literature on internationalization, is to understand the new market thus taking a market(ing) perspective. External aspects of internationalization are often stressed, while internal aspects, focusing on why organizations fail, are less developed or examined. In order to better understand the intern

For the production of basic materials a deep decarbonization fundamentally requires the development of new process technologies. However, the climate policies currently adopted in G8 countries mainly reward incremental improvements and preserve industrial structures rather than induce innovation and preparations for a low-carbon transition. The current policy approach is motivated by fear of carbo

OBJECTIVES: Infantile hemangiomas (IHs) are common; some cases require timely referral and treatment to prevent complications. We developed and validated a reliable instrument for timely and adequate referral of patients with IH to experts by nonexpert primary physicians. METHODS: In this multicenter, cross-sectional, observational study, we used a 3-stage process: (1) development of the Infantile

Popular Abstract in Swedish Denna studie är ämnad åt att undersöka joniseringsprocessen i gaser, både teoretiskt och experimentellt. Arbetet är speciellt riktat mot att utöka förståelsen för detta fenomen i förbränningsrummet av en förbränningsmotor. Den intensiva joniseringsprocessen som uppstår till följd av den antändande gnistan har studerats såväl som den svagare joniseringsprocessen som är rThe processes that govern the formation, existence and consumption of ions in gases have been studied both experimentally and theoretically. The aim of the work is targeted at increasing the understanding of these phenomena in the working gases inside an engine. Both the cause and the application of ionized gases inside the cylinder of a spark ignited (SI) engine has been studied. The spark disch

In modern industrial settings with small batch sizes it should be easy to set up a robot system for a new task. Strategies exist, e.g. the use of skills, but when it comes to handling forces and torques, these systems often fall short. We introduce an approach that provides a combination of task-level planning with targeted learning of scenario-specific parameters for skill-based systems. We propo

Sammanfattning Markavvattning innebär att en åtgärd som genomförs permanent ändrar markens vattenförhållanden. Detta görs för att marken ska bli lämplig att använda genom att ta bort oönskat vatten genom dränering eller dikning. Det kan också vara genom skydd mot vatten vid invallning. Markavvattning ska uppfylla syftet att varaktigt öka en fastighets lämplighet för ett visst ändamål. Ett markavvDrainage units are measures that permanently modify the water conditions of the land. This is done through drainage or dikes to make the soil more suitable for use by removing unwanted water. Drainage units shall fulfill the purpose of permanently increasing the suitability of a property for a specific purpose. A joint drainage unit is a drainage unit commonly used by several properties. For execu

Det finns många olika utformningar av lyfthjälpmedel och hjälpmedel för att gå, så som patient lyftar och rullatorer, men det finns inte många lösningar som kan göra båda. Detta examensarbete är baserat på en person med fysisk funktionsnedsättning som har specifika behov för vilka det inte fanns någon anpassad lösning. Målet var att utveckla en produkt som kan lyfta användaren från sittandes till There exist many different designs of lifting aids and walking aids, but barely any solutions that can do both. This thesis is based on a person with mobility impairment with specific needs for which there were yet no adapted solution. The goal was to design a product that can lift the user from sitting to standing position and then be a walking aid by supporting the user by the armpits, all this

Background: Historically, the risk management activities in Gambro have been focused to ensure safety for patients and users of the company’s products where Regulatory and legal demands have driven the development. Lately, the need for a similar approach to assess and manage business risks has risen. When an earthquake hit the company’s facilities in northern Italy in 2012, the company did not hav

När man talar om framtiden finns det ett begrepp som dyker upp i nästan varje diskussion: "articiell intelligens". Vår fascination kring framtidens potentiellt självtänkande robotar speglas i hur mycket det diskuteras i alla yrkesgrupper just nu, oavsett om ämnet är koldioxidutsläpp, självkörande bilar eller automatiska inköpslistor. Men hur långt har egentligen maskininlärning kommit idThe task of Automated Essay Scoring (AES) has been active for more than half a century, starting with handcrafting statistical features used for linear regression, and currently being improved by the latest advancements in machine learning and natural language processing. Most current research uses some form of character or word embeddings to represent the essays rather than statistical features,

I november 2019 tillsattes en särskild utredare som fått i uppdrag att analysera om det finns ett behov och är lämpligt att införa ett så kallat kronvittnessystem. Med kronvittne avses en misstänkt som genom att medverka i utredningen av annans brottslighet går fri från straff eller får en mildare påföljd. Ett av de största argumenten mot ett kronvittnessystem är svårigheterna vid bevisvärderingenIn November 2019, a special investigator was given the assignment to analyze if there is a need to introduce a so called crown witness system in Sweden. A crown witness is a suspect that receives a reduced sentence for participating in the investigation or testifying of another´s criminal act. One of the biggest arguments against such a system is the difficulty to evaluate the credibility of a tes

This project started out as a test, and a request, an invitation to participate in a highly singular architectural project. Located in the western harbour of Malmö, the OHBOY! bike hotel belongs to an ambitious and ground-breaking approach at redefining the way we design cities and map- out our priorities, emphasizing mobility and making an active effort at minimizing our impact on the city’s tra

I december 2015 skrev den svenska regering under FN:s Agenda 2030 bestående av 17 hållbarhetsmål med tillhörande 169 delmål. Mål 12, delmål 3 lyder: “Till 2030, halvera det globala matsvinnet per person i butik- och konsumentledet, och minska matsvinnet längs hela livsmedelskedjan, även förlusterna efter skörd.” Att fullt ätbar mat slängs belyser alla tre aspekter av begreppet hållbarhet på ett efIn 2015 the Swedish government signed the UN Agenda 2030 comprising of 17 Sustainable Development Goals and a total of 169 sub targets. Goal 12 target 3 reads as follows: “By 2030, halve per capita global food waste at the retail and consumer levels and reduce food losses along production and supply chains, including post-harvest losses.” Wasting eatable food effectively highlights all three param

Brottet kontakt med barn i sexuellt syfte kallas även för grooming. Grooming kriminaliserades i Sverige år 2009 och i Storbritannien år 2004. Grooming är ett brott där förövaren, som är en vuxen person, kontaktar och lär känna målsäganden, som är ett barn, för att möjliggöra sexuella över-grepp. Förövaren genomför groomingprocessen för att bygga upp en relation till och vinna tillit hos barnet. DeThe felony, contact with a child in sexual purpose, is also called grooming. Grooming was criminalized in Sweden in 2009 and in Great Britain in 2004. Grooming is a felony where the perpetrator, who is an adult, get in touch with and get to know a child with the intention to sexually abuse the child. The perpetrator is using grooming to build a relation and gain trust with the child. It is rather

Den rådande marknaden har nått en punkt där teknisk innovation och tekniska egenskaper har blivit mindre viktiga konkurrensmedel, varför TechCo har insett vikten av tidig brukarinvolvering i innovationsprocessen. För att kunna dra fördel av brukarinvolvering så krävs det emellertid ett innovativt klimat och en effektiv FFE-process. Syftet med detta examensarbete är att undersöka hur pass förbereddAs the topical engineering industry has reached a point where technical innovation and technical features have become less important as means of competition, TechCo has realized the importance of user involvement in their early stages of development. However, in order to absorb this new input flow, certain prerequisites are needed namely an innovative climate and a proficient FFE. The purpose of t

This research is giving a descriptive view on reformation process of accounting education in Russia after collapse of the Soviet Union through the lens of transnational governance and institutional theory. The research was conducted using inductive approach and qualitative research design. The interviews were used as a main research tool supplemented with secondary source analysis. Five semi-struc