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Background Recent decades have witnessed tangible improvements in childhood cancer survival. However, the prognosis for children with congenital heart disease (CHD), the most prevalent birth defect, remains unclear. Due to improved survival of CHD and childhood cancer, evaluating outcomes within this intersection is important for clinical practice. We aimed to assess mortality post-cancer diagnosi

With the abundance of data and digital traces of human behavior that are currently available, and the accessible algorithmic analyses to analyze them, management scholars have the opportunity to expand their scope of theoretical discovery and tackle increasingly complex management. However, we need additional elaboration on how algorithmic analysis can augment humans inference making, and how to b

Background: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recr

Background-Treatment with renin-angiotensin system (RAS) inhibitors might restrain the structural/electrical remodeling associated with atrial fibrillation (AF). Limited evidence exists regarding the potential benefits of RAS inhibition post-acute myocardial infarction (AMI) in patients with AF. This study sought to assess the association between RAS inhibition and all-cause mortality and new-onse

Forested countries in the global south that have agreed to engage in REDD+, a policy mechanism for addressing climate change, are receiving support to improve laws, policies, systems and structures. As a mechanism initiated at the global level and seeking to use forests to address a global commons crisis (atmospheric carbon concentration), understanding how REDD+ translates into implementation at

Type of Study: This is a longitudinal, case-control clinical trial. Objectives: This study aims to track recovery time following a vocal loading task (VLT) imposing vocal fatigue and to explore if patients with functional dysphonia (FD) are worse affected by vocal loading, and if these patients take longer than others to recover. Methods: Fifty (n = 50) female participants in four vocal subgroups

This doctoral thesis uses a meta-critical method with an epistemological approach. The corpus consists of the doctoral theses presented in the United States about the novels of the Peruvian-Spanish writer and Nobel Prize winner in 2010 Mario Vargas Llosa, one of the most outstanding Spanish-speaking authors, with an extensive literary production. The study covers the 56 doctoral theses presented b

Purpose Many city logistics initiatives have failed to become economically sustainable. The purpose of this paper is to explain the impacts of cost, revenue and goods flow variables on the economic performance of a business model for city logistics. Design/methodology/approach A cost/benefit analysis, with data from transport providers and the municipality, on a six-month pilot implementation of a

PurposeEmpirical studies show that 96% of the city logistics projects failed to become permanent, mainly due to the lack of sustainable business models (Quak et al., 2014; Malhene et al., 2012). Accordingly, it was concluded that the need of business model specifically designed for city logistics is high (Benjelloun, 2010). However, researchers have yet to describe the components and their interre

Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-B) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Downregulation of TP r

This work is devoted to the analysis of the interaction of two coaxial jet with swirling flow using Large Eddy Simulation methodology to reproduce the case of Roback and Johnson. The eight - flat - vanes in the annular nozzle are the precursor of the swirling annular jet with high swirl number. An implicit LES model was used, this model uses mesh size as filter width so no sub-grid model is requir

The notion of societal safety and security has recently been raised to deal with a composite landscape of diverse threats and vulnerabilities. The concept of resilience has gained currency in recent years in many contexts as an alternative to prevalent failure-oriented safety approaches. In order to be meaningful in a societal safety/security context, the resilience concept must be translated to a

Wood components such as cellulose, lignin and hemicelluloses all have potential to be used in biobased value-added products. Once extracted from the wood these components have to be separated and purified from co-extracted compounds. Membrane filtration can be used to achieve this separation and is believed to play an important role in biorefineries.Fouling is the single greatest obstacle to the i

Background: Difficulty in following and understanding conversation in different daily life situations is a common complaint among persons with hearing loss. To the best of our knowledge, there is currently no published validated Norwegian questionnaire available that allows for a self-assessment of unaided communication ability in a population with hearing loss. Purpose: The aims of the present st

Business model experimentation for sustainability is an intentional and systematic approach to identify, test and learn about value creation strategies that could be adopted by a business in response to current unsustainable trajectories. For businesses such as large clothing retailers the need to alter course is acute as pressure builds from economic, environmental and social angles. The circular

The MIC wild-type (WT) distribution for Mycobacterium tuberculosis in BACTEC 960 MGIT is not defined, which may result in poor reproducibility for drug susceptibility testing (DST), as several DST methods with different breakpoints are in use. In a comparison between MGIT and Middlebrook 7H10 medium of seven first- and second-line drugs, including 133 MIC determinations of 15 WT isolates, we found

Intestinal-derived chemokines have a central role in orchestrating immune cell influx into the normal and inflamed intestine. Here, we identify the chemokine CCL6 as one of the most abundant chemokines constitutively expressed by both murine small intestinal and colonic epithelial cells. CCL6 protein localized to crypt epithelial cells, was detected in the gut lumen and reached high concentrations

The ultrafast carotenoid band shift upon excitation of nearby bacteriochlorophyll molecules was studied in three different light harvesting complexes from purple bacteria. The results were analyzed in terms of changes in local electric field of the carotenoids. Time dependent density functional theory calculations based on known and model structures led to good agreement with experimental results,