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The influential role of Wnt5a in tumor progression underscores the requirement for developing molecules that can target Wnt5a-mediated cellular responses. In the aggressive skin cancer, melanoma, elevated Wnt5a expression promotes cell motility and drives metastasis. Two approaches can be used to counteract these effects: inhibition of Wnt5a expression or direct blockade of Wnt5a signaling. We hav

A supramolecular complex composed of Ru(II) tris-bipyridine, tyrosine, and dipicolylamine was synthesized and characterized. This complex was attached to TiO2 nanocrystalline films via ester groups at the Ru(II) chromophore, and photoinduced multistep electron transfer was investigated by laser flash photolysis and electron paramagnetic resonance techniques. Following ultrafast electron injection

The lexical and typological trajectory of Indo-European gender evolution Gerd Carling, Marc Allassionère-Tang, Silvia Luraghi, Sunny Pydugadu, Olof Lundgren &Filip Larsson(Lund University, University of Lyon, Pavia University, Pavia University, Lund University & Lund University) Keywords: Indo-European, gender, typology, evolution, phylogeneticsIndo-European is a family with a relatively s

Background: Dialectical behavior therapy (DBT) is an evidence-based treatment for self-harm and emotion regulation difficulties. A modified version, DBT-Skills System (DBT-SS), has been developed in the USA for individuals with cognitive difficulties. The present study is a pilot study, testing the DBT-SS in a Swedish context.Methods: Six participants were treated with individual therapy and group

A formalism was recently introduced to instrument, monitor and control computer applications based on the rate of heartbeats they emit, thereby quantitatively signaling their progress toward goals. To date, the idea was however used essentially in an heuristic manner. This work first shows that a very simple dynamic heartbeat rate model can be devised, an that said model allows to address the corr

The global antimicrobial drug resistance crisis requires urgency in searching for more effective broad-spectrum antimicrobial drugs. Here, we present a complete circular genome sequence and a plasmid of an antimicrobial-producing isolate, Bacillus velezensis strain Sam8H1, from the Makgadikgadi saltpans in Botswana. Bioinformatic analyses revealed 12 putative secondary metabolite biosynthetic gene

The asymptotic behaviour of deterministic logit dynamics in heterogeneous routing games is analyzed. It is proved that in directed multigraphs with parallel routes, and in series composition of such multigraphs, the dynamics admits a globally asymptotically stable fixed point. Moreover, the unique fixed point of the dynamics approaches the set of Wardrop equilibria, as the noise vanishes. The resu

Urbanisation is proceeding at an alarming rate which forces wildlife to either retreat from urban areas or cope with novel stressors linked to human presence and activities. For example, urban stressors like anthropogenic noise, artificial light at night and chemical pollution can have severe impacts on the physiology of wildlife (and humans), in particular the immune system and antioxidant defenc

We present the results of a near-infrared (NIR) monitoring programme carried out between 1999 and 2005 to determine the variability properties of the 'Arecibo sample of OH/IR stars'. The sample consists of 385 IRAS-selected Asymptotic Giant Branch (AGB) candidates, for which their O-rich chemistry has been proven by the detection of 1612 MHz OH maser emission. The monitoring data were complemented

The Forum Romanum constituted the religious, political, economic and administrative centre of Rome for more than a millennium. During this time it went through several changes. It transformed from a liminal zone in the periphery of the Iron Age settlements into a communal space and sacred ground; later into an arena for political struggle and civic ambition; and finally into a showcase for Imperia

Terrorism comes in various forms, clear and sometimes ambiguous, by terrorist cells and sometimes by state players. Nerve agent poisoning represents one of the notorious applications of chemistry in the world. Nerve agents have historically instigated major casualties in various parts, heavily impacting lives of civilians by causing debilitating neurological and psychiatric injuries. Nerve agents

BACKGROUND: Orthopaedic surgeons aim for mechanical alignment when performing total knee arthroplasty (TKA) as malalignment is associated with loosening. Loosening may be predicted by migration as measured with radiostereometric analysis (RSA), but previous RSA studies on postoperative alignment have shown contradictory results and have been limited to cemented implants and small numbers of patien

The decreasing extent of the Arctic sea ice has opened up new areas in the High North for industrial and commercial activities. These areas contain large reserves of oil and gas, and the region is home to some of the world’s richest fishing grounds. The region is of key strategic importance, and maintaining a Norwegian presence in the Arctic areas is considered to be a national priority. A major r

This paper provides an exploratory analysis about the effect of transportation infrastructure on poverty reductions in Mexico between 1990 and 2010. Using the density of highways and unprecedented official estimations of poverty at municipality level, I show that this type of infrastructure lead to reductions in poverty. On average, for every additional kilometer (km) of highway (km/100km2) povert

Marine debris is a major threat to wildlife and human health. This study examines the socioeconomic vulnerability of informal housing as arguably one of the main drivers of the abundance of marine debris in the aftermath of a tropical cyclone. Using the Abaco Islands, Bahamas, as a case, the study applies the capabilities approach to assess the societal impact of Hurricane Dorian. Findings indicat

Under år 2015 antog regeringen en ändring av brottsbalken (BrB, 1962:700) som ger rätten en möjlighet att erkänna strafflindring i fall där den tilltalade medverkar till utredningen av sin egen brottslighet (29 kap. 5 a § 1 st. BrB). Fastän ändringen hade önskvärda syften, bland annat en ökad effektivitet, är rätten att inte belasta sig själv en generell och grundläggande rättighet som inte får glIn 2015, the Swedish government adopted an amendment of the Swedish Criminal Code (brottsbalken, 1962:700) which grants the court a possibility to reduce the penalty in cases where the defendant contributes to the investigation of their own crime (chapter 29 § 5 a 1). While the rationale behind the amendment lies upon desirable arguments such as efficiency, the privilege against self-incrimination

Conventional agrifood systems significantly contribute to environmental degradation. While Community Supported Agriculture initiatives (CSAs) may provide insights into alternative agrifood systems, few studies have investigated challenges to their engagement with prefigurative processes. Through a case study of nine CSAs in South-Holland, the Netherlands, this thesis explores the extent to which C

In 2017 the Swedish government issued an official report containing proposed changes to the compulsory care legislation to strengthen the child rights perspective and provide extended knowledge to the workers within psychiatry. The aim of this study was therefore to examine the reasoning regarding the proposed changes in the comment letters following the official report of the Swedish government: