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Blood levels of Mycobacterium tuberculosis (Mtb)antigen-triggered immune markers in people exposed to tuberculosis with regard to Mtb infection status and receipt of tuberculosis preventive therapy

Background: Interferon-γ release assays (IGRAs) for tuberculosis infection (TBI) cannot distinguish different stages of the TBI spectrum (including spontaneously cleared infection). We investigated patterns of Mtb-specific blood mediators in people with and without TBI during tuberculosis preventive therapy (TPT). Methods: Individuals with likelihood of recent Mtb exposure, aged 15–25 years, with

Stellar escapers from M67 can reach solar-like Galactic orbits

We investigate the possibility that the Sun could have been born in M67 by carrying out N-body simulations of M67-like clusters in a time-varying Galactic environment, and following the Galactic orbits of stars that escape from them. We find that model clusters that occupy similar orbits to M67 today can be divided up into three groups, which we call hot, depleted, and scattered clusters. Hot clus

Conflict-reducing innovations in development enable increased multicellular complexity

Obligately multicellular organisms, where cells can only reproduce as part of the group, have evolved multiple times across the tree of life. Obligate multicellularity has only evolved when clonal groups form by cell division, rather than by cells aggregating, as clonality prevents internal conflict. Yet obligately multicellular organisms still vary greatly in 'multicellular complexity' (the numbe

Processing of amazon catfish skins - Dourada (Brachyplathstoma sp.) and Piraíba (Brachyplatystoma sp.)

In this work, Piraíba and Dourada skin wastes were used for leather processing. They were initially stripped and characterized by their percentage composition. The results showed that pH, differential pH cipher [SLC13/ IUC 11/ BS 1309:9 - Determination of pH value and Difference Figure of an Aqueous Extract], chromium content and mechanical properties after chromium tanning were in accord with lea

Urban Lives: A Micro- Level Approach to Economic and Demographic Change in the Twentieth Century

This chapter introduces the research presented in the volume. It starts by highlighting the importance of an individual-level perspective to understand how long-term economic and societal changes connected with industrialization and post-industrialization have affected individuals and families during the twentieth century and into the twenty-first century as these changes pertain to social class,

Adverse events within 1 year after surgical and percutaneous closure of atrial septal defects in preterm children

Introduction: Atrial septal defect is the third most common CHD. A hemodynamically significant atrial septal defect causes volume overload of the right side of the heart. Preterm children may suffer from both pulmonary and cardiac comorbidities, including altered myocardial function. The aim of this study was to compare the rate of adverse events following atrial septal defect closure in preterm-

Automated multiplexed affinity-based enrichment of peptides for LC-MS/MS plasma proteomics

Plasma proteomics offers high potential for biomarker discovery, as plasma is collected through a minimally invasive procedure and constitutes the most complex human-derived proteome. However, the wide dynamic range poses a significant challenge. Here, we propose a semi-automated method based on the use of multiple single chain variable fragment antibodies, each enriching for peptides found in up

Perceived discrimination and refraining from seeking physician's care in Sweden : an intersectional analysis of individual heterogeneity and discriminatory accuracy (AIHDA)

BACKGROUND: Discrimination may further impede access to medical care for individuals in socially disadvantaged positions. Sociodemographic information and perceived discrimination intersect and define multiple contexts or strata that condition the risk of refraining from seeking physician's care. By applying analysis of individual heterogeneity and discriminatory accuracy (AIHDA) we aimed to impro

The Assessment of Higher-order Thinking Skills in Online EFL Courses : A Quantitative Content Analysis

Studies within second language learning indicate that higher-order thinking skills (HOTS) are important for the process of learning a new language. At the same time, previous literature indicates that assessment tasks in online courses often focus on lower-order thinking skills. Little is still known about if and how thinking skills are assessed in online EFL courses. Hence, the purpose of this st

Transcatheter aortic valve implantation (TAVI) prostheses in vitro - biofilm formation and antibiotic effects

BackgroundTranscatheter aortic valve implantation (TAVI) is a percutaneous catheter-based treatment of aortic stenosis as an alternative to open heart valve surgery. In cases of TAVI endocarditis, the treatment possibilities may be limited as surgical removal of the infected valve may be associated with a high risk in elderly, comorbid or frail patients. The propensity of bacteria to form a biofil

The cosmic journey of dust grains – from nucleation to planetary system

Dust is essential to the evolution of galaxies and drives the formation of planetary systems. The challenge of inferring the origin of different pre-solar dust grains from meteoritic samples motivates forward modelling to understand the contributions of low- and high-mass stars to dust in our Solar system. In this work we follow the evolution of dust with tracer particles within a hydrodynamical s

Some issues of accessibility in online social services: direct access versus signposting

Easy and low-threshold access is considered to be a major advantage of online services. In Sweden, social services in several municipalities strive to increase their accessibility by responding to anonymous users online. This paper raises the question about the nature of accessibility that the online social services entail. Two online platforms were studied: synchronous online chats and asynchrono

De avtalade och lagstadgade begränsningarna av arbetstagarnas frihet – om sekretessens påverkan både inom och utom anställningsförhållandet

Uppsatsen syftar till att klargöra rättsläget avseende tystnadsplikt och huruvida lojalitetsplikt och kritikträtt samspelar, samt hur sekretessbestämmelser inverkar i rättsfrågan. Med utgångspunkt i det arbetsrättsliga förhållandet mellan arbetsgivare och arbetstagare undersöks hur lojalitets- och tystnadsplikt samt kritikrätt påverkar arbetstagarens handlingsutrymme, vilket sätts i relation till The thesis aims to clarify the legal framework regarding confidentiality and whether the duty of loyalty and the right to criticise interact, as well as how secrecy provisions affect the legal issue. Based on the employment relationship between employer and employee, the study examines how the duty of loyalty and confidentiality, as well as the right to criticise, affect the employee’s scope of ac

Metaphrasis : A Byzantine Concept of Rewriting and Its Hagiographical Products

Metaphrasis: A Byzantine Concept of Rewriting and Its Hagiographical Products represents a first and authoritative discussion of rewriting in Byzantium. It brings together a rich variety of articles that treat the topic of hagiographical rewriting from various angles.The contributors discuss and comment on different kinds of texts in Greek and other languages, including Apophthegmata Patrum, Passi

Chondroblastoma and chondromyxoid fibroma

Chondroblastoma and chondromyxoid fibroma are benign but locally aggressive bone tumors. Chondroblastoma, a destructive lesion with a thin radiodense border, is usually seen in the epiphysis of long bones. Chondromyxoid fibroma presents as a bigger, lucent, loculated lesion with a sharp sclerotic margin in the metaphysis of long bones. Although uncommon, these tumors can be challenging to manage.

Remote Nanoscopy with Infrared Elastic Hyperspectral Lidar

Monitoring insects of different species to understand the factors affecting their diversity and decline is a major challenge. Laser remote sensing and spectroscopy offer promising novel solutions to this. Coherent scattering from thin wing membranes also known as wing interference patterns (WIPs) have recently been demonstrated to be species specific. The colors of WIPs arise due to unique fringy