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Plasma proteomics offers high potential for biomarker discovery, as plasma is collected through a minimally invasive procedure and constitutes the most complex human-derived proteome. However, the wide dynamic range poses a significant challenge. Here, we propose a semi-automated method based on the use of multiple single chain variable fragment antibodies, each enriching for peptides found in up

BACKGROUND: Discrimination may further impede access to medical care for individuals in socially disadvantaged positions. Sociodemographic information and perceived discrimination intersect and define multiple contexts or strata that condition the risk of refraining from seeking physician's care. By applying analysis of individual heterogeneity and discriminatory accuracy (AIHDA) we aimed to impro

The photolysis rates of HCHO, DCDO, CH3CHO, and CH 3CDO are studied by long-path FTIR spectroscopy in natural tropospheric conditions at the European Photoreactor Facility (EUPHORE) in Valencia, Spain. Average relative photolysis rates jHCHO/j DCDO = 3.15 ± 0.08 and jCH3CHO/jCH3CDO = 1.26 ± 0.03 are obtained from three days of experiments for each reaction in the period June 17 to July 7, 2006.

Uppsatsen syftar till att klargöra rättsläget avseende tystnadsplikt och huruvida lojalitetsplikt och kritikträtt samspelar, samt hur sekretessbestämmelser inverkar i rättsfrågan. Med utgångspunkt i det arbetsrättsliga förhållandet mellan arbetsgivare och arbetstagare undersöks hur lojalitets- och tystnadsplikt samt kritikrätt påverkar arbetstagarens handlingsutrymme, vilket sätts i relation till The thesis aims to clarify the legal framework regarding confidentiality and whether the duty of loyalty and the right to criticise interact, as well as how secrecy provisions affect the legal issue. Based on the employment relationship between employer and employee, the study examines how the duty of loyalty and confidentiality, as well as the right to criticise, affect the employee’s scope of ac

This paper examines firefighter exposure to emissions during actual firefighting in building scenarios. The focus is on actual exposure, not small-scale lab tests, to identify research gaps in light of the International Agency for Research on Cancer (IARC) classification of firefighting as an occupation with a heightened risk for certain types of cancer. The work is based on a systematic literatur

Bekämpningen av penningtvätt utgör ett centralt samhällsintresse inom Europeiska unionen och har gett upphov till ett omfattande regelverk som ställer långtgående krav på att verksamhetsutövare behandlar och lagrar personuppgifter. Samtidigt har skyddet för den personliga integriteten stärkts genom EU:s allmänna dataskyddsförordning (GDPR). Regelverken är inte direkt motstridiga, men förutsätter eThe fight against money laundering constitutes a central public interest within the European Union and has resulted in an extensive regulatory framework imposing far-reaching obligations on obliged entities to process and retain personal data. At the same time, the protection of personal privacy has been strengthened through the EU General Data Protection Regulation (GDPR). Although these regulato

With the advancement in autonomous driving technology, the shape of vehicle seats is expected to change. Against this backdrop, a study is required to verify whether or not the diversely-changing seat arrangements are appropriate from the emotional perspective of the driver. This study set the first-row passenger scat with an adjustable seatback, such as an upright position, a 15-degree rotation,

For many years, fascism in East Central and Southeastern Europe remained an overlooked aspect of the history of transnational and transatlantic fascism. This introduction provides a background on how this came to pass and why we should rethink this assumption. The introduction explains how the heterogeneity of East Central and Southeastern European fascism alters the general understanding of Europ

Dust is essential to the evolution of galaxies and drives the formation of planetary systems. The challenge of inferring the origin of different pre-solar dust grains from meteoritic samples motivates forward modelling to understand the contributions of low- and high-mass stars to dust in our Solar system. In this work we follow the evolution of dust with tracer particles within a hydrodynamical s

Easy and low-threshold access is considered to be a major advantage of online services. In Sweden, social services in several municipalities strive to increase their accessibility by responding to anonymous users online. This paper raises the question about the nature of accessibility that the online social services entail. Two online platforms were studied: synchronous online chats and asynchrono

The weighted oscillator strengths (gf) and lifetimes for S VIII presented in this work were obtained by a multiconfigurational Hartree-Fock relativistic approach. In this calculation, the electrostatic energy parameters were optimized by a least-squares procedure in order to improve the adjustment to experimental energy levels. The values for gf and lifetimes were then calculated on the basis of t

Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their r

ABR-215757 (5757) is a quinoline-3-carboxamide (Q-compound) currently in clinical development for systemic sclerosis. Q-compounds have shown efficacy in several different models of autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis. However, the mechanism of action is still poorly understood. In this thesis we have tried to find the mechanism

Context Adjuvant imatinib administered for 12 months after surgery has improved recurrence-free survival (RFS) of patients with operable gastrointestinal stromal tumor (GIST) compared with placebo. Objective To investigate the role of imatinib administration duration as adjuvant treatment of patients who have a high estimated risk for GIST recurrence after surgery. Design, Setting, and Patients Pa

The association of Helicobacter pylori with gastroduodenal diseases is well established. The mode of transmission of the organism is still unclear, although the faecal-oral route has been proposed. H. pylori has been detected in gastric antrum, dental plaques, faeces and water. In the light of these studies we attempted to detect H. pylori in antral biopsies, dental plaques, and stool specimens of