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A Proteomic Dissection of Breast Cancer - Via Cells and Organelles to Pathways

Popular Abstract in Swedish Bröstcancer är den mest frekventa cancerformen bland kvinnor, 1 av 8 drabbas någon gång under sin livstid av sjukdomen. Införandet av mammografi har gjort att cancern upptäcks tidigare och detta, tillsammans med effektivare behandlingsformer, har bidragit till att dödligheten i bröstcancer sjunkit de senaste decennierna. Antalet fall av bröstcancer ökar dock ständigt, fBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Breast tumours are extremely heterogeneous, and each patient’s disease has different causes, prognosis and appropriate treatments associated with it. To enable a more individualised therapy, there is a substantial need for better characterisation of tumours and a deeper understanding o

Subsets of Human Dendritic Cells and their Role in Allergy

The immune system has evolved to protect the human body against harmful invaders. At the same time, development of tolerance against self-derived and innocuous foreign antigens is of vital importance in order to avoid detrimental immune disorders. In allergic conditions, hypersensitivity is developed against harmless antigens, such as pollen. Dendritic cells (DCs) serve as a link between the innat

War Violence, Sexual War Violence and Victimhood in Reconciliation Narratives of Survivors from the War in Bosnia and Herzegovina

In this analysis of the retold experiences of 27 survivors of the war in northwestern Bosnia, the aim is to describe the informants’ portrayal of “war violence”, “sexual war violence”, “victimhood”, and “reconciliation” as a social phenomenon as well as analyzing the discursive patterns that contribute to constructing the category “victim” and “perpetrator”. The violence practice during the war is

The Assessment of Higher-order Thinking Skills in Online EFL Courses : A Quantitative Content Analysis

Studies within second language learning indicate that higher-order thinking skills (HOTS) are important for the process of learning a new language. At the same time, previous literature indicates that assessment tasks in online courses often focus on lower-order thinking skills. Little is still known about if and how thinking skills are assessed in online EFL courses. Hence, the purpose of this st

Transcatheter aortic valve implantation (TAVI) prostheses in vitro - biofilm formation and antibiotic effects

BackgroundTranscatheter aortic valve implantation (TAVI) is a percutaneous catheter-based treatment of aortic stenosis as an alternative to open heart valve surgery. In cases of TAVI endocarditis, the treatment possibilities may be limited as surgical removal of the infected valve may be associated with a high risk in elderly, comorbid or frail patients. The propensity of bacteria to form a biofil

Cluster Formation Induced by Local Dielectric Saturation in Restricted Primitive Model Electrolytes

Experiments using the Surface Force Apparatus (SFA) have found anomalously long-ranged charge–charge underscreening in concentrated salt solutions. Meanwhile, theory and simulations have suggested ion clustering to be a possible origin of this behavior. The popular Restricted Primitive Model of electrolyte solutions, in which the solvent is represented by a uniform relative dielectric constant, εr

Oesophageal fluoroscopy in adults-when and why?

Oesophageal fluoroscopy is a radiological procedure that uses dynamic recording of the swallowing process to evaluate morphology and function simultaneously, a characteristic not found in other clinical tests. It enables a comprehensive evaluation of the entire upper gastrointestinal tract, from the oropharynx to oesophagogastric bolus transport. The number of fluoroscopies of the oesophagus and t

Maternal and Infant Health: Understanding the Role of Institutions and Medical Innovations

This chapter examines the development of maternal and infant mortality and its connection to changes in medical and healthcare treatment of mothers and infants in the city of Landskrona, Sweden, and its rural hinterland between 1905 and 2015. The authors show that maternal mortality, stillbirth rates, and infant mortality declined strongly in this period. In parallel, hospitals began to admit more

“Always a potent object”? : The Shifting Role of the Bible in Margaret Atwood’s Novels

The Bible appears regularly in Margaret Atwood’s novels, from The Edible Woman in 1969 to The Testaments in 2019. Atwood’s characters do not tend to be religious, but like most people in the Western world, they encounter the Bible in schools, at funerals, in headlines, advertisements, and occasionally from religious people themselves. Atwood’s Bible is a Christian Bible, the references running fro

Civic duty, Stasi society or Petty revenge: citizen reporting on tax cheating neighbors in Sweden and Denmark

Both Sweden and Denmark have experienced an increase in the number of people informing the social and tax authorities that their neighbors are cheating on social benefits or earning illegal incomes through ‘black work’ (‘angiveri’ om social bedrageri eller sort arbejde). At the same time, many municipalities and the social and tax authorities have established hot lines or web portals where citizen