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BACKGROUND. Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients. METHODS. Parental LNCaP c
We investigate the location of the point of maximal horizontal velocity for steady periodic water waves with vorticity.
Popular Abstract in Swedish Akut faryngotonsillit orsakas till ca 40 % av betahaemolytiska grupp A streptokocker (GAS) och till ca 10% av andra bakterier. Ca 30% av fallen är virusutlösta och i ca 20% är genesen okänd. GAS är mycket virulenta humanpatogener som förutom svalg- och hudinfektioner även kan förorsaka livshotande tillstånd som ?streptococcal toxic shock syndrome? och nekrotiserande fasIn acute pharyngotonsillitis group A streptococci (GAS) is the etiological agent in 30-50% of cases. Phenoxymethylpenicillin (pcV) is the drug of choice in Sweden. However, the failure rate is as high as 5-25% and further pcV treatment is followed by still higher failure rates. The background of failures remains largely elusive. The aim of the studies was: 1 To investigate the short- and long-term
We outline here a simple method to prepare polymeric surfaces of controlled surface topography on the micrometer scale, via assembly and arrest of microgel particles, for use in a range of biological applications to modify cell adhesion and spreading. In previous work by other groups, it has transpired that topography on the nanoscale is unlikely to be useful for this purpose, as roughness on this
Regulatory T cells (Tregs) participate in the control of the immune response. In the human system, an IL-10-secreting, T regulatory type 1 cell (Tr1)-like subset of Tregs can be induced by concurrent cross-linking of the TCR and CD46 on naive CD4(+) T cells. Because many viral and bacterial pathogens, including the major human pathogen Streptococcus pyogenes, bind to CD46, we asked whether this ba
We have investigated the formation of vesicles in the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) with the average composition EO5PO68EO5 in water. Vesicles are formed when a solution of unimers is heated into a two-phase region where, at equilibrium, a concentrated lamellar phase coexists with a dilute solution of unimers. The vesicles were
Moraxella catarrhalis ubiquitous surface protein A2 (UspA2) mediates resistance to the bactericidal activity of normal human serum. In this study, an interaction between the complement fluid phase regulator of the classical pathway, C4b binding protein (C4BP), and M. catarrhalis mutants lacking UspA1 and/or UspA2 was analyzed by flow cytometry and a RIA. Two clinical isolates of M. catarrhalis exp
Lysozyme adsorption to charged surfaces was studied by Monte Carlo simulations at different protein concentrations, protein net charges, ionic strengths, and surface charge densities. The lysozyme was represented by a hard sphere with embedded positive and negative surface charges parametrically dependent on the solution pH. A short-range attractive protein-protein potential was included to repres
A combined quantum mechanical-statistical mechanical method has been used to study the behavior of the hydroxyl ion in water. The system is divided into three parts, a quantum core (the ion), 89 classical water molecules, and a dielectric continuum. The water molecules are represented using a polarizable potential. The first solvation shell consists of four water molecules, two linked by hydrogen
Infrared spectra from 25 to 4000 cm(-1) have been recorded of water (H2O, D2O and (H2O)-O-18) matrix isolated in neon, argon, and krypton matrices. Intermolecular absorption bands of different isotopologues of the water trimer and tetramer have been assigned from concentration dependencies and diffusion behavior, using the well-known mid-infrared trimer and tetramer absorption bands as measures of
The hydrophobic interaction between two methane molecules in salt-free and high salt-containing aqueous solutions and the structure in such solutions have been investigated using an atomistic model solved by Monte Carlo simulations. Monovalent salt representing NaCl and divalent salt with the same nonelectrostatic properties as the monovalent salt have been used to examine the influence of the val
Objective: To examine and compare the adult outcome in a representative sample of hospitalized adolescent-onset psychoses including occupational and social aspects. Method: A total of 81 patients with a first episode of early-onset psychosis (before age 19 years) presenting to the University Hospital of Lund, Sweden, between 1982 and 1993 were followed up an average of 10.5 years (range 5.1-18.2)
On St. Bridget's confessor and the editor-in-chief of her works
A mixed amphiphilic system composed of the anionic surfactant Aerosol OT (AOT), in water forming a lamellar phase, to which is added a neutral noninteracting polymer, poly(N,N-dimethylacrylamide), is studied experimentally by SAXS, H-2 NMR, and microscopy, in a range of surfactant and polymer compositions. Addition of the polymer produces a decrease in the lamellar spacing, the decrease by the pol
Numerous polymerase chain reaction (PCR)-based methods have been developed and used increasingly to screen vertebrate blood samples for the diagnosis of haemosporidian blood parasites (Sporozoa, Haemosporida), but a rigorous evaluation of the sensitivity of these methods for detecting mixed infections of different haemosporidian species belonging to the same and different genera and subgenera is l
The compaction and aggregation of DNA induced by cationic surfactants was studied by dynamic light scattering (DLS). Furthermore, the effect on surfactant-compacted DNA of the addition of nonionic amphiphiles and salt was studied. When using sufficiently low amounts of DNA and cetyltrimethylammonium bromide (CTAB), compacted DNA molecules could be monitored by the appearance of a band characterize
The article deals with how the Armenian genocide, perpetrated by the Young Turkish regime in the Ottoman Empire during the First World War, has been handled by Armenians, Turks and the international community from its pertetration to the present.
Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of aff
We studied the role of arachidonic acid metabolites, histamine, and 5-HT in airway responses to trimellitic anhydride (TMA) in actively sensitized guinea pigs. Sensitization was produced by two intradermal injections of free TMA (0.1 ml of 0.3% TMA in corn oil). After 21 to 28 days, guinea pigs were anesthetized and challenged with intratracheal instillation of 0.5% TMA conjugated to guinea pig se
