Filetype
Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat all nine human herpesviruses and animal herpesviruses. The novel MOA targets the pressurized genome state in a viral capsid, "turns off" capsid pre
To define the clinical presentation of aerococcal infective endocarditis (IE) and the prevalence of synergy between penicillin and gentamicin on aerococcal isolates.
The addition of amphiphiles grafted with polyethylene glycol units to constructs of DNA-amphiphiles is of most relevance for applications demanding colloidal stability. In this work, we study the self-assembly behavior of a true ternary mixture comprising (i) an electroneutral complex of DNA and a cationic surfactant (dodecyltrimethylammonium, DTA), (ii) water, and (iii) nonionic surfactant (dodec
In this review, I will present an overview of the development of the field of scatter hoarding studies. Scatter hoarding is a conspicuous behaviour and it has been observed by humans for a long time. Apart from an exceptional experimental study already published in 1720, it started with observational field studies of scatter hoarding birds in the 1940s. Driven by a general interest in birds, sever
The human host-defense peptide LL-37 not only displays antimicrobial activity but also immune modulating properties that trigger intracellular signaling events in host cells. Since the cytolytic activity of high LL-37 concentrations affects cell viability, the function of LL-37 requires tight regulation. Eukaryotic cells therefore benefit from protective measures to prevent harmful effects of LL-3
In this thesis I discuss about economical and political transition in countries that is consecutively being induced by influential external actors. Looking closer on the role of the EU as a dynamic transitional force, with the intention of examining to what extent the EU can pursuit its interest and modify the economical as well as the political structures of transition countries. With relations t
This chapter presents life cycle assessment (LCA) and its current and potential use as a tool of governance. LCA is considered as providing governance input in three different dimensions: (1) as results; (2) as a method; and (3) as a mindset. Life cycle approaches are increasingly informing policymaking and legislation, either as an abstract idea such as “the circular economy” or as calculation ru
The narrative of domestic fiction frequently depicts a woman’s search for domestic bliss, as a mother, wife, and homemaker. Shirley Jackson has often contested this narrative by portraying female characters who, through uncanny manifestations of repressed desires and fears, go against these norms. ‘The Deamon Lover’ (1949) and ‘The Tooth’ (1949) present two female protagonists, who are confronted
The paper gives a brief presentation of the cultural and institutional specificities of Sweden and how these cultural and institutional specificities impact the development of the Swedish social welfare system over periods of change, transition and strategic adjustment. The paper concludes by presenting a suggestion of a new view of the relationship between culture and social welfare systems, whic
Astaxanthin (AXT) is a reference model of xanthophyll carotenoids, which is used in medicine and food industry, and has potential applications in nanotechnology. Because of its importance, there is a great interest in understanding its molecular properties and aggregation mechanism in water and mixed solvents. In this paper, we report a novel model of AXT for molecular dynamics simulation. The mod
Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NOx) among PE cases and normotensive controls influence DNA methylation
Background and purpose — There is an ongoing debate regarding the appropriate level of constraint in primary TKA. To provide increased stability and better kinematics, more resembling a natural knee, a medial congruent (MC) tibial insert has been introduced. To investigate potential impact on implant migration, we evaluated the cemented Persona TKA, randomizing between MC and cruciate-retaining (C
In order to develop new environmental policies, it is important first to evaluate those that have already been used. However, this intuitively simple idea is difficult to apply in practice, no more so than in the complex governance context of the EU. Attributing impacts to specific policies is challenging, and making evaluations useful for political decision making is even more demanding. Five app
Austrian artist and director of ZKM Center for Art and Media in Karlsruhe, Germany, Peter Weibel (Odessa, 1944), curates a book/catalogue of the mythical exhibition Sound Art, Sound as Medium of Art, that took place between March 2012 and February 2013 in Karlsruhe, with nearly one thousand images of sound art pieces. Along with a very detailed historical trace of sound as a form of art, the book
This study examines the differences and similarities in the news media’s portrayal of political topics related to artificial intelligence in the United States and Sweden. AI is increasingly politicized but is poorly understood from a political science perspective. By examining these two innovative and prosperous countries’ media landscapes, it aims to further our understanding of the cross-nationa
