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Clinical trials of pharmaceuticals have been running in Russia for more than ten years and while it is an attractive location for research, it remains a largely untapped resource as researchers look to expand patient recruitment outside the Western world. While academic sites like Moscow, St Petersburg and Novosibirsk have all gained experience in clinical trials, smaller hospitals in peripheral

Background: Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease over time. This study represents a novel approach to detect an altered activity of the disease process detected as increasing serum-COMP levels over a short time and whether this

Appropriate regulation of hematopoietic stem cell (HSC) numbers and function is a requisite for life-long blood cell replenishment. Knowledge of factors that regulate HSC activity is derived largely from murine model systems, with serial transplantation often considered a "gold standard" to assess longevity and self-renewal of HSCs. In the literature, we noted inconsistencies in how serial transpl

Popular Abstract in Swedish Sjukdomsuppfattningar. Värderingar och attityder hos patienter och medicine studerande. Utvecklingen av den biomedicinska kunskapen och de demografiska förändringarna under 1900-talet har inneburit en ökning av såväl behov av som efterfrågan på hälso- och sjukvård. Illabefinnande utan påvisbara sjukdomstecken och rädsla för sjukdom ligger ofta bakom vårdsökande. OfficieDuring the 20th century, the development of biomedical knowledge and the demographical changes have increased the needs and demands for health care in industrialised countries. Illness without evidence of disease and fear of disease are often the reasons for seeking medical care. Primary care is the official foundation of the Swedish health care system but priorities are vague and frequently chang

Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M

Background: Understanding the relationship between serum ferritin levels and cardiovascular outcomes in type 2 diabetes is crucial for improving risk stratification and guiding therapeutic interventions aimed at preventing major adverse cardiovascular events (MACE). This study aimed to identify distinct clusters of individuals with type 2 diabetes who have varying risks of MACE using a data-driven

The development of sustainable photosensitiser complexes based on Earth-abundant metallic elements is important for sustainable solar energy conversion and green synthesis through photocatalysis. We report the synthesis and characterisation of a new bis(tripodal) iron(III) N-heterocyclic carbene complex [Fe(PhB{impy}3)2]+ (PhB{impy}3 = phenyltris(imidazo-[1,5-a]-pyridinylidene)borate) featuring -e

Three new cobalt complexes of the general formula [Co(II)(L)(CH3CN)]2+, where L is one of three pentadentate nitrogen-donor ligands based on the N4Py framework, have been synthesized and characterized. The capacity of the three complexes to effect photocatalytic proton reduction has been examined. Their photocatalytic activities in the presence of [Ru(bpy)3]2+, acting as a photosensitizer, and asc

Popular Abstract in Swedish Vad är en familj, vilka kan bilda en familj och vem bestämmer det? Hur ser föreställningarna kring den ideala familjen ut? Och varför anses det viktigt att ha kännedom om sitt ursprung och att tillhöra en familj, en släkt eller en nation? I denna avhandling undersöks den svenska familjepolitiken kring internationella adoptioner och assisterad befruktning. UndersökningenThe purpose of this thesis is to study the norms and values surrounding the family and the nation-state in Swedish family policy as they appear in Official Government Reports (SOU) on international adoption and assisted reproductive technology (ART) between 1953 and 2007. I argue that the committees’ reports can be viewed as normative statements constituting a hegemonic state discourse. The method

BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women

Detta är introduktionskapitet till rapporten "DigiTrust: Tillit i det digitala. Tvärvetenskapliga perspektiv från ett forskningsprojekt", där forskargruppsledarna beskriver grunderna för projektet.

Pulsar binaries are important targets for ground-based and future space-borne gravitational-wave (GW) detectors. In order for improving detector design and assessing detector performances, it is a prerequisite to understand the astrophysics of GW sources such as the population size or merger rates. Here, we summarize recent results for Galactic merger rates of two known types of pulsar binaries: (

Objective: Transitions in the spectrum of valvular heart diseases (VHDs) in developed countries over the 20th century have been reported from clinical case series, but large, contemporary population-based studies are lacking.Methods: We used nationwide registers to identify all patients with a first diagnosis of VHD at Swedish hospitals between 2003 and 2010. Age-stratified and sex-stratified inci