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Biomolecular and pharmaceutical downstream processing is dominated by chromatographic separation, which is associated with high product quality, low capacity and high costs. The separation can be optimized to minimize the costs while achieving a high purity. This paper presents an experimental validation of a discretized multi-level elution (DiME) trajectory, implemented on commercially available
Purpose The aim of this study was to evaluate the long-term effect of 2 years of adjuvant tamoxifen compared with no systemic treatment (control) in premenopausal patients with breast cancer over different time periods through long-term (> 25 years) follow-up. Patients and Methods Premenopausal patients with primary breast cancer (N = 564) were randomly assigned to 2 years of tamoxifen (n = 276) o
In the Industry 4.0 era, time-sensitive and missioncritical control applications still have a long way to go, from being tied down and co-located with the systems they control, to taking full advantage of the cloud. Conservatively keeping applications local will deprive these complex applications of abundantcompute capacity, wider system integration, and the potential for collaborative control eff
Context. Several new multi-object spectrographs are currently planned or under construction that are capable of observing thousands of Galactic and extragalactic objects simultaneously. Aims. In this paper we present a probabilistic fibre-to-target assignment algorithm that takes spectrograph targeting constraints into account and is capable of dealing with multiple concurrent surveys. We present
The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability coefficients. In this pape
In massive multiple-input multiple-output (MIMO) systems, the large size of channel state information (CSI) matrix significantly increases the computational complexity of uplink detection and size of required memory to store the channel data. To address these challenges, we propose to perform detection in the angular domain, where the channel information can be presented in a more condensed way. T
Background: Coagulation activation is a hallmark of cancer, and anticoagulants have shown tumour-inhibiting properties. However, recent trials have failed to demonstrate improved survival with low-molecular-weight heparin (LMWH) in cancer populations. This has raised the question of suboptimal adherence as a possible explanation for the lack of benefit. Still, there is no standardised method to di
The interaction of oppositely charged lock- and key-colloids is investigated using computer simulations. We show that indented spheres, i.e., lock-particles, can be specifically assembled with spherical key-particles using solely electrostatic interactions in addition to a hard overlap potential. An analytic description of the entropic and energetic contributions is derived and supported by simula
Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants
Conventionally, radiofrequency (RF) coils used for magnetic resonance imaging (MRI) are electrically small and designed for nearfield operation. Therefore, existing antenna design techniques are mostly irrelevant for RF coils. However, the use of higher frequencies in ultrahigh field (UHF) MRI allows for antenna design techniques to be adapted to RF coil designs. This study proposes the use of par
Resistance to systemic therapy is a major problem in metastatic breast cancer (MBC) that can be explained by initial tumor heterogeneity as well as by evolutionary changes during therapy and tumor progression. Circulating tumor cells (CTCs) detected in a liquid biopsy can be sampled and characterized repeatedly during therapy in order to monitor treatment response and disease progression. Our aim
Small independent (indie) game startups face fierce competition when developing games with limited time, budget, and resources. Continuously testing and experimenting with new ideas, features, and content is essential to validate and guide development toward a viable and successful game. Such continuous experimentation (CE) requires access to users and user data, which is often very limited in the
Realistic representation of atmospheric aerosol size distribution dynamics in large-scale climate models is important for developing accurate descriptions of aerosol-cloud interactions. Despite the dynamic nature of the distributions, which have large seasonal and diurnal changes, model evaluations often focus on the annual median size distribution. Using more comprehensive monthly and diurnal mod
The Hunga Tonga eruption on 15 January 2022 (HT-22) induced vigorous volcano–sea interaction. Here we study the stratospheric aerosol and water vapor resulting from the eruption using satellite-based instruments: the CALIOP lidar and the Microwave Limb Sounder (MLS). We investigate the stratospheric relative humidity following the record-breaking water vapor injections from the HT-22 eruption and
The topic of this thesis is how to infer geometric information using sound data. Achieving this requires solving several subproblems. First, signal processing of the recorded sound is needed to compute measurements of primitive geometric relations. Secondly, robust estimation is needed to go from primitive geometric measurements to more useful higher-level information such as the locations of micr
Ensuring functional safety is crucial for the deployment of autonomous systems in real-life dynamic environments, as they must operate reliably and safely among humans. However, existing safety systems are designed with a closed-world assumption and can over-constrain the system by shutting down the robot at every safety violation, limiting the robot’s ability to complete its tasks. To address thi
Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short. Explaining the extensive genetic variation of fitness-related traits is thus a longstanding puzzle in evolutionary
Hand-eye calibration is a common problem in the field of collaborative robotics, involving the determination of the transformation matrix between the visual sensor and the robot flange to enable vision-based robotic tasks. However, this process typically requires multiple movements of the robot arm and an external calibration object, making it both time-consuming and inconvenient, especially in sc
