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OBJECTIVE: This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with aortic aneurysm (AA), peripheral artery disease (PAD) and arterial thrombosis and embolisation (ATE) in locations other than the heart and brain.METHODS: Nationwide Swedish family study. Data from the Swedish Multi-Generation Register for subjects aged 0-78 years old, coveri
Background: Thiopentone elimination has been described using Michaelis-Menten pharmacokinetics in adults after prolonged infusion or overdose, but there are few reports of elimination in neonates. Methods: Time-concentration profiles for neonates (n=37) given single-dose thiopentone were examined using both first-order (constant clearance) and mixed-order (Michaelis-Menten) elimination processes u
Background: There are few large register-based studies on people with intellectual disabilities (ID) that compare outcomes with the general population. Methods: All people in Skåne, the southernmost part of Sweden the 1st of January 2014 was included. Data concerning demographics/vital events, healthcare utilization and service and support for people with ID or autism spectrum disorder (ASD) was c
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids in Severe Antineutrophil Cytoplasmic Antibody-Associated Vasculitis) (NCT00987389) trial was the largest in AAV and the first to enroll participants with DAH requiring mechanical ventilation. Objectives
Background: Hip and groin problems are common in ice hockey but studies on professional female players are sparse. The available literature describes hip and groin problems by reporting incidence of time-loss injuries and may thereby underestimate the scope of these problems, which are often due to overuse and may not lead to absence from ice hockey participation.Purpose: The purpose of this study
Background: The pathological response to preoperative chemotherapy of colorectal liver metastases (CRLMs) is predictive of long-term prognosis after liver resection. Accurate preoperative assessment of chemotherapy response could enable treatment optimization. Purpose: To investigate whether changes in lesion-apparent diffusion coefficient (ADC) measured with diffusion-weighted magnetic resonance
Background and purpose — Obesity has been associated with inferior outcomes after laminectomy due to central lumbar spinal stenosis (CLSS); we evaluated whether this occurs in surgery on national bases. Patients and methods — We retrieved pre-and 1-year postoperative data from the National Swedish Quality Registry for Spine Surgery regarding patients aged ≥ 50 with laminectomy due to CLSS in 2005–
In the spring of 2018 a study by Stefan Sellbjer at Linnaeus University showed on one hand that several professors did not believe they could meet the school's knowledge requirements in their own subjects. Parents, on the other hand, thought that the knowledge requirements were so abstract and complex that they could no longer question their children about the homework. The purpose of this study i
BackgroundHospitalization indicates the presence of severe disease and constitutes a leading cost in health care. We aimed to prospectively assess if prevalent diabetes mellitus contributes to excess all-cause and cause-specific hospital admissions and mortality at the population level.MethodsWe used a Swedish prospective population-based cohort, including 25,642 individuals of whom 4.2% had preva
This study examines how the housewife ideal is constructed and presented as a contemporary phenomenon on the social media platform TikTok. The aim is to analyze how this ideal is represented and categorized in digital content, and to explore the notions of femininity, work, and life choices that emerge from these representations. The study further investigates how these portrayals can be understoo
Background: Abiraterone acetate (AA) is an androgen biosynthesis inhibitor shown to prolong life in patients with castration-resistant prostate cancer (CRPC) already treated with chemotherapy. AA treatment results in dramatic declines in prostate-specific antigen (PSA) in some patients and no declines in others, suggesting the presence of molecular determinants of sensitivity in tumors. Objective:
BACKGROUND: Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC).METHODS: Patient cohorts from two different HIPEC-centers underwent cytoreductive surgery and HIPEC with Oxaliplatin (39 patients) and MMC (56 patients), respectively. They were compared for toxicity and survival data. The ext
Background: Some endocrine disrupting chemicals (EDC), are “obesogens” and have been associated with overweight and obesity in children. Daily exposure to different classes of EDCs demands for research with mixtures approach. Objectives: This study evaluates the association, considering sex-specific effects, between prenatal exposure to EDC mixture and children's body fat at seven years of age. Me
Background: A substantial proportion of individuals with COPD have never smoked, and it is implied to be more common than previously anticipated but poorly studied. Aim: To describe the process of recruitment of never-smokers with COPD from a population-based cohort (n = 30 154). Methods: We recruited never-smokers with COPD, aged 50–75 years, from six University Hospitals, based on: 1) post bronc
Questions about the existence and temporality of intention in jazz improvisation are investigated based on phenomenological interviews with 48 expert jazz improvisers: Do improvisers intend that which they will play, and, if so, are their conception and execution of a musical idea coincident, or are they separated in time? The findings on improvisatory cognition are summarized and discussed by mea
Objectives Exposure to aluminium compounds, such as fluorides in gaseous and particulate form, places people who work in potrooms at risk for respiratory symptoms. Workers in potrooms, however, also are exposed to a number of other air contaminants. In this study, we present the first report of a dose-response relationship after exposure to potassium aluminium tetrafluoride (KAlF4) and the influen
Aims: To study mortality rates among patients with diabetes and concomitant atrial fibrillation (AF), prescribed different cardiovascular drugs in primary health care. Methods: Study population consisted of men (n = 1319) and women (n = 1094) aged = >= 45 years from a database including 75 primary care centres in Sweden. Cox regression analysis, with hazard ratios (HRs), 95% confidence interval (9
