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Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation of ERG in leukaemic cells remains poorly understood. In order to discover transcriptional regulators of ERG, we employed a quantita

Cell therapy raises hopes high for better treatment of brain disorders. However, the majority of transplanted cells often die soon after transplantation, and those that survive initially continue to die in the subacute phase, diminishing the impact of transplantations. In this study, we genetically modified transplanted human neural stem cells (hNSCs), from 2 distant embryonic stem cell lines (H9

Two Burmese eclipse calculations, one lunar and one solar, are analysed using examples from a Burmese manuscript. The fundamental parameters are with some important exceptions the same as in the Suryasiddhanta, but the handling of, for instance, parallax in the solar eclipse is different and much simplified. Specific to Burma are also the shadow calculations.

Aims: The aim of this study was to evaluate the prevalence of triple antithrombotic therapy (TT) (warfarin, aspirin and clopidogrel) in patients following an acute coronary syndrome (ACS), the bleeding risk compared to double antiplatelet therapy (DAPT) (aspirin and clopidogrel) and evaluate the accuracy of the HAS-BLED risk score in predicting serious bleeding events in TT patients. Methods and r

Summary: This study aimed to investigate if high levels of blood cadmium at baseline were associated with increased fracture risk during follow-up in middle-aged women. No increased fracture risk was observed during follow-up, but women with higher levels of cadmium had an increased overall mortality. Introduction: Exposure to high levels of cadmium has been associated with an increased fracture r

Objective To explore the clinical and neuroendocrine characteristics of syndromes of orthostatic intolerance and syncope in young adults. Methods Two hundred and thirty-six patients aged 18-40 years with orthostatic intolerance and/or syncope were examined by head-up tilt test (HUT). Plasma levels of epinephrine, norepinephrine, renin, C-terminal-pro-arginine-vasopressin (CT-proAVP), C-terminal-en

Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFRcystatin C and eGFRcreatinine plays a piv

Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her

Action-detected two-dimensional electronic spectroscopy (A-2DES) provides valuable insights into ultrafast dynamics within functional materials and devices by measuring incoherent signals like photocurrent. This work details the implementation and optimization of a pulse-shaper-based A-2DES setup, focusing on methodological strategies crucial for acquiring high-fidelity data. We present a comprehe

In this work, we derive the relationship between the states of strain and stress in pseudomorphic epitaxial layers on a substrate with differing equilibrium lattice parameters under symmetry-conserving conditions for the case of monoclinic crystal symmetry. We compare surface vectors across the template-epitaxial layer interface and impose conditions of a stress-free epitaxial layer. As a result,

Interfacial structures on the nanoscale are crucial for a wide field of applications ranging from biological membranes in life sciences through organic solar cells and industrial coatings in soft matter to hard matter structures. The latter include thin film coatings and materials such as magnetic nanoparticles and topological structures like magnetic skyrmions. Advancing such application rests on

A major challenge hampering the industrial and biological exploitation of lipases is the self-limiting effect of the lipolytic reaction. Defying sustained attention throughout history, the influence of lipase catalysed lipolysis on the internal structure of thin triglyceride films has proved elusive. An in-depth understanding of the lipolysis process at the triglycerides/aqueous interface will ass

Inverted perovskite solar cells (IPSCs) have emerged as promising photovoltaic technologies due to excellent photoelectric properties and solution processing advantages. However, the traditional preparation process based on inert atmosphere annealing of perovskite films faces key challenges, including high energy consumption, strict crystallization control, and the presence of stresses. The study

Passivity arises from spontaneous formation of a thin protective passive film (oxide/hydroxide layer) on the metal surface, and the stability of passive film is of great importance for corrosion resistance. This study investigates the formation, stability, and transpassive dissolution of passive films on two Ni-based alloys, Alloy 625 and Alloy 59, in acidified NaCl solution, by combining in situ

Background Sweden’s National Strategy for Sexual and Reproductive Health and Rights (SRHR) emphasises equitable access to contraception and abortion services. Despite this, immigrant women in Sweden experience lower contraceptive use and higher rates of unintended pregnancies and abortions compared with native-born women. Midwives, as primary providers of contraceptive counselling and prescribing,

BACKGROUND: Iron deficiency is the most common micronutrient deficiency worldwide, negatively affecting quality of life and health. Young women are at particularly high risk due to increased iron demands during growth, menstrual blood losses, and dietary habits. There are no official guidelines recommending screening for iron deficiency in healthy young women. This study aimed to develop a screeni

BACKGROUND AND AIMS: Guideline-directed medical therapy (GDMT) for heart failure (HF) is underutilized in primary care, particularly among older adults with chronic stable HF. This prospective quality improvement study, Heart Failure in Southern Sweden (HISS), evaluated the impact of a cross-disciplinary implementation project combining cardiology and primary care expertise to enhance GDMT adheren

Rupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression. We examined the role of Twist1, a transcription factor that drives endothelial-to-mesenchymal transition, in plaque progression by inducible deletion from endothelial cells in hypercholesterolemic mi

Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future Merkel cell carcinoma (MCC). Two large biobank cohorts (Southern Sweden Microbiolog