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BACKGROUND: A large proportion of skeletal muscle insulin resistance in type 2 diabetes (T2D) is caused by environmental factors.METHODS: By applying multiomics mRNA, microRNA (miRNA), and DNA methylation platforms in biopsies from 20 monozygotic twin pairs discordant for T2D, we aimed to delineate the epigenetic and transcriptional machinery underlying non-genetic muscle insulin resistance in T2D

BACKGROUND: Transportation noise has been linked with breast cancer, but existing literature is conflicting. One proposed mechanism is that transportation noise disrupts sleep and the circadian rhythm. We investigated the relationships between road traffic noise, DNA methylation in circadian rhythm genes, and breast cancer. We selected 610 female participants (318 breast cancer cases and 292 contr

Isolation and characterization of circulating tumor cells (CTCs) present a noninvasive alternative to monitor disease progression in individual patients. However, the heterogeneous lineage specificity of CTCs makes it difficult to isolate and identify possible CTCs by a liquid biopsy. Better label-free methods for the isolation of viable CTCs are needed. Our solution is a combined approach that is

OBJECTIVE: To explore the associations between daily time in sedentary behaviour (SED) and physical activity (PA) with perceived physical capacity, health-related quality of life (HRQoL) and fatigue in persons with post COVID-19 condition (PCC). An additional objective was to describe changes in SED and PA levels over three months.MATERIALS AND METHODS: Individuals with PCC self-reported on physic

It is well known that Lithium-ion batteries in thermal runaway can emit gases with high hydrogen concentrations which, in case of delayed ignition, can cause a gas explosion. Aerosol suppression agents are sometimes used to suppress fires and/or prevent ignition of released gases in such situations. The agent has been studied for suppression of fires (diffusion flames), but less is known about the

Rationale: Knowledge regarding the prevalence and shared and unique characteristics of the restrictive spirometric pattern (RSP) and preserved ratio impaired spirometry (PRISm) is lacking for a general population investigated with post-bronchodilator spirometry and computed tomography of the lungs. Objectives: To investigate shared and unique features for RSP and PRISm. Methods: In the Swedish CAr

In 2020, a case report described autologous transplantation of iPSC-derived dopamine (DA) neurons in a Parkinson's disease (PD) patient.1 The team now follows up with the pre-clinical safety and efficacy data of autologous iPSC-derived DA neurons, forming the basis for regulatory approval of a phase 1 clinical trial involving 8 patients.2

The co-occurrence of α-synuclein (αSyn) and Tau in synucleinopathies and tauopathies suggests a complex interplay between these proteins. Their cross-seeding enhances fibrillization, leading to the formation of diverse amyloid-specific structures enriched with β-sheets, which may influence their biological functions. However, existing tools cannot differentiate structural polymorphs directly in ce

Newts have large genomes harbouring many repeat elements. How these elements shape the genome and relate to newts’ unique regeneration ability remains unknown. We present here the chromosome-scale assembly of the 20.3Gb genome of the Iberian ribbed newt, Pleurodeles waltl, with a hitherto unprecedented contiguity and completeness among giant genomes. We provide evidence that intronic repeat elemen

This paper presents the first online, in-situ experimental evidence of the puffing behavior of aluminium (Al) atoms during the ignition of a micron-sized Al wire. As the protective alumina (Al2O3) layer ruptures, spatially resolved laser absorption measurements reveal the outward puffing of Al atoms from the molten Al wire core. These Al atoms then react with the surrounding oxidizers, leading to

The green transition relies on metals, requiring increased metal recovery from waste. However, exposure risks among metal recycling workers are poorly understood. We conducted a cross-sectional study to assess dust and metal exposure among 139 recycling workers from 13 Swedish metal recycling companies and 90 controls. We documented work practices through observations and questionnaires and assess

To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS). SCFS was operationalized using exi

Aim: To summarise key epidemiological and therapeutic research on osteoarthritis (OA) published between April 2024 and March 2025. Methods: A narrative review was conducted using the MEDLINE database, focusing on English-language studies involving human participants published between April 1, 2024 and March 31, 2025. Eligible studies included observational longitudinal studies, systematic reviews,

Objective Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are globally prevalent chronic diseases that affect millions of individuals in ageing populations. Hip and knee replacements are well established and effective treatments in patients suffering from end-stage OA. Understanding how T2DM influences the outcomes of these surgeries is important for optimising patient care and improving s

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases

The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in l

Artificial intelligence (AI) is set to transform the care of women with cancer. From early detection via digital phenotyping to diagnosis, treatment, and follow-up, innovative AI applications are rapidly emerging across the cancer care continuum. AI-assisted mammographic screening for breast cancer has been clinically translated, and AI-based contouring in radiotherapy is streamlining treatment pl

BACKGROUND: TF (transcription factor) Prdm16 (positive regulatory domain-containing protein 16) regulates hematopoietic and neuronal stem cell homeostasis, adipose differentiation, and cardiac development. Its role in the circulatory system extends beyond the heart, as Prdm16 loss in arterial endothelial cells (ECs) impairs arterial reperfusion of ischemic mouse limbs due to endothelial dysfunctio