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Performance and wear mechanisms of TiAlN-NbN coated cemented carbide in milling Ti6Al4V with different cooling and lubrication approaches

Titanium alloys are difficult-to-machine materials given their high strength, the high temperatures generated, and the naturally short contact length that combined result in rapid tool wear. Different machining strategies can be employed to cope with the low machinability. This study investigates the machining performance using different cooling and lubrication methods during down face milling of

Interaction and what follows : Electron beam effects in dynamic systems

Transmission electron microscopy (TEM) is an atomically resolved technique that allows for in depth analysis of the properties of materials by irradiating a thin sample with high energy electrons and detecting the signal imparted on, and generated by, the electron beam as it passes through. However, due to the strong interaction between electrons and matter, the sample will not remain unperturbed

Corynebacteria from the respiratory microbiota modulate inflammatory responses and associate with a reduced pneumococcal burden in the lungs

Background: Certain species from the normal respiratory tract microbiota have recently been proposed to positively influence human health. Corynebacterium propinquum and C. pseudodiphtheriticum (Corynebacteria) are two Gram-positive species that frequently colonize the upper respiratory tract and strongly associate with a reduced incidence of respiratory tract infections. The specific role of Cory

Time‐Resolved Photoemission Electron Microscopy on a ZnO Surface Using an Extreme Ultraviolet Attosecond Pulse Pair

Electrons photoemitted by extreme ultraviolet attosecond pulses derive spatially from the first few atomic surface layers and energetically from the valence band and highest atomic orbitals. As a result, it is possible to probe the emission dynamics from a narrow 2D region in the presence of optical fields, as well as obtain elemental specific information. However, combining this with spatially-re

Semidefinite programming relaxations for quantum correlations

Semidefinite programs are convex optimization problems involving a linear objective function and a domain of positive-semidefinite matrices. Over the past two decades, they have become an indispensable tool in quantum information science. Many otherwise intractable fundamental and applied problems can be successfully approached by means of relaxation to a semidefinite program. This methodology is

Nonprojective Bell-state measurements

The Bell-state measurement (BSM) is the projection of two qubits onto four orthogonal maximally entangled states. Here we first propose how to appropriately define more general BSMs, which have more than four possible outcomes, and then study whether they exist in quantum theory. We observe that nonprojective BSMs can be defined in a systematic way in terms of equiangular tight frames of maximally

On the wear mechanisms of uncoated and coated pcBN tools during turning of 17–4 PH martensitic stainless steel

Polycrystalline cubic boron nitride (pcBN) is a very promising tool material for turning martensitic stainless steels at high cutting speeds (vc > 200 m/min). The competitive advantage of pcBN over cemented carbide increases as the cutting speed is increased. Changing the speed might lead to a shift in the wear balance and hence the knowledge about tool wear below vc = 200 m/min might not be appli

EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP

Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on nove

Germline copy number variants and endometrial cancer risk

Known risk loci for endometrial cancer explain approximately one third of familial endometrial cancer. However, the association of germline copy number variants (CNVs) with endometrial cancer risk remains relatively unknown. We conducted a genome-wide analysis of rare CNVs overlapping gene regions in 4115 endometrial cancer cases and 17,818 controls to identify functionally relevant variants assoc

The effect of audit and feedback and implementation support on guideline adherence and patient outcomes in cardiac rehabilitation : a study protocol for an open-label cluster-randomized effectiveness-implementation hybrid trial

Background: Providing secondary prevention through structured and comprehensive cardiac rehabilitation programmes to patients after a myocardial infarction (MI) reduces mortality and morbidity and improves health-related quality of life. Cardiac rehabilitation has the highest recommendation in current guidelines. While treatment target attainment rates at Swedish cardiac rehabilitation centres is

Two-Thirds Maintain High Adherence to Digital Education and Exercise Therapy with Comparable Outcomes Across Adherence Clusters: A registry study including data from over 14,000 patients in Sweden

OBJECTIVE: To explore trajectories of 12-week adherence to a digital education and exercise therapy for knee and hip osteoarthritis (OA), associations with baseline characteristics, and trajectories of patient-reported outcomes measures (PROMs) up to 1-year follow-up.DESIGN: Retrospective cohort (registry) study.METHODS: Weekly data on adherence (i.e. the percentage of completed activities (exerci

Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample

OBJECTIVE: There is growing interest in how peers' genotypes may influence health (i.e., peer social genetic effects). The authors sought to clarify the nature of peer social genetic effects on risk for drug use disorder, alcohol use disorder (AUD), major depression, and anxiety disorder. METHOD: Cox models were used with data from a population-based Swedish cohort (N=655,327). Outcomes were drug

Population-based risk factors and urogenital comorbidities associated with genital herpes : A nationwide study of 4 million women

Objectives: To explore the population-based risk factors for genital herpes in women and examine whether genital herpes occurs at higher rates in women diagnosed with cervical neoplasia and common urogenital infections. Methods: An open cohort study consisting of 4,097,075 women ≥15 years of age in Sweden (2002-2018). The outcome was genital herpes diagnosis. The predictor variables were sociodemo

Evaluation of a self-monitoring protocol for assessing soot and polycyclic aromatic hydrocarbon exposure among chimney sweeps

Traditional methods for measuring chemical exposure have challenges in terms of obtaining sufficient data; therefore, improved methods for better assessing occupational exposure are needed. One possible approach to mitigate these challenges is to use self-monitoring methods such as sensors, diaries, or biomarkers. In the present study, a self-monitored method for measuring soot exposure, which inc

Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study

The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for historical, geographical, and secular trends, but until now not linked to health outcomes in the total population, e.g. for cardiovascular disease (CVD) or mortality during follow-up of birth cohorts. We used linkage analysis based on national registers in Swed

Stimuli-responsive drug delivery systems for inflammatory skin conditions

Inflammatory skin conditions highly influence the quality of life of the patients suffering from these disorders. Symptoms include red, itchy and painful skin lesions, which are visible to the rest of the world, causing stigmatization and a significantly lower mental health of the patients. Treatment options are often unsatisfactory, as they suffer from either low patient adherence or the risk of

Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study

Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul

Childhood neighborhoods and health in later Life : Hospital admissions in Sweden 1939-2015

We study the association between childhood neighborhood socioeconomic status (SES) (ages 1-15) and hospitalization with preventable-type disease in adulthood, using geocoded longitudinal microdata for a Swedish city (1939-1967) linked to national registers (1973-2015). Observing the full residential histories at the address level for the entire population, we construct dynamic and cumulative indiv