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The latticework duct plays an important role in turbine blade cooling for aircraft engines. The present numerical research provided information about the thermal performance in latticework ducts with different endwall shapes. Each latticework duct analyzed in this study had a crossing angle of 90° and 11 sub channels on both the two sides of the endwall. A numerical investigation was conducted at
Background: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. Objective: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on SARS-CoV-2 infection. Designs, settings, and participants: A randomized phase 2 clinical trial (COVIDENZA) enrolled 42 hospitalized COVID-19 patients before safety eva
The aim was to study the potential effect of neighborhood deprivation on incident and fatal coronary heart disease (CHD) in patients with bipolar disorder. This was a nationwide cohort study which included all adults aged 30 years or older with bipolar disorder (n = 61,114) in Sweden (1997–2017). The association between neighborhood deprivation and the outcomes was explored using Cox regression an
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared proteomic data from cone- and rod-rich retinae from human and mice and identified different expression profiles of cone- and rod-associated Müller cells that converg
BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes
The objective was to increase understanding of how knee-injured people make sense of using the Motor Imagery to Facilitate Sensorimotor Re-Learning (MOTIFS) training intervention. This model integrates structured psychological skills training into existing care-as-usual (CaU) rehabilitation protocols. To better understand patients' lived experiences of MOTIFS, it was necessary to understand those
For more than a century, the origin and evolution of the arthropod head and brain have eluded a unifying rationale reconciling divergent morphologies and phylogenetic relationships. Here, clarification is provided by the fossilized nervous system of the lower Cambrian lobopodian Cardiodictyon catenulum, which reveals an unsegmented head and brain comprising three cephalic domains, distinct from th
Two-dimensional (2D) cell culturing implies the cultivation of cells, isolated from an organism, to permit growth in 2D. Two-dimensional tissue culture surfaces are made of different kinds of glass and plastics with various degrees of hydrophilicity. The hydrophilicity is determined by the surface chemistry, which determines the adsorption of proteins required for cell attachment. Cellular physiol
Objectives We investigated gender differences in the association between mortality and general psychological distress (measured by 12-item General Health Questionnaire, GHQ-12), as an increased mortality risk has been shown in community studies, but gender differences are largely unknown. Setting We used data from a cross-sectional population-based public health survey conducted in 2008 in the Swe
To improve film cooling effectiveness of a gas turbine blade, a kind of plasma ac-tuator is introduced on the blade surface. The effect of three arrangements of plasma actuators on flow characteristics and film cooling performance is numer-ically investigated by a verified turbulence model. Results show that the coolant air under plasma is pulled down to the wall, and the near-wall air is sped up
Background: Little is known about how PFAS concentrations in human milk change over the course of lactation, although this is an important determinant of cumulative infant exposure from breastfeeding.Objective: To estimate changes in PFAS concentrations in human milk over the course of lactation in a population with a wide range of exposure from background-to high-exposed.Methods: We measured PFAS
Background: There are indications that early-life exposure to perfluoroalkyl substances (PFAS) can impact neurodevelopment, but results are inconclusive. The objective was to investigate if high early-life exposure to primarily perfluorohexanesulfonic acid (PFHxS) and perfluorooctanesulfonic acid (PFOS) increases the risk of developmental language disorder in children up to seven years of age.Meth
Background: Neuroma formation occurs after inappropriately or untreated nerve injuries. Patients surgically treated for neuroma were characterized and factors influencing outcome evaluated. Methods: In a retrospective observational study, data from medical records of patients surgically treated for neuroma in two Swedish regions were analyzed. Results: In 115 included patients (median age at surge
In this thesis, a microfluidics platform with high-speed imaging system was built to investigate gas-liquid flow in single microchannel and interfacial instability in porous media with microchannel network:The mass transfer of slug flow in the rectangular and square microchannels was experimentally studied by using water as liquid phase and CO2 as gas phase. Depending on flow rates, flow patterns
Gas-liquid displacement in porous media widely exists in many terrestrial/extraterrestrial subsurface resource extraction and utilization applications. The typical fingering displacement during gas invading has been well identified through extensive research efforts. Yet, the evolution of fingering structures after invading breakthrough is rarely reported. Herein, through a joint approach of exper
Recent evidence suggests that targeting S100A9 reduces pathological inflammation in abdominal sepsis. Herein, we investigated the role of S100A9 in neutrophil extracellular trap (NET) formation in septic lung damage. NETs were detected by electron microscopy in the lung and by confocal microscopy in vitro. Stimulation of isolated mouse bone marrow-derived neutrophils with S100A9 triggered formatio
Hypothesis: The self-assembly of long-tail surfactants results in the formation of nanoscale structures, e.g. worm-like micelles, with the ability to modify the rheology of the system. However, micelle formation, and thus the alteration of the rheology, is subject to the high Krafft temperature of saturated long-tail surfactants. Hexadecylmaltosides are sustainable surfactants that, in solution, f
Research on diel vertical migration (DVM) is generally conducted at the population level, whereas few studies have focused on how individual animals behaviorally respond to threats when also having access to foraging opportunities. We utilized a 3D tracking platform to record the swimming behavior of Daphnia magna exposed to ultraviolet radiation (UVR) in the presence or absence of a food patch. W
In recent years, the manipulation of Fano resonances in the time domain has unlocked deep insights into a broad spectrum of systems' coherent dynamics. Here, inelastic scattering of light with coherent acoustic phonons is harnessed to achieve complex Fano resonances. The sudden change of phonon momentum during reflection leads to a transition from anti-Stokes to Stokes light scattering, producing
Superconducting devices, based on the Cooper pairing of electrons, play an important role in existing and emergent technologies, ranging from radiation detectors1,2 to quantum computers3. Their performance is limited by spurious quasiparticle excitations formed from broken Cooper pairs4–12. Efforts to achieve ultra-low quasiparticle densities have reached time-averaged numbers of excitations on th
