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Surface proteins of pathogenic streptococci

Popular Abstract in Swedish Grupp B streptokocker (GBS; Streptococcus agalactiae) är den vanligaste orsaken till livs-hotande infektioner hos nyfödda barn. Enbart i USA orsakar GBS ~10 000 fall av meningit (hjärnhinneinflammation), pneumoni (lunginflammation) och sepsis (blodförgiftning) varje år. Infektionerna har hög dödlighet och en stor del av de barn som överlever infektionerna får bestående Streptococcus pyogenes (group A streptococcus) and the group B streptococcus (GBS) are two important human pathogens that cause different types of diseases and express different surface structures implicated in virulence. This thesis focuses on several surface proteins expressed by these pathogens, analyzing the biological function of these proteins and their ability to elicit protective immunity.

Statistics

Staff Calendar Link to RSS 13 May 2026 12:00 to 12:45 | Other The Financial Times FT50 journal list – a roundtable discussion 13 May 2026 12:15 to 12:45 | Other Lunchtime Piano Music #5 🎶 20 May 2026 12:15 to 12:45 | Other Lunchtime Piano Music #6 🎶 27 May 2026 12:15 to 12:45 | Other Lunchtime Piano Music #7 🎶 5 June 2026 08:45 to 14:00 | Event INNOVATION RESEARCH DAY at Lund University with CI

https://www.lusem.lu.se/internal/department-staff-pages/statistics - 2026-05-07

Lab-scale versus industrial-scale thermal runaway tests for lithium-ion battery cells

Lithium-ion battery safety is a topic of large importance, and testing is associated with large costs. Safety evaluation is therefore needed also at an early stage in cell design and development, in order to evaluate potential short-comings or to screen large platforms of materials and cells. Previous thermal runaway tests on lab-scale cells have, however, indicated differences in heat release and

Informell Vård SNAC2020 final (002)

– förändringar och samspel över tid 2001-2015 i SNAC projektet INFORMELL OCH FORMELL VÅRD HOS ÄLDRE PERSONER I ORDINÄRT BOENDE Anders Wimo, Ron Handels, Sölve Elmståhl, Cecilia Fagerström, Laura Fratiglioni, Ulrika Isaksson, Ole Larsen, Johan Sanmartin Berglund, Britt-Marie Sjölund, Anders Sköldunger, Maria Wahlberg Författarnas tack Den svenska nationella studien om åldrande, vård och omsorg – SN

https://www.geriatrik.lu.se/sites/geriatrik.lu.se/files/2021-06/Informell%20v%C3%A5rd%20SNAC2020_final%20(002).pdf - 2026-05-08

81 10262018 679 81 MP86 Kemppainen JAMA Ped 2017

Untitled Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity Kaisa M. Kemppainen, PhD; Kendra Vehik, PhD; Kristian F. Lynch, PhD; Helena Elding Larsson, MD, PhD; Ronald J. Canepa, BSc; Ville Simell, MSc; Sibylle Koletzko, MD, PhD; Edwin Liu, MD; Olli G. Simell, MD, PhD; Jorma Toppari, MD, PhD; Anette G. Ziegler, MD, PhD; Marian J. Rewers, MD, PhD; Åke

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/81%2010262018_679_81_MP86_Kemppainen_JAMA%20Ped_2017.pdf - 2026-05-08

Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q

Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i

Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Alkaline-extractable silicon from land to ocean: A challenge for biogenic silicon determination

The biogeochemical cycling of silicon (Si) along the land-to-ocean continuum is studied by a variety of research fields and for a variety of scientific reasons. However, there is an increasing need to refine the methodology and the underlying assumptions used to determine biogenic silica (BSi) concentrations. Recent evidence suggests that contributions of nonbiogenic sources of Si dissolving durin

Energy Storage & Conversion

Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r

https://www.energy.lth.se/research/energy-storage-conversion - 2026-05-07

Ulrika Liljeholm Rapport 0

376969_OMSL_Liljeholm rapport.indd Stöd till unga vuxna med psykisk ohälsa i deras karriärmål och övergång till arbete och studier ULRIKA LILJEHOLM INSTITUTIONEN FÖR HÄLSOVETENSKAPER | MEDICINSKA FAKULTETEN | LUNDS UNIVERSITET 1 Stöd till unga vuxna med psykisk ohälsa i deras karriärmål och övergång till arbete och studier Ulrika Liljeholm 2 Omslagsfoto: Ulrika Liljeholm Lunds universitet, Medicin

https://www.cepi.lu.se/sites/cepi.lu.se/files/2024-12/Ulrika%20Liljeholm%20rapport_0.pdf - 2026-05-08

Evolutionary and functional studies of protein H: a surface molecule of Streptococcus pyogenes

Popular Abstract in Swedish Protein H - ett bakteriellt ytprotein med förmåga att binda till olika proteiner hos människa Bakgrund I vårt dagliga liv omges vi av bakterier av många olika slag. Flertalet av dessa är normalt ofarliga och många utgör den så kallade normalfloran hos människa. En del bakterier kan under vissa förhållanden ge upphov till infektion och sjukdom, men för att åstadkomma d