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Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress

Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many diseases including Duchenne muscular dystrophy (DMD). Oxidative stress, heat shock proteins, endoplasmic reticulum (ER) stress and its response, i.e. unfolded protein response (UPR), play key roles in proteostasis but their involvement in t

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

Autoantibody-mediated diseases comprise a heterogeneous group of disorders in which the pathogenic potential of autoantibodies has been clearly demonstrated. In general, their treatment relies on the long-term use of systemic corticosteroids and other immunosuppressants that are associated with considerable adverse reactions. EndoS, an endoglycosidase derived from Streptococcus pyogenes, specifica

Methane fluxes from a small boreal lake measured with the eddy covariance method

Fluxes of methane, CH4, were measured with the eddy covariance (EC) method at a small boreal lake in Sweden. The mean CH4 flux during the growing season of 2013 was 20.1 nmol m−2 s−1 and the median flux was 16 nmol m−2 s−1 (corresponding to 1.7 mmol m−2 d−1 and 1.4 mmol m−2 d−1). Monthly mean values of CH4 flux measured with the EC method were compared with fluxes measured with floating chambers (