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Translocation-associated gene fusions are well recognized in acute myeloid leukemia. Other molecular genetic changes are less well known. The novel cDNA technology has opened the avenue to large-scale gene expression analysis. Our aim was to perform cDNA microarray analysis of acute myeloid leukemia (AML).
IgA1 mesangial deposition is the hallmark of IgA nephropathy and Henoch-Schönlein purpura, the onset of which often follows infections. Deposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but with no information concerning the influence of the IgA repertoire or the link between immune stimuli and IgA structure. We explored these issues in the α1KI mouse
We report a case of neuropathy induced by vibration and compression in the hand of a dental hygienist. Her hand function was improved considerably by repeated treatment during which EMLA(R) cream (EMLA(R) cream is a local anaesthetic agent containing lidocain 2.5% and priolocain 2.5%) was applied to the forearm to induce cutaneous anaesthesia.
Interannual variability in meteorological dryness and wetness in central Finland during the period 1959–2009 was analysed using Standardized Precipitation Index (SPI) on three timescales (annual, seasonal and monthly). For different time steps (12, 3 and 1 months) of SPI values (SPI12, SPI3 and SPI1), trends based on the Mann-Kendall non-parametric test and the most significant relationships with
Purpose. Examine the benefits and limitations of fine-needle aspiration cytology (FNA) used as the definitive diagnostic method before treatment.Method. Review of the 25 year experience at a multidisciplinary musculo-skeletal centre where FNA is the primary diagnostic approach to soft tissue sarcoma in the extremities and trunk wall and the experience of various experts in the field.Results. FNA h
We consider wireless systems with maximal-to the different transmit antennas are weighted replicas of ratio combining diversity at the base station, and hybrid selection/maximal ratio combining at the mobile station. We have recently proposed these systems, which provide high-quality data links, while keeping the complexity at the mobile station low. We analyze their performance in various realist
BACKGROUND: Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODOLOGY/PRINCIPAL FINDINGS: We sequenced the TLR4 promoter (4,3 kb) in Swedish blood donors. Since TLR4
Intervju med science fiction- och fantasyförfattaren Neil Gaiman.
To better understand the evolution of the viral envelope glycoproteins (Env) in HIV-1 infected individuals who progress to AIDS maintaining an exclusive CCR5-using (R5) virus population, we cloned and sequenced the env gene of longitudinally obtained primary isolates. A shift in the electrostatic potential towards an increased net positive charge was revealed in gp120 of end-stage viruses. Residue
A focus on constructing regional advantage requires an unpacking of what makes territorial agglomerations important for innovation and growth by disclosing and revealing the contingencies, particularities and specificities of the various contexts and environments where knowledge creation, innovation and entrepreneurship take place. In order to achieve more effective regional innovation policy, the
