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The clumpy nature of gas-rich galaxies at cosmic noon raises the question of universality of the scaling relations and average properties of the star-forming structures. Using controlled simulations of disk galaxies and varying only the gas fraction, we show that the influence of the galactic environments (large-scale turbulence, tides, and shear) contributes, together with the different regime of

Venetoclax, a specific inhibitor of the BCL2 protein, is administered for the treatment of acute lymphoblastic leukemia. However, despite being utilized in conjunction with chemotherapy, the drug exhibits instances of resistance. The exact mechanisms responsible for this resistance remain relatively obscure. Within the context of this investigation, the study aimed to explore the involvement of an

Context. The abundances of the α-elements are key for understanding the early chemical enrichment of the Galactic bulge. The elements of interest present lines in different wavelength regions, and some of them show lines only in part of the spectra. In the present work, the CNO trio, the a-elements Mg, Si, Ca, and Ti, and odd-Z Na and Al are examined as measured from optical and H-band lines. Aims

Purpose: This study aimed to assess the feasibility and short-term outcomes of different manufactured proximal and distal stent graft components during fenestrated endovascular aortic repair (FEVAR). Materials and methods: A multicenter retrospective review was conducted at 3 aortic centers, involving all consecutive patients who underwent FEVAR utilizing a customized Dacron-based tubular proximal

Scholars and practitioners are urgently highlighting the need to apply a relational approach to effectively address societal crises. At the same time, little is known about the associated challenges, and there is little advice regarding how to operationalize this approach in sustainability science. Against this background, this article explores how we can break out of our current paradigms and app

The short-time iterative adaptive approach is a spectral estimation alternative to the short-time Fourier transform for non-stationary vibration analysis. This technique offers a reduction in leakage effects and a higher resolution in exchange for a higher computational complexity. The short-time iterative adaptive approach can be summarized as a high-resolution data-dependent approach which has b

The initial Swedish discourse of transnational adoption as a win-win situation has changed over its more than 60-year-long history. This article aims to trace and present some themes in this history, with a particular focus on the public debate and the different narratives that representatives of the adoption triangle—the adoptees, the adoptive parents, and the biological parents—tell when dealing

Chemotherapy persists as the primary intervention for breast cancer, with chemoresistance posing the principal obstacle to successful treatment. Herein, we show that cartilage oligomeric matrix protein (COMP) expression leads to increased cancer cell survival and attenuated apoptosis under treatment with several chemotherapeutic drugs, anti-HER2 targeted treatment, and endocrine therapy in several

Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the risk for infections. We therefore envisioned a novel class of bispecific antibodies (bsAbs) which are

Aqueous liquid suspensions of high aspect ratio 2D clay nanosheets were investigated using small angle X-ray scattering (SAXS). The high aspect ratio of synthetic fluorohectorite clays allows for investigation of liquid crystalline orientational order for relatively large nanosheet spacings, in the range which can produce structural coloration, thus providing two handles for determining the nanosh

The diagnosis of lymphoma relies mainly on clinical examination and laboratory explorations. Among the latter, morphological and immunohistochemical analysis of a tissue biopsy are the cornerstones for proper identification and classification of the disease. In lymphoma with blood and/or bone marrow involvement, multiparameter flow cytometry is useful. This technique can also be applied to fresh c

Respiratory symptoms are ubiquitous and impair health-related quality of life in people with respiratory disease. This European Respiratory Society (ERS) task force aimed to provide recommendations for symptomatic treatment in people with serious respiratory illness. The ERS task force comprised 16 members, including representatives of people with serious respiratory illness and informal caregiver

Background/Aim: To select and stratify patients for optimal treatment plans is challenging. Identification of cancer-related biomarkers that serve as predictors for prognosis and treatment response is essential to better predict treatment outcome and find future targets for therapy. Previous data has suggested ARHGAP4 as a relevant biomarker in colorectal cancer (CRC). The purpose of this study wa

Quantum interference (QI) can strongly affect electric and thermoelectric properties of molecular junctions (MJs). So far, however, a limited number of experimental studies have explored the influence of QI on thermoelectric transport in MJs. To address this open point, we synthesized derivatives of meta-OPE3 with an electron-withdrawing nitro (-NO2) substituent or an electron-donating N,N-dimethy

Strategic critical minerals are essential materials that will dominate the energy transition and technological revolution. In the context of global climate change and industrial transformation, the geopolitical phenomenon of major powers competing for critical minerals has rapidly emerged, yet relevant research remains relatively limited. Therefore, this paper aims to summarize the geopolitical re

Purpose: Tricuspid valve flow velocities are challenging to measure with cardiovascular MR, as the rapidly moving valvular plane prohibits direct flow evaluation, but they are vitally important to diastolic function evaluation. We developed an automated valve-tracking 2D method for measuring flow through the dynamic tricuspid valve. Methods: Nine healthy subjects and 2 patients were imaged. The ap

This is an undeniable fact now that wireless systems pervade all aspects of our lives. These systems are evolving at a rapid clip, connecting more people and devices every single day that goes by. This growth is further fueled by the users’ insatiable appetite for more traffic, be it for online gaming, watching high-fidelity video, downloading huge files, live- streaming and many more uses. With t

This study explores affective encounters in retail marketplaces, illustrating how our researcher-consumer bodies experience and shape extended consumption spaces. Drawing on ethnographic observations in Sweden and the lenses of affect theory, it unveils how these spaces manifest affective disposition, disorientation, and distress, expanding our understanding of bodily-affective inclusion and exclu

This Discussion Paper aims to inform the Escazu Agreement’s (EA) Regional Action Plan on human rights defenders in environmental matters in Latin America and the Caribbean (Regional Action Plan).While most of the attention on defenders is placed in protecting them due to the risks that they face of being threatened or even assassinated, we argue that it is equally important to a) generate knowledg