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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with neuroinflammation and microglial dysregulation. Galectin-3 (gal-3), a β-galactoside-binding protein expressed in microglia, has been identified as an upstream regulator of neuroinflammatory responses and is increasingly recognized as a potential therapeutic target in AD. This Master’s thesis focuses on the design

Old-growth forests uniquely support biodiversity while serving as some of the planet's most important carbon stocks. The influence of tree and stand age on carbon flux dynamics remains debated—an urgent question as climate-driven disturbances may reshape forest age structures and in situ carbon storage. To clarify these relationships in Fagus sylvatica , systems, we examined a unique dataset of 3,

Time-interleaved ADCs are a key building block in mm-wave receivers, where the use of multi-GHz signal bandwidths requires high-performance wide-band data conversion. It is therefore necessary to explore the beamforming receiver system impact of different time-interleaved ADC parameters and limitations, such as number of interleaved channels, mismatches between channels, non-idealities of the subA

As immersive technologies expand in education, a gap persists between teachers’ familiarity with virtual reality (VR) tools and effective pedagogical use. This study designed, implemented, and evaluated a 60-h VR Trainer Training Program using Educational Design Research (EDR) and the Taba-Tyler curriculum model. Sixteen teachers participated in a needs analysis, followed by 42 in-service teachers

Syphilis has re-emerged as a public health threat during the 21st century, and updated knowledge of the epidemic and its drivers is needed to halt this worrying development. We present data on the incidence of syphilis in the south Swedish region Skåne from 2007 to 2022 to determine the burden of disease, changes in risk groups, as well as routes for testing. To get a picture of the burden of syph

Background: Late effects of polio (LEoP) is a progressive condition leading to a lifelong disability that can affect mental health. There is limited knowledge of depressive symptoms and associated factors in people with LEoP. Objective: To assess the occurrence of depressive symptoms in people with LEoP and explore the association with sociodemographic and disability-related factors. Design: Cross

Background: Right ventricular dysfunction (RVD) is a marker of adverse outcomes in heart failure (HF). We used a 5-point RVD score to describe three phenotypes (preserved RV function, RVD and RV failure) and investigated their relationhip with cardiac function and their contribution to risk stratification. Methods: Patients (n = 201) with HF, undergoing right heart catheterization and echocardiogr

The exponential rise in atmospheric CO₂ driven by human activities is accelerating climate change and causing ocean acidification (OA). While the effects of elevated CO₂ on a wide range of marine species have been well documented, the implications of OA for bivalve aquaculture have received comparatively little attention. Using a multi-level meta-analytical approach, we evaluated the impacts of tw

Traditional data sources on bushfire evacuation behaviour, such as quantitative surveys and manual observations have severe limitations. Mining social media data related to bushfire evacuations promises to close this gap by allowing the collection and processing of a large amount of behavioural data, which are low-cost, accurate, possibly including location information and rich contextual informat

Introduction Autistic persons experience problems with movements and body awareness in everyday functionality, expressed in affected movement quality. Yet, there is a knowledge gap about the effects of interventions targeting these aspects in autistic persons. Objective To evaluate effects of Basic Body Awareness Therapy (BBAT) and treatment-as-usual (TAU), compared to TAU alone on movement qualit

Catalytic active phases are often separated from inactive ones by their appearance/removal in heating/cooling experiments. Such experiments can reveal ignition, extinction, and often an associated hysteresis. The corresponding behavior and hysteresis under rapid gas composition changes in the milliseconds regime remain largely unexplored. However, such experiments can potentially be highly rewardi

The differentiation of proplastids into chloroplasts is driven by light and closely linked to the process of chlorophyll biosynthesis. Chloroplasts, while essential for photosynthesis, also generate reactive oxygen species (ROS), necessitating robust antioxidant mechanisms such as superoxide dismutases (SODs). SODs catalyze the detoxification of superoxide radicals to molecular oxygen and hydrogen

ZnS nanoparticles co-doped with Ni–Cr and Ni–Cu were synthesized by chemical precipitation and systematically examined for structural, optical, magnetic, and magneto-transport properties. All samples retained the cubic zinc blende phase with nanoscale crystallinity. Optical studies showed that Ni doping induced bandgap narrowing through sp-d exchange, while Cu and Cr introduced Burstein-Moss-type

Early kidney function decline may be associated with reduced filtration of middle-sized molecules, currently defined as selective glomerular hypofiltration syndrome (SGHS), and driven by the accumulation of atherosclerosis-promoting proteins. We aimed to investigate whether SGHS and other markers of kidney function are associated with subclinical atherosclerosis as evaluated by intima-media thickn

Closed-form conditions for bound states in the continuum are derived for planar, cylindrical, and spherical cavities enclosed by metasurfaces with electric and magnetic response. While the combined response in lossless systems enables field confinement in arbitrarily small cavities, the gain-enabled bound states in the continuum are found to coalesce with a laser mode, leading to intriguing single

Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming that allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms by which cancer cells exploit the epigenetic regulatory machinery to acquire lineage plasticity and therapy resistance remain poorly understood. We identified zinc finger protein 397 (ZNF397) as a bona fi

Water structure is crucially important to protein function and catalysis and can be conserved throughout related proteins despite differences in sequence. The complex hydrogen-bonding networks formed by water molecules and protein residues have been studied extensively, and graph-theory-based methods have frequently been used to describe these networks. Although there exist a number of tools which

The use of organic active materials in redox flow batteries (RFBs) presents a promising approach to sustainable large-scale energy storage. However, the stability of nonaqueous organic RFB electrolytes is generally limited by degradation reactions that cause capacity fade. These reactions are commonly thought to convert redox-active organics to products that are no longer electrochemically active.

Online teaching for place-based experiential learning is a rather new practice that can be used to create a more engaging and comprehensive learning experience. Though, it is a challenge to deliver experiential learning and place-based education in online teaching. This paper reports how we tackled this challenge in the pedagogical development of an interdisciplinary course within the European Uni