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Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the sprin
Adipose-derived mesenchymal stem cells (ADSCs) are promising candidates for novel cell therapeutic applications. Hibernating brown bears sustain tissue integrity and function via unknown mechanisms, which might be plasma borne. We hypothesized that plasma from hibernating bears may increase the expression of favorable factors from human ADSCs. In an experimental study, ADSCs from patients with isc
AIM: The aim of this study was to describe Norwegian healthcare staffs' experiences of participating in care of patients with Ebola virus disease in Sierra Leone.BACKGROUND: Ebola is one of the most feared viruses known. Ebola virus disease is highly contagious with high mortality. The few qualitative studies made on experiences among healthcare professionals have highlighted problems as lack of p
We present a detailed analysis of HARPS-N radial velocity observations of K2-100, a young and active star in the Praesepe cluster, which hosts a transiting planet with a period of 1.7 d. We model the activity-induced radial velocity variations of the host star with a multidimensional Gaussian Process framework and detect a planetary signal of 10.6 ± 3.0 m s−1, which matches the transit ephemeris,
Some theories of planet formation and evolution predict that intermediate-mass stars hostmore hot Jupiters than Sun-like stars, others reach the conclusion that such objects are very rare. By determining the frequencies of those planets we can test those theories. Based on the analysis of Kepler light curves it has been suggested that about 8 per cent of the intermediate-mass stars could have a cl
We report the discovery from K2 of two transiting hot Jupiter systems. K2-295 (observed in Campaign 8) is a K5 dwarf which hosts a planet slightly smaller than Jupiter, orbiting with a period of 4.0 d. We have made an independent discovery of K2-237 b (Campaign 11), which orbits an F9 dwarf every 2.2 d and has an inflated radius 60–70% larger than that of Jupiter. We use high-precision radial velo
Migratory birds must make complex decisions to use wind to their advantage during flight and increasing flight performance is particularly important while crossing ecological barriers. Age-related differences in how birds deal with wind have suggested experience improves necessary skills in gaining positive wind support. However, differences in wind support between age groups over ecological barri
SUMMARY We aimed to assess whether the characteristics of influenza-like illness (ILI) cases in the general population were similar during the seasonal and pandemic A(H1N1)pdm09 influenza periods. We conducted a study using a general population database, which included demographic (sex, age) and clinical (underlying medical conditions, influenza vaccination status) information on more than 80 000
We report the discovery of a super-Earth and a sub-Neptune transiting the star HD 15337 (TOI-402, TIC 120896927), a bright (V = 9) K1 dwarf observed by the Transiting Exoplanet Survey Satellite (TESS) in Sectors 3 and 4. We combine the TESS photometry with archival High Accuracy Radial velocity Planet Searcher spectra to confirm the planetary nature of the transit signals and derive the masses of
Background: Prostate cancer spinal bone metastases can have a radiographic profile that mimics multiple myeloma. Objective: To analyse the presence and prognostic value of myeloma-like prostate cancer bone metastases and its relation to known clinical, molecular, and morphological prognostic markers. Design, setting, and participants: A cohort of 110 patients with prostate cancer who underwent sur
We report the discovery of two transiting planets orbiting K2-290 (EPIC 249624646), a bright (V = 11.11) late F-type star residing in a triple-star system. It was observed during Campaign 15 of the K2 mission, and in order to confirm and characterize the system, follow-up spectroscopy and AO imaging were carried out using the FIES, HARPS, HARPS-N, and IRCS instruments. From AO imaging and Gaia dat
We study the geometric significance of Leinster’s notion of magnitude for a compact metric space. For a smooth, compact domain X in an odd-dimensional Euclidean space, we show that the asymptotic expansion of the function MX(R) = Mag(R·X) at R = ∞ determines the Willmore energy of the boundary ∂X. This disproves the Leinster-Willerton conjecture for a compact convex body in odd dimensions.
To estimate the effect of the introduction of the 7- and 10-valentpneumococcal vaccines in 2006 and 2011, respectively in the Netherlands, we assessed respiratory antibiotic use in one to nine year-old children between 2002 and 2013. Seasonal autoregressive integrated moving-average models were applied to estimate the percentage reduction in respiratory antibiotic use. When compared with the pre-v
We report on the confirmation and mass determination of a transiting planet orbiting the old and inactive G7 dwarf star HD 219666 (M∗ = 0.92 ± 0.03 M⊙, R∗ = 1.03 ± 0.03 R⊙, τ∗ = 10 ± 2 Gyr). With a mass of Mb = 16.6 ± 1.3 M⊙, a radius of Rb = 4.71 ± 0.17 R⊙, and an orbital period of Porb ≃ 6 days, HD 219666 b is a new member of a rare class of exoplanets: the hot-Neptunes. The Transiting Exoplanet
Planet host stars with well-constrained ages provide a rare window to the time domain of planet formation and evolution. The NASA K2 mission has enabled the discovery of the vast majority of known planets transiting stars in clusters, providing a valuable sample of planets with known ages and radii. We present the discovery of two planets transiting K2-264, an M2 dwarf in the intermediate age (600
We present the discovery and characterization of a new transiting planet from Campaign 17 of the Kepler extended mission K2. The planet K2-292 b is a warm sub-Neptune on a 17 day orbit around a bright (V = 9.9 mag) solar-like G3 V star with a mass and radius of M∗ = 1.00 ± 0.03 MȮ and R∗ = 1.09 ± 0.03 RȮ, respectively. We modeled simultaneously the K2 photometry and CARMENES spectroscopic data and
While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuani
Context. The Kepler extended mission, also known as K2, has provided the community with a wealth of planetary candidates that orbit stars typically much brighter than the targets of the original mission. These planet candidates are suitable for further spectroscopic follow-up and precise mass determinations, leading ultimately to the construction of empirical mass-radius diagrams. Particularly int
Despite the importance that goals have for language learning (Lee & Bong, 2019), little is known about the effects on learner behaviours. Combining individualized (idiographic) and standardized (nomothetic) methodologies, this study investigated whether the self-concordance of learning goals formulated at the beginning of a program of language education affected engagement and resilience at th
We report the independent discovery and characterization of two K2 planets: K2-180b, a mini-Neptune-sized planet in an 8.9-d orbit transiting a V=12.6mag, metal-poor ([Fe/H] = -0.65 ± 0.10) K2V star in K2 campaign 5; K2-140b, a transiting hot Jupiter in a 6.6-d orbit around a V=12.6mag G6V ([Fe/H] = +0.10 ± 0.10) star in K2 campaign 10. Our results are based on K2 time-series photometry combined w
