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Safinamide in the treatment pathway of Parkinson’s Disease : a European Delphi Consensus

Safinamide is a highly selective, reversible MAO B-inhibitor recently marketed in European and North American countries. To better define clinical indications regarding motor and non-motor symptoms, targeted population and safety of this compound, ten movement disorders specialists, experts in their field, convened and developed a panel of statements on: the role of glutamate in Parkinson’s diseas

Dual action of the cannabinoid receptor 1 ligand arachidonyl-2′-chloroethylamide on calcitonin gene-related peptide release

Background: Based on the current understanding of the role of neuropeptide signalling in migraine, we explored the therapeutic potential of a specific cannabinoid agonist. The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglio

Origins, motives and challenges in Western-Chinese research collaborations amid recent geopolitical tensions - Findings from Swedish-Chinese research collaborations

Until recently, modern science had been dominated by a handful of Western countries. However, since the turn of the millennium the global science landscape has undergone dramatic changes. The number of nations where a significant proportion of research done is of high international standard has now increased considerably. China particularly stands out and is today one of the leading science nation

Short-term effects of postural taping on pain and forward head posture : a randomized controlled trial

Background: Balance Body Tape (BBT) is a recently developed taping-method with the aim to reduce pain and improve posture through change in movement behavior. However, the potential effects of a treatment with BBT are scarcely documented. Therefore, the aim with this study was to investigate the effect of a three-week Balance body tape-treatment on the intensity of perceived neck, shoulder and bac

A CSR perspective to foster employee creativity in the banking sector : The role of work engagement and psychological safety

The entire service sector has acknowledged the importance of employee creativity. However, the underlying mechanism due to which employees are engaged in creativity has been relatively unexplored. Moreover, where the banking service sector in advanced countries has realized the potential role of employee creativity for a bank's success, the same was not fully realized in the context of a developin

Patient-reported outcomes one year after positive sentinel lymph node biopsy with or without axillary lymph node dissection in the randomized SENOMAC trial

Introduction: This report evaluates whether health related quality of life (HRQoL) and patient-reported arm morbidity one year after axillary surgery are affected by the omission of axillary lymph node dissection (ALND). Methods: The ongoing international non-inferiority SENOMAC trial randomizes clinically node-negative breast cancer patients (T1-T3) with 1–2 sentinel lymph node (SLN) macrometasta

Real-Time Emission and Exposure Measurements of Multi-walled Carbon Nanotubes during Production, Power Sawing, and Testing of Epoxy-Based Nanocomposites

The use of manufactured nanomaterials is increasing globally. Although multi-walled carbon nanotubes (CNTs) are used in a wide range of applications, only limited data are available on emissions and exposures during CNT composite production. No exposure data using portable aethalometers in the personal breathing zone (PBZ) to monitor occupational exposure to CNTs have yet been published. The aim o

Novel cardiovascular biomarkers associated with peripheral arterial disease in men screened for abdominal aortic aneurysm

Background: Peripheral arterial disease (PAD) is a common atherosclerotic disease with severity ranging from asymptomatic to chronic limb threatening ischemia. The aim of the present cross-sectional study was to identify novel biomarkers associated with PAD. Patients and methods: Levels of 91 cardiovascular specific proteins in plasma samples were measured by the Proseek Multiplex CVD III96x96 pa

A critical review of disproportionality in loss and damage from climate change

The notion of disproportionate impacts of climate change on certain groups and regions has long been a part of policy debates and scientific inquiry, and was instrumental to the emergence of the “Loss and Damage” (L&D) policy agenda in international negotiations on climate change. Yet, ‘disproportionality’ remains relatively undefined and implicit in science on loss and damage from climate cha

Understanding users' needs is important for the adoption of cleaner biomass cook stoves

elwood is the main source of cooking and heating energy for households in rural sub-Saharan Africa. Unfortunately, most of these households use inefficient biomass cook stoves, leading to consumption of more fuel and exposure to indoor air pollutants and associate health problems which disproportionately affect women and children. However, adoption of cleaner biomass cook stoves has remained low w

Role of Proneurotensin in Cardiometabolic Diseases

The burden of cardiometabolic diseases is increasing worldwide. Early detection of high-risk individuals is essential for appropriate diagnosis, better treatment outcomes, quality of life and lower health related costs. Aims: The overall aim of this thesis is to investigate the possible associations between plasma proneurotensin (Pro-NT) and risk of cardiovascular disease (CVD), type 2 diabetes (T

The investment climate in Turkmenistan: Challenges and possible ways of attracting foreign investment

This research report was prepared in the framework of the EU-funded project “Central Asian Law: Legal Cultures and Business Environments in Central Asia” (project number 870647 H2020 MSCA-RISE 2019-2023), which runs from 01/03/2020 through 28/02/2024. The project is coordinated by Lund University, and the project consortium includes European universities (University of Zurich, Charles University P