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Operational Definitions of Treatment Response and Remission in Obsessive-Compulsive Disorder Capture Meaningful Improvements in Everyday Life

Introduction: The operational definitions of treatment response, partial response, and remission in obsessive-compulsive disorder (OCD) are widely used in clinical trials and regular practice. However, the clinimetric sensitivity of these definitions, that is, whether they identify patients that experience meaningful changes in their everyday life, remains unexplored.Objective: The objective was t

Optimal Landfill Site Selection for Solid Waste of Three Municipalities Based on Boolean and Fuzzy Methods: A Case Study in Kermanshah Province, Iran

In recent decades, population increase and urban development have led to catastrophic environmental consequences. One of the principal objectives to achieve “sustainable development” is to find suitable landfills. Due to their physical characteristics, which have led to a lack of landfill sites and closeness to water bodies, agricultural fields, and residential areas, the cities of Javanrood, Pave

In the Name of Energy Efficiency : Justice and energy poverty in the energy transition of Swedish housing

The energy transition of housing is accelerating in parallel with economic inequality reaching historically high levels. There is thus an opportunity to reduce inequalities in living conditions, but also a risk that the costs of the transition are unequally distributed and aggravate existing inequalities. In order to seize the opportunity for a just transition, and in tandem enable a meaningful inThe energy transition of housing is accelerating in parallel with economic inequality reaching historically high levels. There is thus an opportunity to reduce inequalities in living conditions, but also a risk that the costs of the transition are unequally distributed and aggravate existing inequalities. In order to seize the opportunity for a just transition, and in tandem enable a meaningful in

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The postoperative course and final outcome after evacuation of subdural haematoma are described in 106 male patients in relation to their alcohol consumption. One-third of the patients were alcohol abusers, drinking at least 60 g of ethanol daily. Despite comparable head trauma, they had a significantly higher incidence of acute subdural haematomas and showed increased postoperative morbidity and

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As part of aiming towards a non-smoking hospital environment, staff at a Copenhagen university hospital were offered participation in a differentiated smoking cessation programme. This consisted of lectures, group therapy, follow-up visits and individually tailored nicotine replacement therapy free-of-charge for six weeks. Three hundred and seventy-four employees started the programme, with 353 co

Landscape-scale diversity of plants, bumblebees and butterflies in mixed farm-forest landscapes of Northern Europe : Clear-cuts do not compensate for the negative effects of plantation forest cover

To assess the biodiversity consequences of contemporary land-use trends in Northern Europe, where agriculture is being replaced by forestry, we need a better knowledge of the contributions of constituting habitats to biodiversity. Here, we use purposefully collected data from 87 sites to model how agricultural habitats, including semi-natural pastures, sown temporary grassland (leys), cereal crops

Tissue response curve shape analysis of dynamic glucose enhanced (DGE) and dynamic contrast enhanced (DCE) MRI in patients with brain tumor

Dynamic glucose enhanced (DGE) MRI is used to study the signal intensity time course (tissue response curve) after D-glucose injection. D-glucose has potential as a biodegradable alternative or complement to gadolinium-based contrast agents, with DGE being comparable to dynamic contrast enhanced (DCE) MRI. However, the tissue uptake kinetics as well as the detection methods of DGE differ from DCE,

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Postoperative morbidity after hysterectomy was studied prospectively in 229 consecutive patients in our departments. The incidence of alcohol abuse (> or = 60 gm of alcohol daily) and moderate drinking (between 25 and 60 gm of alcohol daily) was 6.5% for each. When compared with the moderate drinkers and the control group, the alcohol abusers developed significantly more complications (80% versus

Sparse Codes on Graphs with Convolutional Code Constraints

Modern coding theory is based on the foundation of the sparse codes on graphs, such as the low-density parity-check (LDPC) codes, and the turbo-like codes (TCs) with component convolutional codes. The success of the LDPC codes and the TCs lies in their ability to perform low-complexity iterative message passing decoding procedures. The iterative message passing decoders that exchange messages prob

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Retrospective studies suggest increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk associated with alcohol intake among patients undergoing surgery. We investigated 15 persons who required colorectal surgery and who were drinking at least five Danish drinks per day. These patients were matched for sex, nutrition, age, weight, cardio-pulmonary disease, di

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The aim of the study was to investigate to which degree and how fast cellular immunodepression may be reversed after cessation of alcohol intake. Delayed hypersensitivity was investigated in ten severe alcoholics and in seven moderate consumers. A group of eight previous drinkers was tested for comparison. The skin test responses were modest initially with a median area of response of 12 mm2 in th

Cancer morbidity in alcohol abusers

Data on the association between alcohol abuse and cancer morbidity are scarce in large cohorts of non-hospitalised alcoholic men and women. Of 18, 368 alcohol abusers who entered an outpatient clinic in Copenhagen during 1954-87, 18, 307 were followed and their cancer incidence was compared with that of the total Danish population. On average the 15, 214 men were observed for 12.9 years and the 3,

Reversibility of alcohol‐induced immune depression

Alcohol abusers have suppressed cellular immune function. The aim of the study was to investigate the time of sobriety required to normalize immune function. Delayed hypersensitivity was investigated during disulfiram controlled abstinence in ten heavy alcoholics and in seven moderate drinkers without liver diseases. For comparison a control group of eight previous drinkers was tested. The skin te

Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk NB and applied this protocol to mice with MYCN-amplified NB patient-derived xenografts (PDXs). Genomic and transcriptomic analyses were used to reveal NB chemoresistance mechan

The influence of alcoholism on outcome after evacuation of subdural haematoma

The postoperative course and final outcome after evacuation of subdural haematoma are described in 106 male patients in relation to their alcohol consumption. One-third of the patients were alcohol abusers, drinking at least 60 g of ethanol daily. Despite comparable head trauma, they had a significantly higher incidence of acute subdural haematomas and showed increased postoperative morbidity and

Influence of alcohol intake on postoperative morbidity after hysterectomy

Postoperative morbidity after hysterectomy was prospectively studied in 229 consecutive patients in our departments. The incidence of alcohol abuse (>60 gm of alcohol daily) and social drinking (between 25 and 60 gm of alcohol daily) was 6.5% for each. When compared with the social drinkers and the control group, the alcohol abuse group had significantly more complications (80% vs 27% and 80% vs 1