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Cyclin-dependent kinases (CDKs) are activated by cyclins, which play important roles in dictating the actions of CDK/cyclin complexes. Cyclin binding influences the substrate specificity of these complexes in addition to their susceptibility to inhibition or degradation. CDK/cyclin complexes are best known to promote cell cycle progression in the mitotic cell cycle but are also crucial for importa
Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By developing a general approach that combines theory, experiment and simulation, we reveal, in molecular detail, the mechanisms of Aβ42 oligomer dynamics during
Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants
Objective: To determine whether brain volume is associated with functional outcome after acute ischemic stroke (AIS). Patients and Methods: This study was conducted between July 1, 2014, and March 16, 2019. We analyzed cross-sectional data of the multisite, international hospital-based MRI-Genetics Interface Exploration study with clinical brain magnetic resonance imaging obtained on admission for
BACKGROUND: Breastfeeding in public continues to be contentious with qualitative evidence confirming that women face many challenges. It is therefore important to gain understanding of not only the challenges but also what women perceive is helpful to breastfeed in public.METHODS: A cross-sectional study was conducted with women living in Australia, Ireland or Sweden currently breastfeeding or hav
Wet eldercare facilities constitute a type of harm reduction arrangements where goals of abstinence are abandoned in favour of goals of increased wellbeing for older people with long-term substance use disorder. The fact that residents are acknowledged as being active in their substance use results in challenges; harmful activities are witnessed by the staff in a context that has actually been cre
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-se
Most in vitro reporter gene assays used to assess estrogenic contamination are based on human estrogen receptor α (hERα) activation. However, fish bioassays can have distinct response to estrogenic chemicals and mixtures, questioning the relevance of human-based bioassays for assessing risk to this species. In this study, zebrafish liver cells stably expressing zebrafish ERβ2 (ZELHβ2) and human br
The main sources of non-exhaust particles around metro systems are the wear from wheel-rail contact, brake contact and the contact between mechanical parts in electric power systems. In order to predict the PM10 levels on underground metro platforms, the relation among time, train frequency and PM10 level should be investigated. Two types of particle emission models have previously been published
Background and aims Persistent neck pain is common and can be detrimental to the health of those who are affected. This is particularly common after neck trauma, where it poses a challenge to health care providers. In this paper, we present the design and results of a study aimed primarily at assessing the feasibility of a supervised exercise intervention for patients with persistent neck pain aft
Background: Precarious employment is a risk factor for poor mental health, particularly among young adults. Knowledge about how young people maintain their mental health while in a precarious employment situation is scarce. The aim of the study was to explore the meaning of precarious employment for young adults in Sweden and their strategies for maintaining good mental health. Methods: In-depth i
Background: Arginine vasopressin has complex actions in critically ill patients, involving vasoregulatory status, plasma volume, and cortisol levels. Copeptin, a surrogate marker for arginine vasopressin, has shown promising prognostic features in small observational studies and is used clinically for early rule out of acute coronary syndrome. The objective of this study was to explore the associa
This paper outlines promising avenues for empirical research on quantified control in healthcare work. A review of key insights from accounting, organization studies, and the emergent sociology of quantification indicates that numbers are productive as well as deceptive and seductive, that they enable control but can be evaded, and that they typically have unintended effects. It remains to be furt
In thin notched sheets under tensile loading, wrinkling appears on the sheet surface, specifically around the cracked area. This is due to local buckling and compression stresses near the crack surfaces. This study aims to numerically study the buckling behavior of a thin sheet with a central crack under tension. A numerical model of a notched sheet under tensile loading is developed using the fin
In this paper, we look at the terrain of Malcolm X's "failed rhetoric" as producing an apocalyptic refusal of world, and world making. This refusal finds its intensity from a distinct gnostic calculus, driving Malcolm X's political theology of names and worlds, seen in his oratory from the years 1962–1964. First, Malcolm X's nominal history is discussed in relation to the violence of naming and po
Creative AI (notably GANs and VAEs) can generate convincing fakes of video footage, pictures, graphics, etc. In order to conceptualize the societal role of creative AI a new conceptual toolbox is needed. The paper provides metaphors and concepts for understanding the functioning of creative AI. It shows how the role of creative AI in relation to FAT ideals can be enriched by a dynamic and construc
Berättigad kritik mot rättsväsendet eller okontrollerad pöbeljustis? I kölvattnet av #metoo-rörelsen kvarstår spänningen mellan de sociala mediernas virala rätt och rättsväsendets formella rätt. Rättsvetaren Linnea Wegerstad tar sig här an kärnan i den senaste tidens fem #metoo-relaterade förtalsåtal: konflikten mellan rätten att berätta om sexuellt våld och rätten att inte bli föremål för ryktess
