The last decade’s rise of the so-called “third frame” (or third generation) of Transformative Innovation Policies (TIP) has shifted focus of research and innovation investments from economic growth and competitiveness to also tackling societal challenges and generating broader environmental and societal impact. The evolution in rationale and aims for policy action also implies a need to adapt and The last decade’s rise of the so-called “third frame” (or third generation) of Transformative Innovation Policies (TIP) has shifted focus of research and innovation investments from economic growth and competitiveness to also tackling societal challenges and generating broader environmental and societal impact. The evolution in rationale and aims for policy action also implies a need to adapt and

The Applied Nuclear Physics Group at Lund University is constructing a prototype CANS (Compact Accelerator-driven Neutron Source). The CANS is based around a 3 MV, single-ended, Pelletron accelerator, which is used to impinge a 2.8 MeV deuterium beam into a beryllium target. The anticipated neutron production will be on the order of 1010 n/s in 4π sr. A further upgrade to the ion source of the Pel

Despite cervical cancer being a highly preventable disease, it is the fourth most common cancer among women in both incidence and mortality. Cervical cancer screening is crucial in preventing the disease. Women living with HIV (WLHIV) are at higher risk of cervical cancer because of their immune-compromised state. We aimed to determine factors associated with cervical cancer screening among WLHIV

This paper studies the relationship between income inequality and carbon emissions in the United States between 1929 and 2019. We contribute to the literature by considering how the relationship have varied over time. To this end we estimate a band spectrum regression model and a smooth-varying coefficients model. Our results show that higher inequality was associated with lower emissions during tThis paper studies the relationship between income inequality and carbon emissions in the United States between 1929 and 2019. We contribute to the literature by studying if and how the relationship has varied over time. To this end we estimate a band spectrum regression model and a smooth-varying coefficients model. Our results show that higher inequality was associated with lower emissions durin

Copper (Cu) is one of the most abundant trace metals in all organisms, involved in a plethora of cellular processes. Yet elevated concentrations of the element are harmful, and interestingly prokaryotes are more sensitive for environmental Cu stress than humans. Various transport systems are present to maintain intracellular Cu homeostasis, including the prokaryotic plasmid-encoded multiprotein pc

Severe congenital protein C deficiency (SCPCD) is rare and there is currently substantial variation in the management of this condition. A joint project by three Scientific and Standardization Committees of the ISTH: Plasma Coagulation Inhibitors, Pediatric/Neonatal Thrombosis and Hemostasis, and Women’s Health Issues in Thrombosis and Hemostasis, was developed to review the current evidence and h

Objectives: This study investigates the stability of neuropsychiatric symptoms (NPS) assessed biweekly using the Neuropsychiatric Inventory (NPI) in a memory clinic population during a 6 week period. Methods: Twenty-three spousal caregivers (mean [SD] age = 69.7 [8.8], 82.6% female) of 23 patients (43.5% had dementia) completed all assessments. The NPI was assessed four times during 6 weeks. We ex

4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin-3 (Gal-3) decreases the cellular response to its ligand (4-1BBL). Gal-3 binds to both soluble 4-1BB (s4-1BB) and membrane-bound 4-1BB (mem4-1BB), without blocking co-binding of 4-1BBL. In plasma, we detected complexes composed of 4-1BB and Gal-3 larger than 100 nm in

The traditional engineering approach to manage urban drainage is by combined or separated sewers. In urban catchments, drainage systems may include different types of storage and detention facilities to avoid flooding from heavy rainfall. However, during recent decades, alternative ways to manage floods have evolved since traditional methods often harm the riverine ecosystems by pollution and eros

Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are one of the strongest contributing factors to treatment resistance in GBM. Identification of biomarkers capable of directly affecting these cells within the bulk tumor is a major challenge associated with the development of new targeting strategies. In this study, we focus on understanding the potential of the multifunctional extraordinaire

Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell division and to avoid DNA damage and programmed cell death. Transition to the PACC state may also lead to an increase in the cancer cell’s ability to generate

Aims/hypothesis: Diabetes is associated with an increased risk of cancer. Prostasin is an epithelial sodium channel stimulator that has been associated with suppression of tumours, glucose metabolism and hyperglycaemia-associated tumour pathology. However, the association between prostasin, diabetes and cancer mortality has not been well investigated in humans. We aim to investigate the associatio

Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for ac

Although virtue ethics has repeatedly been proposed as a suitable framework for the development of artificial moral agents (AMAs), it has been proven difficult to approach from a computational perspective. In this work, we present the first technical implementation of artificial virtuous agents (AVAs) in moral simulations. First, we review previous conceptual and technical work in artificial virtu

In high performance gas turbine engines, the over tip leakage flow driven by the lateral pressure gradient is inevitably induced inside the blade tip gap in the high-pressure stage turbine due to the freestanding airfoil design methodology. To obtain an increasing level of thermal efficiency, the turbine inlet temperature is gradually increased in terms of the Brayton cycle. Hence, the blade tip a