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Congenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Since amniotic fluid comprises proteins of both fetal and maternal origin, its analysis could provide insights on mechanisms underlying CDH and provide biomarkers for early diagnosis, severity of pulmonary changes and treatment response. The stu

Background. National as well as international Parkinson's disease (PD) treatment guidelines are available to guide clinicians. Previous research has shown that nonmotor symptoms (NMS) are pronounced in late-stage PD and has suggested that current treatment is insufficient and could be improved. Objectives. The aim of this study was to investigate to which degree the national and international trea

How was the scope of nuclear weapons policy change immediately after the Cold War determined? Nuclear learning and worst-case thinking are common but not satisfactory answers. On the basis of primary sources in multiple languages, we posit that a particular temporalization of nuclear events in the beginning of the 1990s took place: nonproliferation timescaping. The Iraqi case of opaque proliferati

Performative and philosophical approaches to contemporary theatre and performance art.Book based on my PhD.

Social workers often fail to engage fathers in child protection investigations (CPIs), especially when they involve domestic abuse (DA) by fathers. The aim of this study is to examine the strategies used by social workers to achieve cooperation with fathers in CPIs that involve the father being suspected of DA against the child's mother. With the use of qualitative methods, we conducted 31 semi-st

Characterising the interaction between cationic ionisable lipids (CIL) and nucleic acids (NAs) is key to understanding the process of RNA lipid nanoparticle (LNP) formation and release of NAs from LNPs. Here, we have used different surface techniques to reveal the effect of pH and NA type on the interaction with a model system of DOPC and the CIL DLin-MC3-DMA (MC3). At only 5% MC3, differences in

We present a novel class of minimax optimal control problems with positive dynamics, linear objective function and homogeneous constraints. The proposed problem class can be analyzed with dynamic programming and an explicit solution to the Bellman equation can be obtained, revealing that the optimal control policy (among all possible policies) is linear. This policy can in turn be computed through

Factors behind intraspecific variation in sensitivity to pathogens remain poorly understood. We investigated how geographical origin in two North European amphibians affects tolerance to infection by the chytrid fungus Batrachochytrium dendrobatidis (Bd), a generalist pathogen which has caused amphibian population declines worldwide. We exposed newly metamorphosed individuals of moor frog Rana arv

Aims: Infections are proposed risk factors for type 1 diabetes in children. We examined whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults (LADA). Materials and methods: We used data from a population-based Swedish case-control study with incident cases of LADA (n = 597) and matched controls (n = 2386). The history of infectious disease

We study a Dirichlet boundary problem related to the fractional Laplacian in a manifold. Its variational formulation arises in the study of magnitude, an invariant of compact metric spaces given by the reciprocal of the ground state energy. Using recent techniques developed for pseudodifferential boundary problems we discuss the structure of the solution operator and resulting properties of the ma

Cognitive decline in Alzheimer's disease and other dementias typically begins long before clinical impairment. Identifying people experiencing subclinical decline may facilitate earlier intervention. This study developed cognitive trajectory clusters using longitudinally based random slope and change point parameter estimates from a Preclinical Alzheimer's disease Cognitive Composite and examined

Sovereign is who decides; and who decides is responsible. The book develops these two arguments by comparing Carl Schmitt's and Dietrich Bonhoeffer's theories of sovereignty.Carl Schmitt was an influential jurist of Nazi Germany. Dietrich Bonhoeffer was a Lutheran priest hanged for his involvement in a plot to assassinate Adolf Hitler. In many ways, the two men could not be more different. But the