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Coping with complexity. multivariate analysis of tumor karyotypes.

Human cancers are characterized by chromosomal aberrations, and an increasing number of specific balanced rearrangements have been found among malignant hematologic disorders. Most solid tumors, however, exhibit a much more complex cytogenetic pattern. Although these chromosome changes show a nonrandom distribution, tumor-specific aberrations are uncommon, and the solid tumors often contain a larg

Endocardial expression and functional characterization of endothelin-1

Endothelin-1 (ET-1), a 21 amino acid peptide exerts a wide range of biological activities including vasoconstriction, mitogenesis and inotropic effects on the heart. In this study, we examined whether endocardial endothelial cells express ET-1 and evaluated its functional properties. Using immunofluorescence localization method, we demonstrated cytoplasmic staining of ET-1 in the human endocardial

Heat transfer augmentation in an oscillating flow

For combustors a heat transfer augmentation of two to five times higher than expected has been reported. Experiments, where the temperature profile in the tail pipe of the pulse combustor has been measured, give no indication why the heat transfer should be augmented. The objective is to study the heat transfer of an oscillating flow between two parallel plates. A set of governing equations is for

Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases

OBJECTIVES: To investigate the significance of ACE gene insertion/deletion (I/D) polymorphism in the frequency of autoimmune manifestations in sarcoidosis. DESIGN: In patients with sarcoidosis the ACE gene I/D polymorphism was detected with PCR on genomic DNA. The patients with sarcoidosis were divided according to the presence (n = 30) or absence (n = 32) of autoimmune manifestations. The former

Religionskritik i en postmodern tid

I en postmodern kontext blir traditionell religionskritik, som bygger på förnekandet av Guds metafysiska existens, irrelevant. Speciellt gäller detta när religionen förstås anti-realistiskt. Möjligheten till religionskritik är därmed dock inte uttömd hävdar artikeln. Exempelvis kan relevansen av en religiös reaktion inför existentiella erfarenheter ifrågasättas. En sammanvägning görs av hur religi

Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations

Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease. Expression of properdin by monocytes was examined in type I deficiency and in two unrelated cases with type II deficiency, one from a Swedish and one from a Da

Mean force between like-charged macroions at high electrostatic coupling

Interactions between two like-charged macroions in the presence of their counterions confined in a cylindrical cell have been investigated by Monte Carlo simulations. The mean force and the potential of mean force (pmf) as a function of the macroion separation have been determined at conditions at which short-range attractions become significant. As the electrostatic coupling is increased, the nat

Interaction between microclimate and concrete--a prerequisite for deterioration

This paper gives an overview of the present knowledge regarding the interaction between the climatic conditions at the concrete surface and the corresponding conditions inside the concrete. The phenomena dealt with are those involved in frost damage, frost and salt scaling and reinforcement corrosion, such as temperature and moisture conditions in the near surface regions, carbonation and chloride

Increased uptake of 5-FU in experimental liver tumours by simultaneous infusion of norepinephrine

The effect of the simultaneous administration of norepinephrine and 5-fluorouracil (5-FU) on the uptake of radiolabelled 5-FU by liver tumours was studied in rats. Three different concentrations of 5-FU were used (15, 1.5 and 0.15 microgram/g body weight). The drugs were infused over a 30 min period via the hepatic artery, following cannulation of the gastroduodenal artery. The radioactivity in li