The present study was designed to test the hypothesis of a diurnal variation of endothelial function. Sixteen healthy, nonsmoking women were studied, each on four occasions during one 24-h period (2:00 PM, 8:00 PM, 2:00 AM, and 8:00 AM). Endothelial function was assessed by ultrasound determinations of flow-mediated vasodilation (FMD%) in the brachial artery. FMD% was contrasted with endothelium-i

The potential role of inflammatory mechanisms in the pathophysiology of ischemic brain damage has intensely been discussed. We have recently demonstrated that stroke patients display an intrathecal production of proinflammatory cytokines early after onset of symptoms. IL-1beta, one of these cytokines, stimulates the production of nitric oxide (NO), a potent inflammatory mediator. The aim of the pr

A growing body of evidence points out the potential role of inflammatory mechanisms in the pathophysiology of brain damage in dementia. We have recently demonstrated that patients with Alzheimer's disease (AD) and vascular dementia (VaD) display an intrathecal production of proinflammatory cytokines. TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflamma

Transgenerational inheritance of environmentally induced epigenetic marks can have significant impacts on eco-evolutionary dynamics, but the phenomenon remains controversial in ecological model systems. We used whole-genome bisulfite sequencing of individual water fleas (Daphnia magna) to assess whether environmentally induced DNA methylation is transgenerationally inherited. Genetically identical

Hovrätten över Skåne och Blekinge inrättades 1820 och började sin verksamhet 1821. I denna bok beskrivs hovrättens historia under dess första 200 år – hur den inrättades och hur dess verksamhet har utvecklats i Kristianstad och Malmö. Dessutom beskrivs de rättsliga förhållandena i Skåne och Blekinge innan hovrätten fanns. Genom boken får läsaren på så sätt en överblick över de senaste tusen årens

This article examines the records of the so-called homo-sex commission—a part of the municipal Stockholm police force dedicated to the policing of male same-sex practices—as a case study of the role of policing in shaping historical understandings of homosexuality. Building on a series of documents left by the commission and high-ranking police officers, from memoranda describing the nature of hom

Purpose of Review: Companies increasingly set science-based targets (SBTs) for reducing greenhouse gas emissions. We review literature on SBTs to understand their potential for aligning corporate emissions with the temperature goal of the Paris Agreement. Recent Findings: SBT adoption by larger, more visible companies in high-income countries has accelerated. These companies tend to have a good pr

This article examines two Swedish TV theater plays from the late 1960s and early 1970s, which both portray the experience of waiting for an abortion. In the early 1960s, a major debate on abortion started in Sweden, which resulted in the creation of a public inquiry into the matter in 1965 and eventually the introduction of abortion on demand in 1975. In the period between 1965 and 1975, attitudes

The aim of this work is to investigate different methods to solve the problem of allocating the correct amount of resources (network bandwidth and storage space) to video camera systems. Here we explore the intersection between two research areas: automatic control and game theory. Camera systems are a good example of the emergence of the Internet of Things (IoT) and its impact on our daily lives

Critical infrastructures must be both robust and resilient in order to ensure the functioning of society. A key activity in ensuring their proper function is finding and addressing system weaknesses by the means of risk and vulnerability analysis. A critical factor of such analysis is the ability to determine the negative consequences of various types of contingencies. Numerous mathematical and si

Background: Further knowledge is needed regarding long-term outcome ofemotional symptoms, and the interplay between these symptoms and neuropsychological functioning in youth with attention deficit hyperactivity disorder (ADHD). Objective: We aimed to explore the effect of performance-based neurocognitive functions and parent-rated behavioral executive functioning (EF) on self-rated and parent-rat

Background: People with depression and anxiety disorder may experience occupational performance issues (OPIs). Further knowledge about these issues longitudinally and about potential differences between people is valuable. Aim: To explore experienced OPIs longitudinally in a sample living with depression and/or anxiety disorder participating in occupational therapy and varying in terms of their wo

Motivated by the pioneering activation-energy asymptotic analysis of strained laminar premixed flames in counterflow by Libby and his coworkers, a rate-ratio asymptotic analysis is carried out to elucidate the structure and predict the critical conditions of extinction of strained premixed methane flames. Steady, axisymmetric, laminar flow of two counterflowing streams: a reactive mixture stream a

Background: A feared cause of bacteraemia with Gram-positives is infective endocarditis. Risk stratification scores can aid clinicians in determining the risk of endocarditis. Six proposed scores for the use in bacteraemia; Staphylococcus aureus (PREDICT, VIRSTA, POSITIVE), non-β-haemolytic streptococci (HANDOC) and Enterococcus faecalis (NOVA, DENOVA) were validated for predictive ability and the

Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. Sialic acid plays a crucial role forpathogenic bacteria, since it is used as a source of car

Over the last decades, dramatic improvements in combinatorialoptimisation algorithms have significantly impacted artificialintelligence, operations research, and other areas. These advances,however, are achieved through highly sophisticated algorithms that aredifficult to verify and prone to implementation errors that can causeincorrect results. A promising approach to detect wrong results is tous

Background: The number of individuals aging with long-term spinal cord injury (SCI) is increasing. Still, there is limited knowledge about changes in secondary health conditions (SHCs) and activity limitations over time. Objectives: To determine changes in SHCs and activity limitations in older adults aging with long-term SCI over 6 years, and to investigate how changes in SHCs and activity limita