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It is easy when studying the literature on the current development toward closer more integrated business to business relationships to get the impression that a close integrated relationship is desired for all circumstances. Instead, this thesis shows that the nature of business relationship is very strongly correlated to product supplied. The focus of this thesis has been a case study between a s
This paper presents a 3rd-order, 3-bit continuous time (CT) Delta-Sigma modulator for an LTE radio receiver. By adopting a return-to-zero (RZ) pulse in the innermost DAC, the modulator shows a reduced sensitivity to loop-delay variations, and the additional loop delay compensation usually needed in CT modulators can be omitted. The modulator has been implemented in a 65nm CMOS process, where it oc
The setting for this study is Swedish film culture of the 1920s, which has been studied with a focus on representations of masculinity and gender relations according to four themes: 1) children and youth 2) fatherhood and love 3) sexuality and popularity 4) ethnicity and racial stereotyping. The rise of new consumer culture in the first decades of the 20th century created turmoil between traditi
Popular Abstract in Swedish Infektioner i urinvägar, tarm och luftvägar orsakas av bakterier som speciellt anpassats till respektive vävnad. Infektionen börjar med att bakterien binder till slemhinneytan, och därmed sätter igång inflammation och försvar. Urinvägsinfektioner (UVI) är en värdefull modell för att förstå de molekylära detaljerna som avgör balansen mellan värd och bakterie. UVI orsakaBacterial adhesion to the bladder mucosa is a critical step for the establishment of Escherichia coli bacteriuria. The P-fimbriae, encoded by the pap gene cluster, are considered as virulence factors but the mechanisms have been debated. This study defined the roles for P fimbriation during the early colonization of the human urinary tract. Patients with recurrent UTI were first subjected to deli
BACKGROUND: Eosinophils have a typical content of granule-bound, cytotoxic, cationic proteins which may, when released to the external milieu, play roles in diseases such as asthma and parasitic infestation. Therefore, we have investigated possible mechanisms by which their release is regulated in eosinophils. METHODS: The enzyme-linked immunosorbent assay (ELISA) was used to detect released eosin
The Aker metabasite occupies a key position in a major tectonic lineament in southernmost Sweden, the Protogine Zone, which coincides closely with the eastern boundary of the late Mesoproterozoic Sveconorwegian orogen of southwest Scandinavia. Metamorphic reactions, associated with the transformation from isotropic gabbro to foliated garnet amphibolite, were identified from disequilibrium textures
The aim of this study was to evaluate the relationship between respiratory symptoms, lung function and inflammatory markers in 'healthy' smokers. The study population was recruited from an epidemiological study with subjects of the same age, 60 years. Only smokers who considered themselves healthy (n=58) and a random sample of never-smokers (n=34) were investigated. All subjects underwent lung fun
OBJECTIVE: To compare the reliability of quantitative measurement of minimum hip joint space with a qualitative global assessment of radiological features for estimating the prevalence of primary osteoarthritis (OA) of the hip in colon radiographs.METHODS: All colon radiographs from patients aged 35 or older, taken at three different radiographic departments in Iceland during the years 1990-96, we
Objectives. To study the course of impairment measured by signals of functional impairment (SOFI) and disability measured by health assessment questionnaire (HAQ) over 20 years in rheumatoid arthritis (RA) patients followed from diagnosis. To explore the contribution of disease activity, joint damage and comorbidity to variation of SOFI and HAQ over time. Methods. RA patients diagnosed 1985-1989 w
The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor-selectivity by dipeptidyl-peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selecti
Thyroid hormone level has been positively associated with breast cancer risk and with breast cancer cell proliferation and growth. Although breast cancer is a heterogeneous disease, this is the first study assessing pre-diagnostic levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibodies (TPO-Ab) in relation to breast cancer s
Background: Hypertension is a major risk factor of Alzheimer's disease (AD); however, controlled studies on the effect of antihypertensive treatment on the risk of dementia are inconclusive. Therefore, a biological marker that predicts individual response to antihypertensive treatment would be of high clinical relevance. Midregional proatrial natriuretic peptide (MR-proANP), an inactive surrogate
Objective: In patients with type 2 diabetes mellitus (T2DM), biomarkers reflecting inflammation and endothelial dysfunction have been linked to cardiovascular disease (CVD biomarkers) and metabolic regulation. In T2DM patients, metformin and insulin secretagogues have demonstrated equal anti-hyperglycaemic potency. Here, we report the effect of metformin versus an insulin secretagogue, repaglinide
Inhibition of dipeptidyl peptidase-4 (DPP-4) is currently explored as a novel therapy of type 2 diabetes. The strategy has been shown to improve glycemia in most, but not all, rodent forms of glucose intolerance. In this study, we explored the effects of DPP-4 inhibition in mice with [beta-cell overexpression of human islet amyloid polypeptide (IAPP). We therefore administered the orally active an
Popular Abstract in Swedish 1100-talet var en mycket dynamisk och händelserik tid i dansk historia. Under detta århundrade ägde en rad samhällsförändringar rum som kom att påverka de allra flesta. På landsbygden samlades bebyggelsen i byar samtidigt som jordbruket rationaliserades och naturresurserna utnyttjades mer storskaligt. I städerna utvecklades penningekonomin och en mångfacetterad varuprodThe Early Middle Ages, comprising the period ca. 1000-1250, is usually described as a dynamic and eventful time, when many spheres of society underwent radical changes. The aim of this dissertation is to link these processes together in an overall holistic description of medieval society. The intention is thus to provide a "total historical" account of early medieval Denmark by means of a broad in
The present European Standard for footwear testing (EN 344) classifies footwear thermally by a temperature drop inside the footwear during 30 minutes at defined conditions. Today, other methods for footwear thermal testing are also available. The aim of this study was to compare EN 344 with thermal foot method. Six boots were tested according to both methods. Additional tests with modified standar
Mouse mammary tumor virus (MMTV)-like sequences have been found in up to 40% of breast cancer samples but in <2% of normal breast tissue samples from Australian women studied by our group. Screening of a larger and more diverse cohort of female breast cancer samples has now shown a correlation of MMTV-like sequences with the severity (grade) of breast cancer. Thirty-two percent (43 of 136) of fema
