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Background: Prostate cancer spinal bone metastases can have a radiographic profile that mimics multiple myeloma. Objective: To analyse the presence and prognostic value of myeloma-like prostate cancer bone metastases and its relation to known clinical, molecular, and morphological prognostic markers. Design, setting, and participants: A cohort of 110 patients with prostate cancer who underwent sur
Over the last decades, there has been a rapid increase of the number of climate change initiatives outside the UNFCCC. In research this is referred to as ‘institutional fragmentation’, and it encompasses a wide range of public, private and hybrid initiatives, at various levels of governance. This development is extensively discussed in the IPCC Fifth Assessment Report AR5. Chapters 13-16 of the Wo
Inducible defences allow prey to increase survival chances when predators are present while avoiding unnecessary costs in their absence. Many studies report considerable inter-individual variation in inducible defence expression, yet what underlies this variation is poorly understood. A classic vertebrate example of a predator-induced morphological defence is the increased body depth in crucian ca
Enterococcus faecalis cells can reduce ferric ions and other electron acceptors by extracellular electron transfer (EET). To find mutants with enhanced or defective EET, strain OG1RF with random transposon insertions in the chromosome was screened for ferric reductase activity by colony zymogram staining using the chromogenic ferrous-chelating compound Ferrozine. The screen revealed npr, eetB, and
Decisions to admit or refuse admission to intensive care for acute exacerbations of COPD (AECOPD) can be difficult, due to an uncertainty about prognosis. Few studies have evaluated outcomes after intensive care for AECOPD in patients with chronic respiratory failure requiring long-term oxygen therapy (LTOT). In this nationwide observational cohort study, we investigated survival after first-time
Background: The choice of rhythm control drugs for recurrent atrial fibrillation (AF) remains empirical and is based on the safety profile rather than predicted efficacy. Flecainide is recommended for prevention of AF recurrence in patients without structural heart disease however predictors of treatment success are insufficiently studied. Objective: To assess clinical characteristics associated w
Background: Digitalized work life can increase cognitive demands and influence people’s everyday life. This can be challenging for people with cognitive difficulties, yet there is scarce knowledge of how they manage these. It is essential to learn how self-initiated management strategies can be a resource to support sustainable work and everyday life. Aim: To describe how people with cognitive dif
Genomes of eusocial insects code for dramatic examples of phenotypic plasticity and social organization. We compared the genomes of seven ants, the honeybee, and various solitary insects to examine whether eusocial lineages share distinct features of genomic organization. Each ant lineage contains ∼4000 novel genes, but only 64 of these genes are conserved among all seven ants. Many gene families
Cucurbit crops have steadily increased in production over the last 50 years, particularly in Asia where pioneering technological advancements and genetic improvements have created new hybrid varieties. Generally, cucurbits are dependent on insect-pollination for fruit set and are popular species for pollination studies. This review systematically summarises pollination research conducted in the ma
The study of economic development in African countries is facing a basic problem of lack of reliable data and statistics. These problems of economic data are best addressed under three main categories: design, capacity, and politics. The focus is on gross domestic product (GDP), but the relevance goes beyond GDP statistics because the aggregate of GDP requires economic data on all sectors of the e
Mass-flowering crops provide forage for bees but also contain pesticides. Such pesticide exposure can harm bees, but our understanding of how this cost is balanced by forage benefits is limited. To provide insights into benefits and costs, we placed bumblebee colonies in 18 landscapes with conventional red clover fields treated with the neonicotinoid thiacloprid (flowers + pesticide), untreated or
