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Hyperglycemia and insulin infusion in pancreatoduodenectomy : a prospective cohort study on feasibility and impact on complications

BACKGROUND: Hyperglycemia is a risk factor for postoperative complications but its impact on outcome after pancreatoduodenectomy (PD) is scarcely studied. This prospective cohort study aimed to assess the effect of continuous insulin infusion on postoperative complications and blood glucose, as well as to evaluate the impact of hyperglycemia on complications, after PD. MATERIALS AND METHODS: One h

Secondary malignancies among mantle cell lymphoma patients

Purpose: With modern treatments, mantle cell lymphoma (MCL) patients more frequently experience long-lasting remission resulting in a growing population of long-term survivors. Follow-up care includes identification and management of treatment-related late-effects, such as secondary malignancies (SM). We conducted a population-based study to describe the burden of SM in MCL patients. Methods: All

Abnormally high exertional breathlessness predicts mortality in people referred for incremental cycle exercise testing

Background Exertional breathlessness is a key symptom in cardiorespiratory disease and can be quantified using incremental exercise testing, but its prognostic significance is unknown. We evaluated the ability of abnormally high breathlessness intensity during incremental cycle exercise testing to predict all-cause, respiratory, and cardiac mortality. Study design and methods Longitudinal cohort s

Comparing Treatment Outcomes of Eligible Patients Consenting to or Declining Randomization in a Randomized Clinical Trial A Secondary Analysis of the FISH Trial on Humeral Shaft Fractures

Background: The Finnish Shaft of the Humerus (FISH) trial compared open reduction and internal plate fixation (ORIF) with functional bracing in adult patients with displaced, closed humeral shaft fractures. Here, we compare the results of the patients in the randomized clinical trial (RCT [the randomized cohort]) with those of the cohort of patients who were also eligible but declined randomizatio

Evolution of leapfrog migration : A test of competition-based hypotheses

Leapfrog migration is a common migration pattern in birds where the breeding and wintering latitudes between populations are in reversed latitudinal sequence. Competition for wintering and breeding sites has been suggested to be an ultimate factor, and several competitor-based hypotheses have been proposed to explain this pattern. If wintering sites close to the breeding sites are favored, competi

Treating shock with norepinephrine administered in midline catheters in an intermediary care unit : A retrospective cohort study

Objectives A rising incidence of septic shock as well as recommendations for early vasopressor initiation has increased the number of patients eligible for norepinephrine (NE). Traditionally, NE has been administered through central lines, in intensive care units, due to the risk of extravasation in peripheral lines. The aim of the current study is to determine the rate of complications and patien

Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes : a Danish 12 year cohort study

Aims/hypothesis: A better understanding of the mechanisms underlying an elevated infection risk in individuals with type 2 diabetes is needed to guide risk stratification and prevention. We investigated the risk of infection in subgroups of individuals with type 2 diabetes according to indices of insulin sensitivity and beta cell function. Methods: We classified 7265 individuals with recently diag

Morality as a labour of love : Digital games, parental practices and the moral economy

The ways in which we experience life through, with and around media constitutes creative practices in our daily routines. However, media use is in part associated with harmful effects, for example television viewing amongst children and young people (Livingstone 2009). Discourses around digital games have been echoing the same type of concerns, becoming one of the focal points of these struggles i

Cult Film Atmospheres : Audiences, exhibitors, and live cinema spaces

Kultfilmsevenemang som Den Dåliga Filmfestivalen (Göteborg, 2019 och 2023-2025) och B-Filmsklubben (Malmö) erbjuder unika atmosfärer för publiken som besöker dem. I Malmö och Göteborg anordnar biograferna regelbundet festivaler och fristående visningar av kultfilmer som band andra The Room, Birdemic, och Miami Connection. Kännetecknande för dessa upplevelser är den översvallande atmosfär som skapa

The Emergence and Development of the Danish Modal Particle Paradigm

This dissertation investigates the development of the main Danish modal particles jo, sgu, skam, nu, da, vel, nokand vist. In Modern Danish, these particles express contextualization instructions, that is, they express how theutterance relates to the interactive context. In addition to this common content core, they also share severalexpression features: they cannot be placed in the pre-field, the

Current evidence of oral anticoagulant reversal : A systematic review

Introduction Approximately 4–6% of patients treated with oral anticoagulants (OAC) will suffer from major hemorrhage or be in need of urgent surgery necessitating anticoagulant reversal therapy. Several new oral anticoagulants and reversal agents have been introduced that make it difficult for physicians to stay updated on the current evidence of reversal management. This study aims to review the

Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults

Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms

Accuracy of self-reported family history of cancer, mutation status and tumor characteristics in patients with early onset breast cancer

Background: The main objectives of this study were to evaluate the concordance between self-reported and registry-reported information regarding family history of breast cancer (BC), ovarian cancer (OvC) and other types of cancer in first-degree relatives of patients with early onset BC, and to determine the frequency of mutation carriers and non-mutation carriers. The secondary objective was to d

Policy Framework for Material Resource Efficiency : Pathway Towards a Circular Economy

The strategic direction of the European Union (EU) over the past twenty years has focused on increasing resource productivity and innovation in the economy, aiming at the efficient use and secured supplies of resources, economic growth and job creation, with fewer environmental impacts. One of the basic premises of the new ‘Green Deal’ for Europe is the promotion of the circular economy. The aim o

Pacing therapy in the management of unexplained syncope : A tertiary care centre prospective study

Objective Pacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope. Methods Among 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

Objective To evaluate the effect of midlife lipid levels on Alzheimer brain pathology 20 years later in cognitively normal elderly individuals.Methods This is a longitudinal cohort study of 318 cognitively normal individuals with data on fasting lipid levels at midlife (mean age 54 years). Presence of β-amyloid (Aβ) and tau pathologies 20 years later (mean age 73 years) were detected by quantifyin

One-hour glucose value as a long-term predictor of cardiovascular morbidity and mortality : the Malmö Preventive Project

OBJECTIVE: To examine the predictive capability of a 1-h vs 2-h postload glucose value for cardiovascular morbidity and mortality.DESIGN: Prospective, population-based cohort study (Malmö Preventive Project) with subject inclusion 1974-1992.RESULTS: Median age was 48 (25th-75th percentile: 48-49) years and mean FBG 4.6 ± 0.6 mmol/L. FBG and 2-h postload BG did not independently predict cardiovascu