Importance: There is currently no consensus as to which biomarkers best predict longitudinal tau accumulation at different clinical stages of Alzheimer disease (AD). Objective: To describe longitudinal [18F]RO948 tau positron emission tomography (PET) findings across the clinical continuum of AD and determine which biomarker combinations showed the strongest associations with longitudinal tau PET

Sammanfattning Selektiva distributionsavtal används inom många branscher som ett sätt att reglera handeln med produkter och som ett verktyg för att selektera återförsäljarna. Det senaste året har dessa avtal kommit att nyttjas även inom klockbranschen. Det är en speciell bransch där varumärkena får allt större betydelse och det bidrar till en starkare position för de företag som äger och levererar

BACKGROUND: We are exposed to several chemicals such as persistent organic pollutants (POPs) in our everyday lives. Prior evidence has suggested that POPs may have adverse effects on reproductive function by disrupting hormone synthesis and metabolism. While there is age-related decline of fertility, the use of hormonal combined oral contraceptives (COCs) and its association to return of fertility

Sin ringa storlek till trots har insekter enorm inverkan på vårt samhälle och våra liv. Bin, som är centrala för att vårt jordbruk ska fungera, har minskat drastiskt i antal de senaste åren. En utbredd bidöd skulle i bästa fall tvinga oss lägga om vår kosthållning markant, och i värsta fall leda till svält. Utöver detta skulle växter som är beroende av bin för sin fortplantning och djur som äter bThis thesis treats entomological lidar from various angles: laboratory reference work on insects of interest, methodological development of lidar- and data processing methods, as well as field implementations of lidar techniques for entomological research. Insects are crucial components of ecosystems and are currently in a global decline. In this thesis, insects are mainly studied in their roles a

AIMS/HYPOTHESIS: Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and beta cell mass.METHODS: Pancreas tissue from 15 non-diabetic organ donors who were positive for islet

På senare år har flera studier visat på att järnhalten ökar i sjöar och vattendrag i norra Europa. Järn spelar en nyckelroll i akvatiska miljöer genom att påverka tillgängligheten av andra näringsämnen i vattnet så som kväve och fosfor, vilket kan reglera tillväxten av växtplankton. Dessutom färgar järn tillsammans med organiskt material vatten brunt. När vattnet blir brunare försämras ljusklimate

Today, the innovation arena is open to a wider range of participants than previously acknowledged. One specifically neglected group of innovators in traditional innovation studies is non-R&D and non-managerial employees, also referred to as ‘ordinary’ employees by the existing body of literature on employee-driven innovation (EDI). These employees have no formal innovation function, meaning th

The paper/presentation gives an overview of Peer-Assisted Study Schemes (SI-PASS) in Higher Education in Europe. SI-PASS is a method of improving student performance in “difficult” courses combining “how to learn” with “what to learn”. SI-PASS sessions are scheduled parallel to the regular education and are guided and facilitated by a “senior” student, the SI-PASS leader. The sessions are based on

The EU governance of food safety and GM food and feed has gone through significant changes since the BSE crisis and food scares during the 1990s. This work focuses on one particular new feature; the role of stakeholders representing the food chain: biotech associations, farmer organizations, food and feed processors, consumer organizations and environmental NGOs. These stakeholders are not merely

Energy metabolism dyshomeostasis is associated with multiple health problems. For example, abundant epidemiological data show that obesity and overweight increase the risk of cardiometabolic diseases and early mortality. Type 2 diabetes (T2D), characterized by chronically elevated blood glucose, is also associated with debilitating complications, high healthcare costs and mortality, with cardiovas

Background: As many countries seek to slow the spread of COVID-19 without reimposing national restrictions, it has become important to track the disease at a local level to identify areas in need of targeted intervention. Methods: In this prospective, observational study, we did modelling using longitudinal, self-reported data from users of the COVID Symptom Study app in England between March 24,

The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of Alzheimer's disease. However, the factors modifying the rate of tau accumulation over time in Alzheimer's disease are still largely unknown. Large-scale longi

Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. The risk allele leads to receptor overexpression in β-cells that causes increased adrenergic signaling and impaired insulin secretion. We showed that the α2A-adrenergic receptor an

MRSM12_Literature_HT25 MRSM12 Literature Literature MRSM12, Human Rights in the Global World: Agents, Indicators, and Institutions, 15 credits approved by Department of History board 2024-04-12. Subcourse I (Agents, Indicators, and Institutions) Agamben, Giorgio (1996). “Beyond Human Rights”, Radical Thought in Italy: A Potential Politics, edited by P. Virno & M. Hardt. Minneapolis: University of

https://www.ht.lu.se/media/utbildning/dokument/kurser/MRSM12/20252/MRSM12_Literature_HT25.pdf - 2025-07-29

Information and communication are increasingly being conveyed over the Internet. The forms of service and commerce that we are familiar with today will most likely be reduced in scale in the future to be replaced by new electronic solutions. For this reason, it is important that new technology be designed so that as many people as possible can utilize it. Accessibility to a range of services and i

The study makes an inventory of learning opportunities young people were offered in connection with CEI 2016, one of the annual international conferences organized by the NGO named Caretakers of the Environment International (CEI), which year 2016 took place in Aalborg in Denmark. The learning opportunities offered by this transnational learning community are discussed in relation to some essentia

IMPORTANCE The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-