Filetype
Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit g
Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern
Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod
We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer c
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this stud
Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients. Currently, it is not well understood how FTH1 contributes to an anti-tumor response. Here, we explored whether expression and cellular compartmentalization of FTH1
Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene varian
1 Stadra 2015 STADRA TEATER Redovisning säsong 2018 2 Grafisk formgivning: Fernemo Information & Grafik AB Text: Magnus Wetterholm Samtliga foton: Dragan Popović, om inget annat anges Tryckt hos: Danagård Litho november 2018 ©Ideella kulturföreningen Cirkustältet STADRA TEATER Prästgatan 26, 713 31 Nora Besöksadress: Teaterfoajén Storgatan 8, Nora 0587-31 13 05 info@stadrateater.se | www.stadratea
https://www.thm.lu.se/sites/thm.lu.se/files/stadra_2018_1205b.pdf - 2026-08-18
AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycem
Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du
With the advent of multimodality therapy, the overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort of survivors, with many years of life ahead of them, has raised the necessity for knowledge concerning the risks of adverse long-term sequelae of the life-saving treatments in order to provide optimal sc
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR) = 1.11
314490_nr1_OMSL_RRSW_2021_5.indd RESEARCH REPORTS IN SOCIAL WORK 2021:5 School of Social Work | Lund University Hur har andrahandslägenheter i Malmö kommun fördelats till hemlösa över tid? En studie av prioriteringar och exkluderingar WEDDIG RUNQUIST SOCIALHÖGSKOLAN | LUNDS UNIVERSITET LUNDS UNIVERSITET Socialhögskolan ISBN 978-91-7895-539-8 www.soch.lu.se 9 7 8 9 1 7 8 9 5 5 3 9 8 Sv an en m är k
https://www.soch.lu.se/sites/soch.lu.se/files/2021-10/Web%20RRSW%202021_5-X.pdf - 2026-08-18
Professor Kontaktinformation E-post: anna_maria [dot] jonsson [at] mgeo [dot] lu [dot] se Telefon: +46 46 222 94 10Organisation Miljö- och geovetenskapliga institutionen (MGeo) Rumsnummer: 345 Hämtställe: 16 WebbplatsAnna Maria Jönssons profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Koor
https://www.nateko.lu.se/sv/anna-maria-jonsson - 2026-08-17
Professor Kontaktinformation E-post: anna_maria [dot] jonsson [at] mgeo [dot] lu [dot] se Telefon: +46 46 222 94 10Organisation Miljö- och geovetenskapliga institutionen (MGeo) Rumsnummer: 345 Hämtställe: 16 WebbplatsAnna Maria Jönssons profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Koor
https://www.mgeo.lu.se/anna-maria-jonsson - 2026-08-17
FÖRSLAG TILL DISPOSITION 1 (15) UPPHOVSRÄTT – En översikt I denna översikt görs en genomgång av svensk upphovsrätt i allmänhet; vad och vem som skyddas av upphovsrätt, vilka rättigheter som omfattas och vilka inskränkningar som upphovsmannen får tåla, övergång av upphovsrätt och slutligen intrång i upphovsrätt. Endast den egentliga upphovsrätten, som ger skydd åt alster som kommer av ett andligt s
https://www.ub.lu.se/sites/ub.lu.se/files/upphovsraett_-_en_oeversikt.pdf - 2026-08-18
Nationella forskarskolan om åldrande och hälsa Verksamhetsberättelse 2021 CASE - Centre for Ageing and Supportive Environments Centre for Ageing and Supportive Environments Verksamhetsberättelse 2021 2 Omslagsfoto: K. Ruona. Omslagsbilden visar AnnMari Storm, medlem i CASE Brukarråd, som tillsammans med Susanne Iwarsson är i färd med att registrera data i appen för massexperimentet Bostadsförsöket
https://www.case.lu.se/sites/case.lu.se/files/2022-03/Verksamhetsbera%CC%88ttelse%20CASE%202021.pdf - 2026-08-18
Nationella forskarskolan om åldrande och hälsa Verksamhetsberättelse 2021 CASE - Centre for Ageing and Supportive Environments Centre for Ageing and Supportive Environments Verksamhetsberättelse 2021 2 Omslagsfoto: K. Ruona. Omslagsbilden visar AnnMari Storm, medlem i CASE Brukarråd, som tillsammans med Susanne Iwarsson är i färd med att registrera data i appen för massexperimentet Bostadsförsöket
https://www.case.lu.se/sites/case.lu.se/files/2022-09/Verksamhetsbera%CC%88ttelse%20CASE%202021.pdf - 2026-08-18
