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Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of Aβ, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related Aβ-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstr
Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology,
Background: The association between protein intake and prostate cancer risk remains unclear. Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid int
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery.
Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and treatment resistant tumor cells derived from mesenchymal stem cells, with minimal expression observed in non-neoplastic tissues. We have developed a humanized monocl
Biologics targeting interleukin-4 receptor subunit α (IL-4Rα) and interleukin-33 (IL-33) have demonstrated clinical efficacy in asthma, highlighting the importance of IL-4, IL-13, and IL-33 in respiratory diseases. Despite this, few studies have linked preclinical models to human diseases or evaluated disease biology in clinical trials. To address these gaps, we evaluated transcriptional, cellular
The Alzheimer’s Association and the Society of Nuclear Medicine and Molecular Imaging convened a multidisciplinary workgroup to update appropriate use criteria (AUC) for amyloid positron emission tomography (PET) and to develop AUC for tau PET. Methods: The workgroup identified key research questions that guided a systematic literature review on clinical amyloid/tau PET. Building on this review, t
Introduction To assess how national income level influences global variation in the diagnosis and management of heart failure with preserved ejection fraction (HFpEF). Methods A web-based survey on HFpEF diagnosis and treatment was distributed worldwide from May to July 2023 through email, scientific societies, and social networks. Respondents provided demographic information and details on diagno
Background Hexavalent chromium (Cr(VI)) is a carcinogen. Exposure to Cr(VI) may occur in different industrial processes such as chrome plating and stainless steel welding. The aim of this study was to assess occupational exposure to Cr(VI) in Denmark. Methods This cross-sectional study included 28 workers and 8 apprentices with potential Cr(VI) exposure and 24 within company controls, all recruite
INTRODUCTION: The Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging convened a multidisciplinary workgroup to update appropriate use criteria (AUC) for amyloid positron emission tomography (PET) and to develop AUC for tau PET. METHODS: The workgroup identified key research questions that guided a systematic literature review on clinical amyloid/tau PET. Building on
Trabecular bone score (TBS) is a grey-level textural index of bone microarchitecture derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images. TBS is a BMD-independent predictor of fracture risk. The objective of this meta-analysis was to determine whether TBS predicted fracture risk independently of FRAX probability and to examine their combined performance by adjusting the FRAX pr
The activated B cell (ABC-like) subtype of diffuse large B cell lymphoma (DLBCL) is characterized by chronic activation of signaling initiated by immunoglobulin m (IgM). By analyzing the DNA copy number profiles of 1000 DLBCL tumors, we identified gains of 18q21.2 as the most frequent genetic alteration in ABC-like DLBCL. Using integrative analysis of matched gene expression profiling data, we fou
Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWASs with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases an
The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This revie
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome
Titel: Solceller med tillhörande lagringsbatteri i flerbostadshus – Analys av lönsamhet och möjlighet att uppfylla kommande NNE-krav Författare: Frida Hansson, Christian Bakgrund: Den 1 januari 2021 träder nya, skärpta krav på byggnaders energiprestanda i kraft. Dessa krav kallas nära-nollenergikrav (NNE-krav) eftersom de tillkommer som en åtgärd för att öka antalet nära-nollenergibyggnader i SveTitle: PV-cells and storage batteries in multifamily residential buildings – Analysis of the profitability and the ability to meet the upcoming nearly zero-energy requirements Authors: Frida Hansson, Christian Jedhammar Supervisors: Karin Adalberth, Building Physics, LTH Ludvig Andersson, Teknik och hållbarhet, NCC Building SE Examiner: Åsa Wahlström, Installation Technology, LTH Problem: On 1 Jan
In 2018, Sweden passed a new law regarding rape, which is based on consent. Prior to this, a certain amount of force or threat was required, but the current legislation is based on the lack of voluntary participation. A new offense was passed, negligent rape. Thus, criminal liability for rape does not only come in question in cases of intent, but also in cases of gross negligence. The main purpose
Summary On 1 July 2013 the new state aid act entered into force. The preceding Inquiry had been instructed to consider whether special provisions were needed to enable third parties to bring actions before the Swedish courts with reference to the standstill obligation in Article 108.3 TFEU, and to leave suggestions for any legislation that might be needed in that respect. The Inquiry deemed such
Den svenska lagen på upphandlingsområdet för den klassiska sektorn, lagen om offentlig upphandling (LOU), bygger på upphandlingsdirektiv grundande på EU-fördragets bestämmelser om fri rörlighet för varor och tjänster. Rättsmedelsdirektivet, direktiv 89/665/EEG, som syftar till att säkerställa efterlevanden av upphandlingsreglerna, tillkom i början av 90-talet. Direktivet lämnade dock stort utrymmeThe Swedish law on procurement is based on Community Directives on public procurement establishing fundamental EU Treaty principles such as the principles of free movement of goods and services. The Remedies Directive (89/665/EEC), entering into force in the beginning of the 90´s, was adopted to ensure that effective and rapid remedies are available to aggrieved bidders. However, the directive let
